A new method for predicting thermal conductivity of pure organic liquids and their mixtures

A new method based on Enskog's hard sphere theory for dense fluids and the principle of corresponding states is presented for predicting thermal conductivity of pure organic liquids and their mixtures. The thermal conductivities of alkanes, isoalkanes, aromatics, aldehydes, esters and ketones were calculated using this method which requires only critical properties and normal boiling point as input data. The predictions were compared with experimental data and other prediction methods over a wide range of temperatures (0.3 < T_r < 0.8) and highly satisfactory results were obtained. The method was also extended to mixtures employing simple mixing rules for calculating mixture properties.     

Parametric investigation of a double-effect solar still in comparison with a single-effect solar still

This paper reports the use of two mathematical models to compare the productivity of single-effect and double-effect solar stills under different climatic, design and operational parameters in Oman. The shallow water basin, 23° cover tilt angle, 0.1 m insulation thickness, and asphalt coating of the solar still were found to be the optimum design parameters that produced an average annual solar still yield of 4.15 kg/m²/d and 6 kg/m²/d for single and double effect solar stills, respectively. A cost analysis is carried out to shed some light on the potential of utilizing an array of single-effect solar stills or double-effect solar stills for the production of drinking water in remote areas in Oman. It has been found that the unit cost for distilled water using an array of single-effect solar stills is $74/1000 gal (16.3 $/m³) or $62.4/1000 gal (13.7 $/m³) when using a double-effect solar still. The cost saving is 15.7%.     

Higher-Order Smoothing： A Novel Semantic Smoothing Method for Text Classification

It is known that latent semantic indexing （LSI） takes advantage of implicit higher-order （or latent） structure in the association of terms and documents. Higher-order relations in LSI capture ＂latent semantics＂. These findings have inspired a novel Bayesian framework for classification named Higher-Order Naive Bayes （HONB）, which was introduced previously, that can explicitly make use of these higher-order relations. In this paper, we present a novel semantic smoothing method named Higher-Order Smoothing （HOS） for the Naive Bayes algorithm. HOS is built on a similar graph based data representation of the HONB which allows semantics in higher-order paths to be exploited. We take the concept one step further in HOS and exploit the relationships between instances of different classes. As a result, we move beyond not only instance boundaries, but also class boundaries to exploit the latent information in higher-order paths. This approach improves the parameter estimation when dealing with insufficient labeled data. Results of our extensive experiments demonstrate the value of HOS oi1 several benchmark datasets.     

Switch-peptides: design and characterization of controllable super-amyloid-forming host-guest peptides as tools for identifying anti-amyloid agents

Several amyloid-forming proteins are characterized by the presence of hydrophobic and highly amyloidogenic core sequences that play critical roles in the initiation and progression of amyloid fibril formation. Therefore targeting these sequences represents a viable strategy for identifying candidate molecules that could interfere with amyloid formation and toxicity of the parent proteins. However, the highly amyloidogenic and insoluble nature of these sequences has hampered efforts to develop high-throughput fibrillization assays. Here we describe the design and characterization of host-guest switch peptides that can be used for in vitro mechanistic and screening studies that are aimed at discovering aggregation inhibitors that target highly amyloidogenic sequences. These model systems are based on a host-guest system where the amyloidogenic sequence (guest peptide) is flanked by two beta-sheet-promoting (Leu-Ser)(n) oligomers as host sequences. Two host-guest peptides were prepared by using the hydrophobic core of Abeta comprising residues 14-24 (HQKLVFFAEDV) as the guest peptide with switch elements inserted within (peptide 1) or at the N and C termini of the guest peptide (peptide 2). Both model peptides can be triggered to undergo rapid self-assembly and amyloid formation in a highly controllable manner and their fibrillization kinetics is tuneable by manipulating solution conditions (for example, peptide concentration and pH). The fibrillization of both peptides reproduces many features of the full-length Abeta peptides and can be inhibited by known inhibitors of Abeta fibril formation. Our results suggest that this approach can be extended to other amyloid proteins and should facilitate the discovery of small-molecule aggregation inhibitors and the development of more efficacious anti-amyloid agents to treat and/or reverse the pathogenesis of neurodegenerative and systemic amyloid diseases.     

Diversity of traditional Caciocavallo cheeses produced in Italy

This paper presents the results of a survey carried out in 68 dairies in southern Italy on the manufacturing processes of traditional Italian Caciocavallo cheese varieties. Following a study of the relevant literature, the various cheesemaking processes were analysed and the implications of different cheesemaking procedures were explored. The manufacturing variations able to influence the organoleptic characteristics of Caciocavallo cheese were milk and rennet types, procedures for curd acidification and stretching, salting and ripening conditions, and smoking treatment. This survey is designed to guide producers and consumers alike with respect to the perceivable effects of manufacturing variants on cheese quality.     

Large signal design method of distributed power amplifiers applied to a 2–18-GHz GaAs chip exhibiting high power density performances

A suitable large signal design method of distributed power amplifiers, based on the optimum FET load requirement for high power operation, is proposed in this article. The gate and drain line characteristic admittances are determined, providing both the initial values and right directions for an optimum design. To validate the proposed design method, a FET amplifier demonstrator with a gate periphery of 1.2 mm has been manufactured at the Texas Instruments foundry. The MMIC distributed amplifier demonstrated an improved power density performance of 340 mW/mm over the 2–18-GHz frequency band associated with a minimum of 13% power-added efficiency and 24% drain efficiency at 1-dB compression in CW operation. © 1996 John Wiley & Sons, Inc.     

