3D‐Printable Antimicrobial Composite Resins

3D printing is seen as a game‐changing manufacturing process in many domains, including general medicine and dentistry, but the integration of more complex functions into 3D‐printed materials remains lacking. Here, it is expanded on the repertoire of 3D‐printable materials to include antimicrobial polymer resins, which are essential for development of medical devices due to the high incidence of biomaterial‐associated infections. Monomers containing antimicrobial, positively charged quaternary ammonium groups with an appended alkyl chain are either directly copolymerized with conventional diurethanedimethacrylate/glycerol dimethacrylate (UDMA/GDMA) resin components by photocuring or prepolymerized as a linear chain for incorporation into a semi‐interpenetrating polymer network by light‐induced polymerization. For both strategies, dental 3D‐printed objects fabricated by a stereolithography process kill bacteria on contact when positively charged quaternary ammonium groups are incorporated into the photocurable UDMA/GDMA resins. Leaching of quaternary ammonium monomers copolymerized with UDMA/GDMA resins is limited and without biological consequences within 4–6 d, while biological consequences could be confined to 1 d when prepolymerized quaternary ammonium group containing chains are incorporated in a semi‐interpenetrating polymer network. Routine clinical handling and mechanical properties of the pristine polymer matrix are maintained upon incorporation of quaternary ammonium groups, qualifying the antimicrobially functionalized, 3D‐printable composite resins for clinical use.     

Influence of 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) on the localization of cathepsin B and cathepsin L in human lung tumor cells

Scatter factor (SF), also known as hepatocyte growth factor, is a potent mitogen that has been suggested to exhibit greater efficacy than vascular endothelial growth factor (VEGF) in rabbits with hindlimb ischemia. Our study examined the effects of SF on cardiovascular hemodynamics and compared the responses to VEGF. Hemodynamic parameters were monitored before and after administration of SF or VEGF in conscious, instrumented rats. Intravenous injection of SF produced a dose-related reduction in mean arterial pressure (MAP) and increase in heart rate (HR). These responses were significantly attenuated by pretreatment with N omega-nitro-L-arginine methyl ester a nitric oxide (NO) synthase inhibitor, suggesting the depressor effect of SF may be mediated by NO. SF (250 micrograms/kg) reduced stroke volume and cardiac output, but did not affect the maximal first derivation of left ventricular pressure (dP/dt), suggesting that the reduction in cardiac output is caused by decreased stroke volume that probably results from a reduction in venous return. Compared with SF, VEGF produced greater hypotensive and tachycardic responses and greater reductions in stroke volume and cardiac output, indicating that SF has fewer side effects on hemodynamics. Although both growth factors might reduce venous return, SF decreased hematocrit presumably through venodilation, whereas VEGF increased hematocrit as a result of vascular hyperpermeability.     

The ‘Cash-Point’ Service: A Verification Case Study Using STeP

STeP, the Stanford Temporal Prover, supports the computer-aided formal verification of concurrent and reactive systems based on temporal specifications [MBB99]. Automated model checking is combined with computer-aided deductive methods to allow for the verification of a broad class of systems, including parameterised (N-component) circuit designs, parameterised (N-process) programs, and programs with infinite data domains. Received February 2000 / Accepted in revised form December 2000     

Values as determinants of preferences for housing attributes

Preferences for housing attributes have beenstudied from different theoretical perspectivesand with a great variety of methodologicalapproaches. In explaining housing preferencesthe influence of both macro-level andmicro-level factors has been shownextensively. Relatively little attention hasbeen given, though, to motivational micro-levelfactors such as goals and values. In thisarticle micro-level motivational factors arestudied as determinants of stated preferencesfor housing attributes. The relationshipsbetween such motivational factors as values andgoals on the one hand and preferences forhousing attributes on the other are consideredfrom the perspective of means-end theory. Asemi-structured interviewing technique calledladdering is used for the measurement ofmeans-end chains. Some of the results of apilot project in which means-end theory wasapplied to preferences for housing attributeswill be discussed in the sequel.     

Direct TEM Observation of Phase Separation and Crystallization in Cu_(45)Zr_(45)Ag_(10)Metallic Glass

The structural evolution of Cu_(45)Zr_(45)Ag_(10) metallic glass was investigated by in situ transmission electron microscopy heating experiments. The relationship between phase separation and crystallization was elucidated. Nucleation and growth-controlled nanoscale phase separation at early stage were seen to impede nanocrystallization, while a coarser phase separation via aggregation of Ag-rich nanospheres was found to promote the precipitation of Cu-rich nanocrystals.Coupling of composition and dynamics heterogeneities was supposed to play a key role during phase separation preceding crystallization.     

Firm-level knowledge accumulation and regional dynamics

Two literatures have contributed to our insight into the determinantsof economic growth. Regional agglomeration studies emphasizethe favourable impact of geographical proximity on performance.However, the firms that constitute those agglomerations largelyremain black boxes. In contrast, studies about technologicallearning explain economic performance at the firm level withoutsystematically taking account of proximity effects. This paperproposes a possible way of bridging this gap by fusing elementsfrom both partial literatures into an integrated framework.Its value added is illustrated with an empirical example.     

Materials characterization of WNxCy, WNx and WCx films for advanced barriers

A ternary WN_xC_y system was deposited in a thermal ALD (atomic layer deposition) reactor from ASM at 300 °C in a process sequence using tungsten hexafluoride (WF₆), triethyl borane (TEB) and ammonia (NH₃) as precursors. The WC_x layers were deposited by a novel ALD process at a process temperature of 250 °C. The WN_x layers were deposited at 375 °C using bis(tert-butylimido)-bis-(dimethylamido)tungsten (^tBuN)₂(Me₂N)₂W (imido-amido) and NH₃ as precursors. WN_x grows faster on plasma enhanced chemical vapor deposition (PECVD) oxide than WC_x does on chemical oxide. WN_xC_y grows better on PECVD oxide than on thermal oxide, which is opposite of what is seen for WN_x. In the case of the ternary WN_xC_y system, the scalability towards thinner layers and galvanic corrosion behavior are disadvantages for the incorporation of the layer into Cu interconnects. ALD WC_x based barriers have a low resistivity, but galvanic corrosion in a model slurry solution of 15% peroxide (H₂O₂) is a potential problem. Higher resistivity values are determined for the binary WN_x layers. WN_x shows a constant composition and density throughout the layer.