Two-way Bayesian hierarchical phylogenetic models: An application to the co-evolution of gp120 and gp41 during and after enfuvirtide treatment

Enfuvirtide (ENF) is a fusion inhibitor that prevents the entry of HIV virions into target cells. Studying the characteristics of viral evolution during treatment and after a treatment interruption can lend insight into the mechanisms of viral evolution and fitness. Although interruption of anti-HIV therapy often results in rapid emergence of an archived “wild-type” virus population, previous work from our group indicates that when only ENF is interrupted, viral gp41 continues to evolve forward and resistance mutations are lost due to back-mutation and remodeling of the envelope protein. To examine the co-evolution of gp120 and gp41 during ENF interruption we extend the Bayesian Hierarchical Phylogenetic model (HPM). Current HPMs enforce conditional independence across all outcomes while biologically all gene regions within a patient should return the same tree unless recombination confers an evolutionary selective advantage. A two-way-interaction HPM is proposed that provides middle ground between these two extremes and allows us to test for differences in evolutionary pressures across gene regions in multiple patients simultaneously. When the model is applied to a well-characterized cohort of HIV-infected patients interrupting ENF we find that across patients, the virus continued to evolve forward in both gene regions. Overall, the hypothesis of independence over dependence between the gene regions is supported. Models that allow for the examination of co-evolution over time will be increasingly important as more therapeutic classes are developed, each of which may impact other through novel and complex mechanisms.     

n−3 fatty acids,heart rate variability,and sudden cardiac death

Sudden cardiac death (SCD) is a major cause of mortality in Western countries. Furthermore, SCD is often the first manifestation of coronary artery disease, making it difficult to prevent. Heart rate variability (HRV), which can be determined by extended recording of the heart rate by 24-h Holter monitoring, has been shown to be one of the best predictors of the risk of SCD. There is increasing evidence from animal experiments and clinical trials in humans that n?3 fatty acids reduce the risk of SCD. We have studied the effect of n?3 fatty acids on HRV and present data clearly showing that n?3 fatty acids increase HRV. This adds further to the hypothesis that an increased intake of n?3 fatty acids may reduce the risk of SCD.     

Marine n-3 fatty acids: Basic features and background

There is some evidence from epidemiology that intake of n-3 polyunsaturated fatty acids (PUFA) from seafood may protect against coronary artery disease (CAD). This hypothesis is further supported from animal data showing a beneficial effect of n-3 PUFA on thrombosis and atherosclerosis in animals fed fish oils in most, but not all, studies. There are several mechanisms by which an increased intake of marine n-3 PUFA may protect against CAD; the most universal finding is a reduction of plasma triglycerides. It is puzzling, however, that a very low amount of n-3 PUFA, with no known beneficial biochemical effects, seems to be cardioprotective. It has therefore been of paramount interest to perform clinical trials. Such evidence and trials are discussed in later chapters, and the results have been very encouraging.     

Testing probability matching and episodic retrieval accounts of response repetition effects in task switching.

This study takes inventory of available evidence on response repetition (RR) effects in task switching, in particular the evidence for RR cost when the task switches. The review reveals that relatively few task-switching studies in which RR effects were addressed have shown statistical support for RR cost, and that almost all are affected by 1 of 2 potential artifacts, either a response bias caused by disallowing stimulus repetitions or the effect of including stimulus repetitions in data analysis. New results with these factors controlled support an episodic retrieval model in which features of the retrieved trace, including the stimulus but also the task, task cue, and response, facilitate or interfere with performance depending on whether they match or mismatch the current processing context. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Tree-to-tree variation in stearic and oleic acid content in seed fat from Allanblackia floribunda from wild stands: Potential for tree breeding

We determined whether Allanblackia floribunda, a forest tree species that is valued for the fat extracted from its seeds, could be genetically improved for fruit/seed production by sampling 17–40 fruits from each of 70 trees that were distributed among four sites in wild stands. Fat was extracted from the seeds, and stearic and oleic acid content of the fat was estimated. Highly significant (P < 0.0001) between- and within-tree variation characterised fruits and seed characters. Between-site phenotypic variation was not significant. Stearic and oleic acid percentages in seed fat ranged from 44.16% to 66.12%, and from 24.95% to 48.42% per tree sample, respectively. Moderate repeatabilities were identified in fruit characters and mean seed mass. Moderate positive relationships were found between stearic and oleic acid percentages. Seed fat profiles were not found to vary with other fruit characters. Twenty “plus trees” were selected for breeding.     

Mini‐blasting for repair work

High chloride content of the concrete had led to corrosion of reinforcement in the brackets supporting the access balconies of a block of flats in Copenhagen; also affected were parts of the balcony decks and some wall panels. Widespread replacement of the suspect components was chosen, including re‐casting of the support brackets in situ. How the old concrete of the brackets was removed by controlled local blasting is described by a member of Demex consulting engineers, who acted as explosive demolition consultants to this project.     

Exploration and exploitation in project-based organizations: Development and diffusion of knowledge at different organizational levels in construction companies

Management studies highlight the importance of an organization's capability to both exploit existing knowledge and technologies for short-term profits and also explore new knowledge and technologies to enhance long-term innovation. Although this paradox recently has received escalating interest in management research, studies dealing with project-levels and project-based organizations (PBOs) are scarce. This conceptual paper discusses how PBOs in the construction industry can manage the exploration/exploitation paradox at different organizational levels. Short-term project focus and decentralization inhibits learning from one point in time and space to another, making it easier to reap the benefits of exploitation than of exploration. Current structural and sequential separation of exploration and exploitation activities at business unit, project portfolio, and project levels do not solve the paradox, due to lack of integrating mechanisms. Hence, PBOs in the construction industry may suffer from inadequate extent of exploration, while the extent of exploitation is not reaching its potential. Cooperative procurement procedures can serve as a basis for facilitating both exploration and exploitation of knowledge and technologies in construction projects.     

Theorizing Inside Activism: Understanding Policymaking and Policy Change from Below

To further our understanding on policymaking and policy change we need to recognize the significance of individual key actors in policy and planning processes. This article theorizes on the characteristics and policy influence of inside activism in which individual public officials act strategically from inside public administration to change government policy and action in line with a civic engagement and value commitment. Based on initial empirical findings from Swedish local government, we argue that inside activism is empirically relevant but not satisfactorily covered by other key actor concepts. We theorize that inside activism is 1) dualistic: open, deliberative, consensus-seeking and tacit, tactical, power-driven; 2) influential through informal networking inside and outside of government; and 3) dynamic as it varies over time and between critical situations. Due to current trends in society and public administration (e.g. governance), we expect inside activism to be increasingly relevant and we encourage further theoretical, empirical as well as normative research and discussion on this phenomenon.     

Epoxy–graphite oxide nanocomposites: Mechanical properties

Graphite oxide (GO) produced by Hummers method was added to epoxy for strengthening purpose. Generally the E‐modulus was increased due to the GO addition; however, depending on the treatment of the GO an increase or decrease was observed for the glass transition temperature. The change in glass transition was a result of changes in the curing behavior. Addition of GO initially increased the curing speed; however, the final curing degree was lower and was dependent on the type of GO added. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133, 43591.