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91.
Ariane Borges Chi Nguyen Madison Letendre Iryna Onasenko Rene Kandler Ngoc K. Nguyen Jue Chen Tamara Allakhverdova Emily Atkinson Bella DiChiara Caroline Wang Noa Petler Henna Patel Dr. Dhaval Nanavati Dr. Samir Das Prof. Dr. Arundhati Nag 《Chembiochem : a European journal of chemical biology》2023,24(4):e202200590
While most FDA-approved peptide drugs are cyclic, the robust cyclization chemistry of peptides and the deconvolution of cyclic peptide sequences by using tandem mass spectrometry render cyclic peptide drug discovery difficult. Here we present the successful design of cyclic peptides on solid phase that addresses both of these problems. We demonstrate that this peptide cyclization method using dichloro-s-tetrazine on solid phase allows successful cyclization of a panel of random peptide sequences with various charges and hydrophobicities. The cyclic peptides can be linearized and cleaved from the solid phase by simple UV light irradiation, and we demonstrate that accurate sequence information can be obtained for the UV-cleaved linearized peptides by using tandem mass spectrometry. The tetrazine linker used in the cyclic peptides can further be explored for inverse electron-demand Diels-Alder (IEDDA) reactions for screening or bioconjugation applications in the future. 相似文献
92.
Kostyantyn Grytsenko Yurii Kolomzarov Peter Lytvyn Olga Kondratenko Mykola Sopinskyy Iryna Lebedyeva Agata Niemczyk Jolanta Baranovska Dariusz Moszyński Claus Villringer Sigurd Schrader 《大分子材料与工程》2023,308(6):2200617
Thin polytetrafluoroethylene (PTFE) films are produced by deposition from a gas phase by two methods: electron-enhanced vacuum deposition (EVD) and EVD + low-temperature plasma (LTP). Structure, morphology, and composition of the films are studied by IR spectroscopy, atomic force microscopy, and X-ray photoelectron spectroscopy. They are close to the structure of bulk PTFE. The roughness of the films’ surface is changed with gas pressure and LTP power variations. Films are transparent from UV to near-infrared regions. Refractive and extinction indices and their anisotropy are measured by spectral ellipsometry. They are tuned by variations of deposition conditions. Hardness and Young modulus of the films are increased if EVD + low power LTP is used for film deposition. Use of EVD + LTP also increases thermal stability of the films. Contact angle of the films corresponds to the bulk PTFE. The PTFE molecules oriented are preferentially in perpendicular direction to the substrate surface. 相似文献