The Managerial Implications of Real-Time New Product Development in Financial Services

A review of the various models of New Product Development (NPD) process shows that although different approaches have been proposed, they are in fact all variants on a linear theme: some may include feedback loops, but they all essentially advocate that certain steps precede, or are preceded by, others. An inevitable consequence on the Internet/World Wide Web (WWW or Web) is that such models are no longer applicable. Based on the lessons learned from the development of a new financial service offered via the Internet, we show how such assumptions of linearity need no longer be a constraint. In addition, innovativeness is not related to firm size. But the fact that the Web allows for the real-time development of new financial services based on on-going feedback from potential and current customers raises a new set of managerial issues that have to be tackled. The objective of this paper is to use the context of the recent launch of an innovative financial service product via the Web to explore the managerial changes that are starting to affect the banking industry.     

Modelling and solving English Peg Solitaire

Peg Solitaire is a well known puzzle, which can prove difficult despite its simple rules. Pegs are arranged on a board such that at least one ‘hole’ remains. By making draughts/checkers-like moves, pegs are gradually removed until no further moves are possible or some goal configuration is achieved. This paper considers the English variant, consisting of a board in a cross shape with 33 holes. Modelling Peg Solitaire via constraint or integer programming techniques presents a considerable challenge and is examined in detail. The merits of the resulting models are discussed and they are compared empirically. The sequential nature of the puzzle naturally conforms to a planning problem, hence we also present an experimental comparison with several leading AI planning systems. Other variants of the puzzle, such as ‘Fool's Solitaire’ and ‘Long-hop’ Solitaire are also considered.     

Evaluating Community Sex Offender Treatment Programs: A 12-Year Follow-Up of 724 Offenders.

Although some studies suggest positive effects of treatment for sexual offenders, most studies have been hampered by the unknown influence of selective attrition (e.g., volunteers and drop-outs). In the 1980s, the Correctional Service of Canada began to require weekly community treatment sessions for all sex offenders released in the Pacific Region. This policy change provided a unique opportunity for comparing an unselected cohort of treated sex offenders (n = 403) to an untreated cohort (n = 321) released in earlier years. After an average 12-year follow-up period, no differences were observed in the rates of sexual (21.1% vs 21.8%), violent (42.9% vs. 44.5%) or general (any) recidivism (56.6% vs 60.4%) for treated and untreated groups, respectively. The outcome remained comparable after controlling for length of follow- up, year of release, age, and seven static risk factors coded from official criminal history records. Retrospective ratings of the treatment quality also showed no relationship to observed recidivism rates. The static risk factors coded in the current study accounted for considerable variance in recidivism and could easily be used to improve statistical controls in future evaluations. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Velocity Distribution in the Roughness Layer of Rough-Bed Flows

Several models for the vertical distribution of the double-averaged (in time and in the plane parallel to the mean bed) longitudinal velocity in the flow region between roughness troughs and roughness tops are suggested. We found that the same model for velocity distribution may be applicable to a range of flow conditions and roughness types, which share some common features. The suggested models for velocity distribution in the near-bed region are: (1) Constant velocity; (2) exponential velocity distribution; and (3) linear velocity distribution. The measured velocity distributions may be approximated by a single model or by a combination of models depending on roughness geometry and flow conditions. The validity of these models for velocity distribution is supported by laboratory data.     

3D television: Developing a multi‐modal multi‐viewer TV system of the future

Abstract— Under the European Union funded Advanced Three‐dimensional Television System Technologies (ATTEST) project, De Montfort University (DMU) is developing a 3D display system targeted specifically at domestic television applications. This system uses a modified transmissive LCD panel together with novel backlighting and optics to project multiple viewing regions, or exit pupils, into the viewing space. These exit pupils are located in space using a head tracker. The display accommodates multiple viewers simultaneously and imposes no physical constraints, such as special eyewear. Viewers may move freely over a “typical” room‐sized area. The design of the backlighting facilitates many other display regimes beyond the “standard” 3DTV mode in which each viewer sees the same image pair.     

Propagation of Data Error and Parametric Sensitivity in Computable General Equilibrium Models

While computable general equilibrium (CGE) models are a well-established tool in economic analyses, it is often difficult to disentangle the effects of policies of interest from that of the assumptions made regarding the underlying calibration data and model parameters. To characterize the behavior of a CGE model of carbon output with respect to two of these assumptions, we perform a large-scale Monte Carlo experiment to examine its sensitivity to base year calibration data and elasticity of substitution parameters in the absence of a policy change. By examining a variety of output variables at different levels of economic and geographic aggregation, we assess how these forms of uncertainty impact the conclusions that can be drawn from the model simulations. We find greater sensitivity to uncertainty in the elasticity of substitution parameters than to uncertainty in the base-year data as the projection period increases. While many model simulations were conducted to generate large output samples, we find that few are required to capture the mean model response of the variables tested. However, characterizing standard errors and empirical probability distribution functions is not possible without a large number of simulations.     

