Information security management system standards

This article presents ISO’s most successful information security standard ISO/IEC 27001 together with the other standards in the family of information security standards — the socalled ISO/IEC 2700x family of information security management system (ISMS) standards and guidelines. We shall take a brief look at the history and progress of these standards, where they originated from and how became the common language of organizations around the world for engaging in business securely. We shall take a tour through the different types of standard at are included in the ISMS family and how the relate and fit together and we will finally conclude with a short presentation of ISMS third party certification. The material used in this article has been derived directly from the many articles and books by Prof. Humphreys on the ISO/IEC 2700x ISMS family and they are implemented and applied in practice in business, commerce and government sectors.     

Advancements in the Development of non-BET Bromodomain Chemical Probes

The bromodomain and extra terminal (BET) family of bromodomain-containing proteins (BCPs) have been the subject of extensive research over the past decade, resulting in a plethora of high-quality chemical probes for their tandem bromodomains. In turn, these chemical probes have helped reveal the profound biological role of the BET bromodomains and their role in disease, ultimately leading to a number of molecules in active clinical development. However, the BET subfamily represents just 8/61 of the known human bromodomains, and attention has now expanded to the biological role of the remaining 53 non-BET bromodomains. Rapid growth of this research area has been accompanied by a greater understanding of the requirements for an effective bromodomain chemical probe and has led to a number of new non-BET bromodomain chemical probes being developed. Advances since December 2015 are discussed, highlighting the strengths/caveats of each molecule, and the value they add toward validating the non-BET bromodomains as tractable therapeutic targets.     

Different ways to cue a coherent memory system: A theory for episodic, semantic, and procedural tasks.

An associative theory of human memory is proposed, which serves as a counterexample to claims that disassociations between episodic, semantic, and procedural memory tasks necessitate separate memory systems. The theory is based on task analyses of matching (recognition and familiarity judgments), retrieval (cued recall with list associates, extralist associates, and part-word cues), and production (producing the first word that comes to mind). These analyses are then embedded in a distributed storage model, and it is shown how proactive interference from old memories can be largely eliminated by combining cue strengths interactively at study and test. A distinction between modality-specific and more central, modality independent, memory codes is also introduced. The model is extended to the performance of amnesic patients, and the general approach to human memory is then evaluated. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Comparison of bronchoalveolar lavage and catheter lavage to confirm ventilator-associated lower respiratory tract infection

Lower respiratory tract infection (LRTI) is a well recognised complication of artificial ventilation in intensive care units (ICU). Ideally, specimens for microbiological analysis should be obtained during bronchoscopy, but this is not always possible. Therefore, the microbiological diagnosis of lower respiratory tract infection by broncho-alveolar lavage (BAL) obtained during bronchoscopy was compared with catheter lavage (CL) with a balloon-tipped catheter. Adult patients with clinical evidence of lower respiratory tract infection in an adult ICU were randomly assigned to undergo BAL followed by CL or vice versa. Forty ml of normal saline 0.9% were instilled and then aspirated with a flexible bronchoscope to obtain BAL. A similar volume was instilled and aspirated with a 12-gauge Foley balloon-tipped catheter to obtain a CL sample. The number of inflammatory cells, epithelial cells and organisms seen by microscopy were quantified. Culture results were semi-quantified and classified as negative, positive, equivocal or contaminated. Seventy-nine paired specimens were obtained from 66 patients, including specimens from 10 patients taken on two or more occasions. Only 20% of BAL and 16% of CL had one or more epithelial cells and bacteria were seen in 26 BAL and 21 CL specimens, respectively; 35% of BAL and CL specimens were positive and there was a discrepancy in the culture result in only two cases. Staphylococcus aureus was the pathogen isolated most frequently and polymicrobial lower respiratory infection was diagnosed on 10 occasions (15%). CL fluid is as reliable as BAL in diagnosing lower respiratory tract infection in ICU. This approach does not require bronchoscopic expertise and utilises convenient laboratory techniques.     

