基于 ResU-Net 的三维断层识别方法及应用

断层刻画了地层的边界位置,地震成像数据中反射层的不连续性可作为断层解释的主要依据。深度神经网络的强非线性性质可作为地震数据中断层不连续特征表达的有力工具,断层识别问题可视作一个像素级别的二分类问题,并使用深度学习方法对此问题进行建模求解。据此可给出一种端到端的基于深度学习网络的三维断层自动识别方法。首先利用地震子波与反射系数卷积合成多组三维地震数据,建立用于深度网络学习断层特征的样本数据,随后搭建网络进行训练,网络训练完成后应用于实际地震数据。鉴于残差模块可很好地提升网络泛化性能,所提出的将残差网络中的残差块结构引入U-Net中的方法,可用于提升通过合成数据样本训练得到的网络模型在训练数据之外,即实际地震数据上的断层识别性能。所建立网络用于断层解释时,输入为叠后三维地震数据,输出为相同维度的三维数据体,其中每一输出值代表输入三维地震数据相同位置处断层的概率。实际算例对比测试表明,此方法可对三维地震数据中的断层进行有效识别,在合成数据集上训练精度相差不大的前提下,引入残差模块的ResU-Net在实际地震数据上的断层识别泛化性能得到提升。     

Abrasion-Resistant and Enhanced Super-Slippery Flush Toilets Fabricated by a Selective Laser Sintering 3D Printing Technology

Flush toilets waste a significant amount of water every day due to the unavoidable adhesions between human waste and the toilet surfaces. Super-slippery surfaces can repel complex fluids and various viscoelastic solids, however, are easily broken by mechanical abrasions. Herein, the fabrication of an abrasion-resistant super-slippery flush toilet (ARSFT) is reported using a selective laser sintering 3D printing technology. Unlike traditional super-slippery surfaces with limited thicknesses which can be easily worn away, the powder-sintered strategy endows the ARSFT not only with a self-supporting 3D complex shape but also with a porous structure that can accommodate considerable lubricants for an abrasion-resistant super-slippery property. As a result, the as-prepared ARSFT remains clean after contacting with various liquids such as milk, yogurt, highly sticky honey, and starch gel mixed congee, demonstrating excellent repellence to complex fluids. Besides liquids, the ARSFT exhibits a high resistance to sticky synthetic feces. Notably, even after being abraded to 1,000 cycles of abrasion using sandpaper, the ARSFT maintains its record-breaking super-slippery capability. The concept of the 3D-printed object with a superior abrasion-resistant slippery ability will improve the development of super-slippery materials and further save water consumption in the human society.     

Engineered Macrophages: A Safe-by-Design Approach for the Tumor Targeting Delivery of Sub-5 nm Gold Nanoparticles

Ultrasmall nanoparticles (NPs) are a promising platform for the diagnosis and therapy of cancer, but the particles in sizes as small as several nanometers have an ability to translocate across biological barriers, which may bring unpredictable health risks. Therefore, it is essential to develop workable cell-based tools that can deliver ultrasmall NPs to the tumor in a safer manner. Here, this work uses macrophages as a shuttle to deliver sub-5 nm PEGylated gold (Au) NPs to tumors actively or passively, while reducing the accumulation of Au NPs in the brain. This work demonstrates that sub-5 nm Au NPs can be rapidly exocytosed from live macrophages, reaching 45.6% within 24 h, resulting in a labile Au NP-macrophage system that may release free Au NPs into the blood circulation in vivo. To overcome this shortcoming, two straightforward methods are used to engineer macrophages to obtain “half-dead” and “dead” macrophages. Although the efficiency of engineered macrophages for delivering sub-5 nm Au NPs to tumors is 2.2–3.8% lower than that of free Au NPs via the passive enhanced permeability and retention effect, this safe-by-design approach can dramatically reduce the accumulation of Au NPs in the brain by more than one order of magnitude. These promising approaches offer an opportunity to expand the immune cell- or stem cell-mediated delivery of ultrasmall NPs for the diagnosis and therapy of diseases in a safer way in the future.     

中立型时滞反馈扭转控制系统的稳定性分析

研究了中立型时滞动力吸振器抑制扭转系统的振动问题.针对一类强迫扭转振动系统,采用动力系统的稳定性理论分析了动力吸振器与扭转振动系统的稳定性问题,以时滞为参数,分别得到了动力吸振器与扭转振动系统的稳定区域,并研究时滞变化时动力吸振器对于主振动系统振动的吸收效果,通过与时滞动力吸振器对比,得到了更大的吸振器和减振系统时滞稳定工作区域,通过数值模拟验证了结论的正确性.     

压电谐振驱动三足机器人的平面运动

设计并实现了一类利用压电陶瓷片作动,由三条曲梁足支撑的振动驱动机器人.建立了在一条足共振驱动下机器人水平运动的动力学方程,数值计算解释了摩擦作用下的运动机理,寻找到异性摩擦对运动方向、速度的影响和压电激励频率与运动速度间的关系.通过建立圆弧曲梁控制方程求解圆弧型足面内振动的固有频率及振型,设计了三组不同频率的圆弧曲梁足参数,实验制作了机器人模型,利用压电控制三足间振动的共振切换,实现了预想的三个方向的运动以达到平面运动的效果,实验测量了机器人的运动速度与理论计算吻合得较好.     

