Multishot echoplanar MR imaging of the female pelvis: comparison with fast spin-echo MR imaging in an initial clinical trial

OBJECTIVE: The purpose of this study was to apply multishot echoplanar MR imaging (EPI) to the female pelvis and compare image quality with that of fast spin-echo MR imaging. SUBJECTS AND METHODS: Twenty-one patients with suspected pelvic disease and five healthy female volunteers were prospectively examined. MR imaging was obtained using an EPI-capable 1.0-T imager and a pelvic phased-array coil. Axial EPI and fast Spin-echo sequences were obtained at identical image locations in each patient and volunteer. Spin-echo EPI images were obtained using a multishot number of 16. Acquisition time for each EPI sequence was 2 min 10 sec. Fat-suppressed T2-weighted fast spin-echo images were obtained in 2 min 12 sec. Paired EPI and fast spin-echo MR images were independently evaluated by three reviewers. RESULTS: Delineation of the perivaginal and parametrial venous plexus on EPI was rated superior to the fast spin-echo images in 62 (77%) of 81 cases. On EPI, uterine zone anatomy and ovary visualization were judged to be inferior in 44 (56%) of 78 cases and in 18 (33%) of 54 cases, respectively. For delineation of uterine abnormalities, including leiomyoma and adenomyosis, both sequences performed almost equally well. However, ovarian cystic lesions were revealed more precisely by the fast spin-echo sequence. An overall fat-suppression effect was seen on EPI images in 62 (77%) of 81 cases. CONCLUSION: Multishot EPI cannot replace fast spin-echo sequences for imaging the female pelvis; however, because EPI has a potent fat-suppression effect and heavily T2-weighted contrast, EPI sequences can be a valuable adjunct to routine examination.     

Efficient emulation of single-hop radio network with collision detection on multi-hop radio network with no collision detection

Summary This paper presents an efficient randomized emulation ofsingle-hop radio networkwith collision detection onmulti-hop radio networkwithout collision detection. Each step of the single-hop network is emulated by rounds of the multi-hop network and succeeds with probability 1–. (n is the number of processors,D the diameter and the maximum degree). It is shown how to emulate any polynomial algorithm such that the probability of failure remains . A consequence of the emulation is an efficient randomized algorithm for choosing a leader in a multi-hop network. Reuven Bar-Yehuda was born in Iran, on July 17th 1951. Received B.A., M.Sc., and D.Sc. in Computer Science from the Technion — Israel Institute of Technology, Haifa, Israel, in 1978, 1980, and 1983, respectively. He is currently a Senior Lecturer of Computer Science at the Technion. From 1984 to 1986, he was a visiting assistant professor in the Computer Science Dept. at the Duke Univesity His research interests include computational geometry, VLSI, graph algorithms and distributed algorithms. Oded Goldreich was born in Tel-Aviv, Israel, on February 4th 1957. Received B.A., M.Sc., and D.Sc. in Computer Science from the Technion — Israel Institute of Technology, Haifa, Israel, in 1980, 1982, and 1983, respectively. He is currently an Associate Professor of Computer Science at the Technion. From 1983 to 1986, he was a postdoctoral fellow at MIT's Laboratory for Computer Science. His research interests include cryptography and related areas, relation between randomness and algorithms, and distributed computation. Alon Itai was born in Scotland, on December 12th 1946. Received B.Sc. in Mathematics from the Hebrew University in Jerusalem in 1969. M.Sc., and Ph.D. in Computer Science from the Weizmann Institute of Science, Rehovot, Israel in 1971 and 1976. He is currently an Associate Professor of Computer Science at the Technion. His research interests include randomized and distributed algorithms, computational learning theory and performance evaluation.The second author was partially supported by grant No. 86-00301 from the United States—Israel Bi-national Science Foundation BSF), Jerusalem, Israel.     

Birds of a Feather Tweet Together: Integrating Network and Content Analyses to Examine Cross‐Ideology Exposure on Twitter

This study integrates network and content analyses to examine exposure to cross‐ideological political views on Twitter. We mapped the Twitter networks of 10 controversial political topics, discovered clusters – subgroups of highly self‐connected users – and coded messages and links in them for political orientation. We found that Twitter users are unlikely to be exposed to cross‐ideological content from the clusters of users they followed, as these were usually politically homogeneous. Links pointed at grassroots web pages (e.g.: blogs) more frequently than traditional media websites. Liberal messages, however, were more likely to link to traditional media. Last, we found that more specific topics of controversy had both conservative and liberal clusters, while in broader topics, dominant clusters reflected conservative sentiment.     