A multicomputer garbage collector for a single-assignment language

An asynchronous garbage collector for a message-passing multiprocessor (multicomputer) is described. This combines Weighted Reference Counting (WRC) interprocessor collection and tracing intraprocessor collection to permit individual processors to reclaim local storage independently. A novel feature is the integration of Weighted Reference Counting collection and the communication algorithms required to support a global address space in a single assignment language. This significantly reduces communication overhead and space requirements attributable to garbage collection. In addition, techniques are described that avoid the creation of cyclic structures that cannot be reclaimed using WRC. Experimental studies performed in a concurrent logic programming system that incorporates the collector confirm its efficiency and the benefits of integrating garbage collector and language implementation.     

Nanoparticle-functionalized porous polymer monolith detection elements for surface-enhanced Raman scattering

The use of porous polymer monoliths functionalized with silver nanoparticles is introduced in this work for high-sensitivity surface-enhanced Raman scattering (SERS) detection. Preparation of the SERS detection elements is a simple process comprising the synthesis of a discrete polymer monolith section within a silica capillary, followed by physically trapping silver nanoparticle aggregates within the monolith matrix. A SERS detection limit of 220 fmol for Rhodamine 6G is demonstrated, with excellent signal stability over a 24 h period. The capability of the SERS-active monolith for label-free detection of biomolecules was demonstrated by measurements of bradykinin and cytochrome c. The SERS-active monoliths can be readily integrated into miniaturized micrototal-analysis systems for online and label-free detection for a variety of biosensing, bioanalytical, and biomedical applications.     

MicroRNA-Based Diagnosis and Therapy

MicroRNAs (miRNAs) are a group of endogenous non-coding RNAs that regulate gene expression. Alteration in miRNA expression results in changes in the profile of genes involving a range of biological processes, contributing to numerous human disorders. With high stability in human fluids, miRNAs in the circulation are considered as promising biomarkers for diagnosis, as well as prognosis of disease. In addition, the translation of miRNA-based therapy from a research setting to clinical application has huge potential. The aim of the current review is to: (i) discuss how miRNAs traffic intracellularly and extracellularly; (ii) emphasize the role of circulating miRNAs as attractive potential biomarkers for diagnosis and prognosis; (iii) describe how circulating microRNA can be measured, emphasizing technical problems that may influence their relative levels; (iv) highlight some of the circulating miRNA panels available for clinical use; (v) discuss how miRNAs could be utilized as novel therapeutics, and finally (v) update those miRNA-based therapeutics clinical trials that could potentially lead to a breakthrough in the treatment of different human pathologies.     

ICOSL Stimulation by ICOS-Fc Accelerates Cutaneous Wound Healing In Vivo

Background: ICOS and its ligand ICOSL are immune receptors whose interaction triggers bidirectional signals that modulate the immune response and tissue repair. Aim: The aim of this study was to assess the in vivo effects of ICOSL triggering by ICOS-Fc, a recombinant soluble form of ICOS, on skin wound healing. Methods: The effect of human ICOS-Fc on wound healing was assessed, in vitro, and, in vivo, by skin wound healing assay using ICOS^−/− and ICOSL^−/− knockout (KO) mice and NOD-SCID-IL2R null (NSG) mice. Results: We show that, in wild type mice, treatment with ICOS-Fc improves wound healing, promotes angiogenesis, preceded by upregulation of IL-6 and VEGF expression; increases the number of fibroblasts and T cells, whereas it reduces that of neutrophils; and increases the number of M2 vs. M1 macrophages. Fittingly, ICOS-Fc enhanced M2 macrophage migration, while it hampered that of M1 macrophages. ICOS^−/− and ICOSL^−/− KO, and NSG mice showed delayed wound healing, and treatment with ICOS-Fc improved wound closure in ICOS^−/− and NSG mice. Conclusion: These data show that the ICOS/ICOSL network cooperates in tissue repair, and that triggering of ICOSL by ICOS-Fc improves cutaneous wound healing by increasing angiogenesis and recruitment of reparative macrophages.