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191.
192.
Pooyan Makvandi Melissa Kirkby Aaron R.J.Hutton Majid Shabani Cynthia K.Y.Yiu Zahra Baghbantaraghdari Rezvan Jamaledin Marco Carlotti Barbara Mazzolai Virgilio Mattoli Ryan F.Donnelly 《纳微快报(英文)》2021,(6):190-230
Transdermal microneedle(MN)patches are a promising tool used to transport a wide variety of active compounds into the skin.To serve as a substitute for common h... 相似文献
193.
This paper reviews accomplishments and planned tasks for the NRC-sponsored research program concerned with “Acoustic Emission/Flaw Relationships for Inservice Monitoring of Nuclear Reactor Pressure Boundaries”. The objective of the acoustic emission (AE) monitoring program is to develop and validate the use of AE methods for continuous surveillance of reactor pressure boundaries to detect flaw growth. Topics discussed include testing AE monitoring on reactors, refinement of an AE signal identification relationship, study of slow crack growth rate effects on AE generation, and activity to produce an ASTM standard for AE monitoring and to gain ASME code acceptance of AE monitoring. 相似文献
194.
Filipa Mota Tamas Yelland Jennie A. Hutton Jennifer Parker Anastasia Patsiarika A. W. Edith Chan Andrew O'Leary Constantina Fotinou John F. Martin Ian C. Zachary Snezana Djordjevic Paul Frankel David L. Selwood 《Chembiochem : a European journal of chemical biology》2022,23(1):e202100463
Vascular endothelial growth factors (VEGFs) regulate significant pathways in angiogenesis, myocardial and neuronal protection, metabolism, and cancer progression. The VEGF-B growth factor is involved in cell survival, anti-apoptotic and antioxidant mechanisms, through binding to VEGF receptor 1 and neuropilin-1 (NRP1). We employed surface plasmon resonance technology and X-ray crystallography to analyse the molecular basis of the interaction between VEGF-B and the b1 domain of NRP1, and developed VEGF-B C-terminus derived peptides to be used as chemical tools for studying VEGF-B - NRP1 related pathways. Peptide lipidation was used as a means to stabilise the peptides. VEGF-B-derived peptides containing a C-terminal arginine show potent binding to NRP1-b1. Peptide lipidation increased binding residence time and improved plasma stability. A crystal structure of a peptide with NRP1 demonstrated that VEGF-B peptides bind at the canonical C-terminal arginine binding site. VEGF-B C-terminus imparts higher affinity for NRP1 than the corresponding VEGF-A165 region. This tight binding may impact on the activity and selectivity of the full-length protein. The VEGF-B167 derived peptides were more effective than VEGF-A165 peptides in blocking functional phosphorylation events. Blockers of VEGF-B function have potential applications in diabetes and non-alcoholic fatty liver disease. 相似文献