Stability and distribution of orally administered epidermal growth factor in neonatal pigs

Stability and distribution of orally administered epidermal growth factor (EGF) were examined in newborn and 5-day-old pigs. Forty-five minutes after oral administration of iodine-125 labeled EGF, 60 and 50% of the radioactivity administered were recovered from the internal organs in newborn and 5-day-old pigs, respectively. In both age groups, over 95% of the recovered radioactivity was found in the gastrointestinal tract, of which 78-86% was found in the luminal contents with the remaining found in the gastrointestinal wall. Within the gastrointestinal tract, 65-71% of radioactivity was found in the stomach, 27-30% in the proximal and mid small intestine and 3-4% was found in the distal part of the small intestine. There were no significant differences in the overall distribution of orally administered radioactivity between two age groups. Based on liquid chromatography and trichloroacetic acid precipitation, a substantial amount of EGF recovered from the luminal contents (63-86%) and the gastrointestinal wall (42-81%) remained "intact". The receptor binding ability of the EGF recovered from the gastric contents was 96-102% comparable to the native EGF tracer. The receptor binding ability remained high (40-58%) in the proximal small intestinal lumen and it decreased to 15% in the distal small intestinal lumen in newborn pigs. In 5-day-old pigs, EGF recovered from the small intestinal contents had 5 to 24% receptor binding ability when compared with native EGF tracer. The receptor binding ability of the EGF recovered from all other organs was below 5% with an exception of the gastric wall, from which recovered EGF retained 9 to 26% receptor binding ability. These results indicate that most of orally ingested EGF remained in the gastrointestinal tract in neonatal pigs 45 min after oral ingestion, and significant amount of the ingested EGF remained biologically active. It suggests that milk-borne EGF can survive in the gastrointestinal tract and may play a role in regulating gut development in neonatal animals.     

The effects of qi-gong and acupuncture on human cerebral evoked potentials and electroencephalogram

Although a number of studies on traditional Chinese medicine, such as qi-gong (QG), acupuncture (AC), moxibustion and Chinese herbal drugs, have been reported in recent years, there are few reports on human cerebral evoked potentials (EPs), especially relating only to QG and AC. In the present study, we examined the changes in EPs and electroencephalogram (EEG) by QG, and by AC stimulation to the point called "Zusanli" on the left lower leg, with one healthy male adult. 1. With regard to the effect of QG, significant changes in EP-components originated from the cortex suggest both facilitating and inhibitory effects of QG on the cortex. However, no significant changes in EP-components originated from the subcortex and no significant changes in EEG power% suggest that QG does not affect the subcortex. 2. With regard to the effects of AC, significant changes in EP-components originated from the cortex suggest facilitating and inhibitory effects of AC stimulation on the cortex. Furthermore, it is suggested that AC stimulation has few effects on the somatosensory and the visual pathways up to the cortex, while it has complicated effects on the auditory pathway up to the cortex.     

Functional knockout of the transient outward current, long-QT syndrome, and cardiac remodeling in mice expressing a dominant-negative Kv4 alpha subunit

Amino acid changes S180A (S-->A at site 180), H197Y, Y277F, T285A, and A308S are known to shift the maximum wavelength of absorption (lambda max) of red and green visual pigments toward blue, essentially in an additive fashion. To test the generality of this "five-sites" rule, we have determined the partial amino acid sequences of red and green pigments from five mammalian orders (Artiodactyla, Carnivora, Lagomorpha, Perissodactyla, and Rodentia). The result suggests that cat (Felis catus), dog (Canis familiaris), and goat (Capra hircus) pigments all with AHYTA at the five critical sites have lambda max values of approximately 530 nm, whereas rat (Rattus norvegicus) pigment with AYYTS has a lambda max value of approximately 510 nm, which is accurately predicted by the five-sites rule. However, the observed lambda max values of the orthologous pigments of European rabbit (Oryctolagus cuniculus), white-tailed deer (Odocoileus virginianus), gray squirrel (Sciurus carolinensis), and guinea pig (Cavia procellus) are consistently more than 10 nm higher than the predicted values, suggesting the existence of additional molecular mechanisms for red and green color vision. The inferred amino acid sequences of ancestral organisms suggest that the extant mammalian red and green pigments appear to have evolved from a single ancestral green-red hybrid pigment by directed amino acid substitutions.     

Folded free-space polarization-controlled multistage interconnection network

We present a folded free-space polarization-controlled optical multistage interconnection network (MIN) based on a dilated bypass-exchange switch (DBS) design that uses compact polarization-selective diffractive optical elements (PDOE's). The folded MIN design has several advantages over that of the traditional transparent MIN, including compactness, spatial filtering of unwanted higher-order diffraction terms leading to an improved signal-to-noise ratio (SNR), and ease of alignment. We experimentally characterize a folded 2 x 2 switch, as well as a 4 x 4 and an 8 x 8 folded MIN that we have designed and fabricated. We fabricated an array of off-axis Fresnel lenslet PDOE's with a 30:1 SNR and used it to construct a 2 x 2 DBS with a measured SNR of 60:1. Using this PDOE array in a 4 x 4 MIN resulted in an increased SNR of 120:1, highlighting the filtering effect of the folded design.