Integration of physical and semantic information in object processing

Physiological studies report independent processing pathways for form and colour information. A more-complex picture on human subjects has previously been reported. A sequential matching task was used that was based on a physical property of an object and in which semantic relations between stimuli were manipulated. Performance was affected by semantic information when matching was based on a property of the form of an object (its orientation, shape, or size). Effects of semantic information were eliminated when matching was based on the colour of a local part of an object but were found again when subjects matched pictures on the basis of the percentage of a colour integrated across the shape boundary. The results suggest independent selection mechanisms in vision in which selection by local colour can be based on inhibition of the form-processing pathway whilst processing of the global configuration of the form of an object activates automatically the identification process.     

Recognition by action: dissociating visual and semantic routes to action in normal observers

In this article the operation of a direct visual route to action in response to objects, in addition to a semantically mediated route, is demonstrated. Four experiments were conducted in which participants made gesturing or naming responses to pictures under deadline conditions. There was a cross-over interaction in the number of visual errors relative to the number of semantic plus semantic-visual errors in the two tasks: In gesturing, compared with naming, participants made higher proportions of visual errors and lower proportions of semantic plus semantic-visual errors (Experiments 1, 3, and 4). These results suggest that naming and gesturing are dependent on separate information-processing routes from stimulus to response, with gesturing dependent on a visual route in addition to a semantic route. Partial activation of competing responses from the visual information present in objects (mediated by the visual route to action) leads to high proportions of visual errors under deadline conditions. Also, visual errors do not occur when gestures are made in response to words under a deadline (Experiment 2), which indicates that the visual route is specific to seen objects.     

A study of the drawing behavior of polyvinylidene fluoride

The drawing behavior of different molecular weight PVDF grades has been investigated over the temperature range 140–160°C, with particular reference to the production of material with enhanced mechanical and electrical properties. Lower molecular weight grades, which have been subjected to a slow-cooled rather than a quenched moulding procedure yield higher Young's moduli when drawn to a given draw ratio. X-ray diffraction measurements have demonstrated that the crystalline regions of specimens drawn to high draw ratios under these conditions consist predominantly of the piezo- and pyroelectric form I phase. The relationship between the proportion of from I phase and the final drawing stress has been shown to be unique over the temperature range investigated, irrespective of molecular weight and thermal processing history.     

Acidic volatiles from overheated polymeric materials

Previous work on the emission of smoke and fumes from overheated aircraft interior materials has included simple monitoring of acids and alkalies by means of a glass electrode in a water-bubbler. In order to put these measurements on a quantitative basis and as part of an attempt to assess the significance of acidic or alkaline fumes in terms of irritant effects, a two-way pH-stat automatic titration apparatus is now used. A small sample of material is heated at a controlled rate to 500°C in a stream of flowing air. The effluent is bubbled through water and automatically titrated for acids or alkalies. The temperatures at which these emissions occur and their amounts can be measured. Good recoveries of acids, alkalies and of both evolved consecutively have been achieved. To assess the utility of the apparatus for actual materials, the acid evolved from various types of PVC was compared. The emissions from three different nylons and from a composite cable were also investigated. Reference materials with various known additives are now being examined by the method and comparisons with irritancy measurements are being made. Ion-chromatography will be used to study the individual acid evolved.     

Computational science and scientific method

The process of constructing mathematical models is examined and a case made that the construction process is an integral part of the justification for the model. The role of heuristics in testing and modifying models is described and some consequences for scientific methodology are drawn out. Three different ways of constructing the same model are detailed to demonstrate the claims made here.     

Attention, spatial representation, and visual neglect: Simulating emergent attention and spatial memory in the selective attention for identification model (SAIM).

The selective attention for identification model (SAIM) is presented. This uses a spatial window to select visual information for recognition, binding parts to objects and generating translation-invariant recognition. The model provides a qualitative account of both normal and disordered attention. Simulations of normal attention demonstrate 2-object costs and effects of object familiarity on selection, global precedence, spatial cueing, and inhibition of return. When lesioned, SAIM demonstrated either view- or object-centered neglect or spatial extinction, depending on the type and extent of lesion. The model provides a framework to unify (a) object- and space-based theories of normal selection, (b) dissociations within the syndrome of unilateral neglect, and (c) attentional and representational accounts of neglect. (PsycINFO Database Record (c) 2010 APA, all rights reserved)