A comprehensive study of hydrogen production from ammonia borane via PdCoAg/AC nanoparticles and anodic current in alkaline medium: experimental design with response surface methodology

In this paper, the optimization of hydrogen (H₂) production by ammonia borane (NH₃BH₃) over PdCoAg/AC was investigated using the response surface methodology. Besides, the electro-oxidation of NH₃BH₃ was determined and optimized using the same method to measure its potential use in the direct ammonium boran fuel cells. Moreover, the ternary alloyed catalyst was synthesized using the chemical reduction method. The synergistic effect between Pd, Co and Ag plays an important role in enhancement of NH₃BH₃ hydrolysis. In addition, the support effect could also efficiently improve the catalytic performance. Furthermore, the effects of NH₃BH₃ concentration (0.1–50 mmol/5 mL), catalyst amount (1–30 mg) and temperature (20°C–50°C) on the rate of H₂ production and the effects of temperature (20°C–50°C), NH₃BH₃ concentration (0.05–1 mol/L) and catalyst amount (0.5–5 µL) on the electro-oxidation reaction of NH₃BH₃ were investigated using the central composite design experimental design. The implementation of the response surface methodology resulted in the formulation of four models out of which the quadratic model was adjudged to efficiently appropriate the experimental data. A further statistical analysis of the quadratic model demonstrated the significance of the model with a p-value far less than 0.05 for each model and coefficient of determination (R²) of 0.85 and 0.95 for H₂ production rate and NH₃BH₃ electrroxidation peak current, respectively.     

Design Parameter Effects on Expansion in Fluidized Beds with Inserts

The effect of some design parameters on the expansion of particles has been studied in a fluidized bed of 300 mm diameter. Four distributors were examined; three perforated plates, each perforated by holes of 0.8 mm in diameter but different hole densities at 6 mm, 9 mm and 12 mm pitch, and a porous plastic distributor 17 mm thick. Particles of different materials in the Archimedes number range from 100 to 10⁵ were fluidized. The inserts were held vertically as arrays. All experimental data for four distributors were correlated within experimental error by the equation: whereU, U_mf, U₀ are the gas velocity, velocity at minimum fluidization and real or apparent terminal velocity, while e is the bed porosity and e_mf is the porosity at the condition of minimum fluidization. P is the hole pitch of perforated plate distributor in millimeters.     

Cytoprotective Activity of Polyamines Is Associated with the Alternative Splicing of RAD51A Pre-mRNA in Normal Human CD4+ T Lymphocytes

Physiological polyamines are ubiquitous polycations with pleiotropic biochemical activities, including regulation of gene expression and cell proliferation as well as modulation of cell signaling. They can also decrease DNA damage and promote cell survival. In the present study, we demonstrated that polyamines have cytoprotective effects on normal human CD4⁺ T lymphocytes but not on cancer Jurkat or K562 cells. Pretreatment of lymphocytes with polyamines resulted in a significant reduction in cells with DNA damage induced by doxorubicin, cisplatin, or irinotecan, leading to an increase in cell survival and viability. The induction of RAD51A expression was in response to DNA damage in both cancer and normal cells. However, in normal cells, putrescin pretreatment resulted in alternative splicing of RAD51A and the switch of the predominant expression from the splice variant with the deletion of exon 4 to the full-length variant. Induction of RAD51A alternative splicing by splice-switching oligonucleotides resulted in a decrease in DNA damage and cell protection against cisplatin-induced apoptosis. The results of this study suggest that the cytoprotective activity of polyamines is associated with the alternative splicing of RAD51A pre-mRNA in normal human CD4⁺ T lymphocytes. The difference in the sensitivity of normal and cancer cells to polyamines may become the basis for the use of these compounds to protect normal lymphocytes during lymphoblastic chemotherapy.     

Synthesis and characterization of magnetic polyHIPEs with humic acid surface modified magnetic iron oxide nanoparticles

Magnetic macroporous polymer monoliths have been prepared using styrene/divinylbenzene (S/DVB) high internal phase emulsions (HIPEs) as templates. Humic acid surface modified iron oxide magnetic nanoparticles (Fe₃O₄@HA) have been used to prepare magnetic emulsion templates. The effect of magnetic particle concentration has been investigated by changing the ratio of Fe₃O₄@HA nanoparticles in the continuous phase. Highly macroporous polymers with magnetic response were obtained by the removal of the internal phase after the curing of emulsions at 80 °C. Fe₃O₄@HA particles were characterized by XRD and FTIR. The porosity, pore morphology and magnetic properties of the macroporous polymers were characterized as a function of the Fe₃O₄@HA concentration by scanning electron microscopy (SEM), Brunauer–Emmet–Teller (BET) molecular adsorption method and vibrating sample magnetometry (VSM), respectively. BET and VSM measurements demonstrated that the specific surface area and the saturation magnetization of the polymer monoliths were changed according to the Fe₃O₄@HA concentration between 8.77–35.08 m² g^?1 and 0.63–11.79 emu g^?1, respectively. Resulting magnetic monoliths were tested on the adsorption of Hg(II) and atomic absorption spectroscopy (AAS) was used to calculate the adsorption capacities. The maximum adsorption capacity of the magnetic monoliths was calculated to be 20.44 mmol g^?1 at pH 4.