Randomized Trial of Cognitive-Behavioral Therapy for Chronic Posttraumatic Stress Disorder in Adult Female Survivors of Childhood Sexual Abuse.

The authors conducted a randomized clinical trial of individual psychotherapy for women with posttraumatic stress disorder (PTSD) related to childhood sexual abuse (n = 74), comparing cognitive-behavioral therapy (CBT) with a problem-solving therapy (present-centered therapy; PCT) and to a wait-list (WL). The authors hypothesized that CBT would be more effective than PCT and WL in decreasing PTSD and related symptoms. CBT participants were significantly more likely than PCT participants to no longer meet criteria for a PTSD diagnosis at follow-up assessments. CBT and PCT were superior to WL in decreasing PTSD symptoms and secondary measures. CBT had a significantly greater dropout rate than PCT and WL. Both CBT and PCT were associated with sustained symptom reduction in this sample. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

DNA sensing by amplifying the number of near-infrared emitting, oligonucleotide-encapsulated silver clusters

A bifunctional oligonucleotide integrates in situ synthesis of a fluorogenic silver cluster with recognition of a target DNA sequence. With the template C(3)AC(3)AC(3)GC(3)A, a complex forms with 10 silver atoms that possesses electronic transitions in the near-infrared and that is detected at nanomolar concentrations using diode laser excitation. Pendant to this cluster encoding region, the recognition component binds a target DNA strand through hybridization, and decoupling of these two regions of the composite sensor renders a modular sensor for specific oligonucleotides. A target is detected using a quencher strand that bridges the cluster template and recognition components and disturbs cluster binding, as indicated by static quenching. Competitive displacement of the quencher by the target strand restores the favored cluster environment, and our key finding is that this exchange enhances emission through a proportional increase in the number of emissive clusters. DNA detection is also accomplished in serum-containing buffers by taking advantage of the high brightness of this fluorophore and the inherently low endogenous background in the near-infrared spectral region. Cluster stability in this biological environment is enhanced by supplementing the solutions with Ag(+).     

Chemical-induced pH-mediated molecular switch

The transmembrane protein α-hemolysin pore has been used to develop ultrasensitive biosensors, study biomolecular folding and unfolding, investigate covalent and noncovalent bonding interactions, and probe enzyme kinetics. Here, we report that, by addition of ionic liquid tetrakis(hydroxymethyl)phosphonium chloride solution to the α-hemolysin pore, the α-hemolysin channel can be controlled open or closed by adjusting the pH of the solution. This approach can be employed to develop a novel molecular switch to regulate molecular transport and should find potential applications as a "smart" drug delivery method.     

MWCNT reinforced Polyamide-6,6 films: preparation,characterization and properties

Composite films of Polyamide-6,6 (PA66) and multi-walled carbon nanotubes (MWCNTs) were prepared by a combination of solution casting followed by compression molding techniques. Both unfunctionalized (u-MWCNTs) and functionalized nanotubes (f-MWCNTs) were used in this study. The functionalization involved direct solvent-free amination of MWCNTs with hexamethylenediamine. Thermogravimetric analysis was used to observe the changes in the nanotubes upon functionalization and morphological features of the resulting composite films were studied using scanning electron microscopy, transmission electron microscopy, and atomic force microscopy. The crystallinity changes by incorporation of the u-MWCNTs and f-MWCNTs in the PA66 matrix were studied by wide angle X-ray scattering and differential scanning calorimetry. The f-MWCNT/PA66 film showed an improvement of ∼43% in maximum tensile stress (MTS) and ∼32% in Young’s modulus over pristine PA66 film, while at a similar loading of 0.5 wt%, the f-MWCNT/PA66 film showed ∼15% increase in MTS and ∼16% increase in modulus over the u-MWCNT/PA66 film. Dynamic mechanical analysis indicated significant difference in the small-strain mechanical properties between the MWCNT-filled and unfilled PA66 at the very low MWNT loadings that were tested and supported the tensile results. The water absorption trend of the composite films showed dramatic improvement over the neat film.     

Pricing decisions for three-echelon supply chain with advertising and quality effort-dependent fuzzy demand

Simultaneous influence of market power structure, advertising and quality efforts on the optimal pricing decisions and performance of a multi-echelon supply chain under uncertainty have received scant attention in the literature. We focus on this gap by examining a serial decentralised three-echelon supply chain consisting of a supplier, a manufacturer and a retailer. The uncertainty associated with customer demand, marginal production costs and effort costs is expressed as linguistic or fuzzy variables. We analyse centralised supply chain to obtain all benchmark parameters. We investigate four decentralised supply chain cases through fuzzy game theoretic approach. We compare among three Stackelberg games with various supply chain leaderships and a vertical Nash. Our key findings are as follows. First, the manufacturer puts least quality effort while retailer puts least advertising effort when they act as Stackelberg leader in a three-echelon supply chain. Second, supplier's per unit price is governed by the channel leadership in three-echelon supply chain while retail prices are less affected by the leadership. We investigate the impact of fuzzy degree of quality and advertising sensitivity on optimal profit distribution among agents. We present numerical analysis to illustrate the importance of the derived theoretical results and discuss additional managerial insights.     

