In vivo recovery with products of very high purity--assay discrepancies

To investigate the possible role of 5HT1B and/or 5HT1D receptors in controlling neurogenic inflammation, we performed a co-localization study of the mRNA for 5HT1B and 5HT1D receptors and of substance P or calcitonin gene-related peptide (CGRP) mRNA in the guinea pig trigeminal ganglion using double labelling in situ hybridization techniques. The 5HT1D receptor mRNA is abundant whereas 5HT1B receptor mRNA is scarce. The vast majority of cells containing substance P mRNA also contained 5HT1B receptor mRNA, but very few cells expressed substance P mRNA and 5HT1D receptor mRNA. Both receptor mRNAs were co-localized with CGRP mRNA. Hence, 5HT1D receptors may control the release of CGRP only, whereas 5HT1B receptors may control the release of both substance P and CGRP. The question remains whether selective 5HT1D agonists will have migraine abortive properties.     

Selecting ratings for capacitors and reactors in applicationsinvolving multiple single-tuned filters

This paper focuses on the selection of ratings for capacitors and air-core reactors used in multiple single-tuned harmonic filter configurations. Digital transient simulations of an example power system demonstrate the exceptionally high voltage and current stresses placed upon filter components in these configurations. Design guidelines for increasing the component ratings to account for the extra stresses are described. A comparison between traditional rating methods and the proposed methods are presented for the example system     

Spontaneous thrombosis of a basilar artery traumatic aneurysm in a child

Traumatic aneurysms are rare and occur most commonly in young adults; however, the relative frequency in the pediatric population is high, owing to the low prevalence of congenital saccular aneurysms in children. Traumatic aneurysms typically involve the anterior circulation, and spontaneous thrombosis is uncommon; hence, surgery is usually necessary. We present a case of a posttraumatic aneurysm in a child that occurred after a fall from a large height and that spontaneously thrombosed.     

Improvements for general-purpose s.s.i. logic packages and m.s.i./l.s.i. logic subsystems

Various specifications for general-purpose logic packages for random-logic design use have been previously proposed. Current research interests in more powerful logic design techniques, however, are suggesting newer s.s.i. integrated-circuit packages for future use, and newer and more compact subsystems within future m.s.i./l.s.i. logic packages.     

A mixed-signal approach for tuning continuous-time low-pass filters

A mixed-signal approach for tuning the bandwidth of continuous-time low-pass filters is presented. The tuning loop uses common circuit blocks (a data converter and digital filters). Simulation results are presented for a number of filters, and measured results are presented for tuning second-order and fourth-order filters.     

A second-order double-sampled delta-sigma modulator usingadditive-error switching

A second-order double-sampled delta-sigma modulator is described. It uses an additive-error switching scheme to convert capacitor mismatch into an additive out-of-band tone that can be removed by a digital filter. With a sampling rate of 5 MHz and an oversampling ratio of 256, the maximum measured signal-to-noise-and-distortion ratio (SNDR) is 86.3 dB, and the total harmonic distortion is -88.7 dB when the input is 2 dB below full scale. The modulator is fully differential, occupies 5 mm², and dissipates 13 mW     

Pulmonary cytopathology of former asbestos workers. Report of the first year

Five hundred fifty-four workers, 84% of whom are chronic cigarette smokers, have been examined during the past year with emphasis on the role of sputum cytopathology in the early detection and diagnosis of lung cancer. Of the 554, 232 (42%) have shown squamous metaplasia, 44 (8%), mild to moderate atypias, 18 (3.2%), severe atypias, and two (0.4%), squamous carcinoma. Both of the carcinomas were in x-ray negative, cytopathology-positive elderly cigarette smokers. Ferruginous bodies have been found in the sputa of 187 (33%) workers. Ferruginous bodies in the sputum do not appear to be a marker for severe atypias; rather, their presence correlates best with duration and extent of industrial exposure to asbestos.