The Proto-Ribosome: An Ancient Nano-machine for Peptide Bond Formation

The ribosome is a ribozyme whose active site, the peptidyl transferase center (PTC), is situated within a highly conserved universal symmetrical region that connects all ribosomal functional centers involved in amino acid polymerization. The linkage between this elaborate architecture and A-site tRNA position revealed that the A- to P-site passage of the tRNA 3′ terminus during protein synthesis is performed by a rotary motion, synchronized with the overall tRNA/mRNA sideways movement, and guided by the PTC. This rotary motion leads to suitable stereochemistry for peptide bond formation as well as for substrate-mediated catalysis. Analysis of the substrate binding modes to ribosomes led to the hypothesis that the ancient ribosome produced single peptide bonds and non-coded chains, potentially in a similar manner to the modern PTC. Later in evolution, a mechanism, enabling some type of decoding genetic control triggered the emergence of the small ribosomal subunit or part of it. This seems to be the result of the appearance of reaction products that could have evolved after polypeptides capable of enzymatic function were generated sporadically, while an ancient stable RNA fold was converted into an old version of a tRNA molecule. Since in the contemporary ribosome, the symmetry relates only to the backbone fold and nucleotide orientations but not nucleotide sequences, it emphasizes the superiority of functional requirement over sequence conservation, and indicates that the PTC may have evolved by gene fusion or gene duplication.     

Insights into early hydration of Portland limestone cement from infrared spectroscopy and isothermal calorimetry

Isothermal calorimetry and diffuse reflectance infrared DR-FTIR spectroscopy are combined to correlate evolutions of spectroscopic signatures with rates of chemical reactions as reflected in the rate of heat emitted during the first 38 h of cement hydration. Portland limestone cement mortar is employed and the analysis is repeated for two different mixing procedures. Intensive blender mixing with quartz sand is found to cause activation of the cement resulting in a faster hydration process. At early stages of hydration, two types of C-S-H are formed. The spectral intensity of the earlier C-S-H is found to saturate, while that of the later form continues to acquire intensity throughout the 38 h of the experiment. Evidences are presented which support the interpretation that the two forms differ mainly in morphology and water content. Simultaneously with the saturation of the early C-S-H, a transient species is observed with DR-FTIR. This species correlates with the observed thermogram fine-structure.     

Implementing Power‐to‐Gas to provide green hydrogen to a bitumen upgrader

Hydrogen is an important commodity in the processing of intermediate bitumen products into a finished petroleum product and for upgrading bitumen into synthetic crude. With the continued extraction of bitumen‐rich material from Alberta's oil sands project, there is an opportunity to reduce the greenhouse gas emissions of upgrading and refining operations by using electrolytically produced hydrogen in place of hydrogen produced by steam methane reformation. Recently, a bitumen upgrading facility had been proposed for the city of Sarnia, Ontario because of its pre‐existing petroleum processing infrastructure. Using the Ontario electrical system, which has a lower emissions factor than Alberta, the use of electrolytic hydrogen could result in a significant reduction of greenhouse gasses. In this paper, the objective is to determine an optimal system configuration for reducing greenhouse gas emissions while maintaining a low system cost. The analysis is performed with General Algebraic Modelling System tool, a mixed‐integer linear optimization in addition to a simple model in Visual Basic. For each case, an economic and environmental analysis is performed including the use of cap‐and‐trade values for the price of carbon emissions, which are applied to determine the overall economic impact of the emissions reductions. Copyright © 2016 John Wiley & Sons, Ltd.     

Atomic Layer Deposition for Membranes,Metamaterials, and Mechanisms

Bending and folding techniques such as origami and kirigami enable the scale‐invariant design of 3D structures, metamaterials, and robots from 2D starting materials. These design principles are especially valuable for small systems because most micro‐ and nanofabrication involves lithographic patterning of planar materials. Ultrathin films of inorganic materials serve as an ideal substrate for the fabrication of flexible microsystems because they possess high intrinsic strength, are not susceptible to plasticity, and are easily integrated into microfabrication processes. Here, atomic layer deposition (ALD) is employed to synthesize films down to 2 nm thickness to create membranes, metamaterials, and machines with micrometer‐scale dimensions. Two materials are studied as model systems: ultrathin SiO₂ and Pt. In this thickness limit, ALD films of these materials behave elastically and can be fabricated with fJ‐scale bending stiffnesses. Further, ALD membranes are utilized to design micrometer‐scale mechanical metamaterials and magnetically actuated 3D devices. These results establish thin ALD films as a scalable basis for micrometer‐scale actuators and robotics.     

A two-state electronic antigen and an antibody selected to discriminate between these states

Inspired by biology where pathways are triggered and suppressed by specific binding of two molecules, we realize a functional interface between electronics and biology by replacing one of the pair molecules with a two-state "electronic antigen" device comprising a hydroquinone monolayer assembled on gold, and choosing for the pair molecule an antibody that discriminates between the two electrically selected redox states of the monolayer. Application of an oxidative +0.6 V pulse to the antigen switches it to its benzoquinone state where antibodies bind the layer. A subsequent -0.6 V pulse reduces the monolayer back to the unbinding hydroquinone state, releases the specifically bound antibody molecules, and prevents further binding.