Effect of gravity on visco-elastic surface waves in solids involving time rate of strain and stress of first order

The aim of the present paper is to study the effect of gravity on visco-elastic surface waves in solids. The wave velocity equations are deduced from Biot’s theory of initial stress on the assumption that gravity creates a type of initial stress — hydrostatic in nature. Resulting equations are used to investigate surface waves of the Rayleigh, Love and Stoneley types. Results are in good agreement with corresponding classical results when gravity and viscosity are neglected.     

Design of efficient lightweight strategies to combat DoS attack in delay tolerant network routing

Delay tolerant networks (DTNs) are characterized by delay and intermittent connectivity. Satisfactory network functioning in a DTN relies heavily on co-ordination among participating nodes. However, in practice, such co-ordination cannot be taken for granted due to possible misbehaviour by relay nodes. Routing in a DTN is, therefore, vulnerable to various attacks, which adversely affect network performance. Several strategies have been proposed in the literature to alleviate such vulnerabilities—they vary widely in terms of throughput, detection time, overhead etc. One key challenge is to arrive at a tradeoff between detection time and overhead. We observe that the existing table-based reactive strategies to combat Denial-of-service (DoS) attacks in DTN suffer from two major drawbacks: high overhead and slow detection. In this paper, we propose three secure, light-weight and time-efficient routing algorithms for detecting DoS attacks (Blackhole and Grey-hole attacks) in the Spray & Focus routing protocol. The proposed algorithms are based on use of a small fraction of privileged (trusted) nodes. The first strategy, called TN, outperforms the existing table-based strategy with 20–30 % lesser detection time, 20–25 % higher malicious node detection and negligible overhead. The other two strategies, CTN_MI and CTN_RF explore the novel idea that trusted nodes are able to utilize each others’ information/experience using their long range connectivity as and when available. Simulations performed using an enhanced ONE simulator reveals that investing in enabling connectivity among trusted nodes (as in CTN_RF) can have significant performance benefits.     

Effect of N-Vinyl-2-Pyrrolidone (NVP), a Bromodomain-Binding Small Chemical,on Osteoblast and Osteoclast Differentiation and Its Potential Application for Bone Regeneration

The human skeleton is a dynamic and remarkably organized organ system that provides mechanical support and performs a variety of additional functions. Bone tissue undergoes constant remodeling; an essential process to adapt architecture/resistance to growth and mechanical needs, but also to repair fractures and micro-damages. Despite bone’s ability to heal spontaneously, certain situations require an additional stimulation of bone regeneration, such as non-union fractures or after tumor resection. Among the growth factors used to increase bone regeneration, bone morphogenetic protein-2 (BMP2) is certainly the best described and studied. If clinically used in high quantities, BMP2 is associated with various adverse events, including fibrosis, overshooting bone formation, induction of inflammation and swelling. In previous studies, we have shown that it was possible to reduce BMP2 doses significantly, by increasing the response and sensitivity to it with small molecules called “BMP2 enhancers”. In the present study, we investigated the effect of N-Vinyl-2-pyrrolidone (NVP) on osteoblast and osteoclast differentiation in vitro and guided bone regeneration in vivo. We showed that NVP increases BMP2-induced osteoblast differentiation and decreases RANKL-induced osteoclast differentiation in a dose-dependent manner. Moreover, in a rabbit calvarial defect model, the histomorphometric analysis revealed that bony bridging and bony regenerated area achieved with NVP-loaded poly (lactic-co-glycolic acid (PLGA) membranes were significantly higher compared to unloaded membranes. Taken together, our results suggest that NVP sensitizes BMP2-dependent pathways, enhances BMP2 effect, and inhibits osteoclast differentiation. Thus, NVP could prove useful as “osteopromotive substance” in situations where a high rate of bone regeneration is required, and in the management of bone diseases associated with excessive bone resorption, like osteoporosis.     

Performance analysis of a packet assembly function

A general packet assembly function in which the bundle is completed whenever any one of a number of conditions is satisfied is analyzed. These conditions subsume those most commonly found in practice. The analysis yields the distribution of bundle size. In several useful cases, closed form expressions for the mean bundle size is obtained