The HLD Study of Surfactant Partitioning for Oilfield Corrosion Inhibitors

The partitioning of corrosion inhibitor (CI) products is a measure of their potential to protect oilfield pipelines. In this paper the hydrophilic–lipophilic deviation (HLD) model is first used to quantify their partitioning in terms of the characteristic curvature (C _c,act) of a series of anionic (alkoxylated phosphate esters) and cationic (alkoxylated amines, aromatic amines, imidazoline acetates and quaternary amines) actives. This parameter is expressed over a range of pHs within which pipeline corrosion occurs. The HLD model is next used to predict the partitioning of each active from water into toluene at increased salinities. Linear mixing rules are lastly used to predict the characteristic curvature of Product A (C _c,mix) as a function of the C _c,act of a subset of actives.     

Copper(I) Bromide‐Dimethyl Sulfide‐Catalyzed Direct Sulfanylation of 4‐Hydroxycoumarins and 4‐Hydroxyquinolinones with Arylsulfonylhydrazides and Selective Fluorescence Switch‐ On Sensing of Cadmium(II) Ion in Water

An efficient protocol for the direct sulfanylation of various 4‐hydroxycoumarins and 4‐hydroxyquinolinones in good yield with arylsulfonylhydrazides as sulfanylating agents was developed via copper(I) bromide⋅dimethyl sulfide‐catalyzed S–O, S–N bond cleavage and C–S cross‐coupling reactions. A highly selective fluorescence turning‐on sensing of cadmium(II) ions in water using the synthesized 3‐sulfanyl‐4‐hydroxycoumarin derivative was also investigated.

     

On the association between poly(vinyl alcohol) and sodium dodecyl sulfate and its effect on liquid–liquid interfacial tension: A mathematical model

Association between poly(vinyl alcohol-co-vinyl acetate) copolymer (PVA) and sodium dodecyl sulfate (SDS) was studied experimentally and theoretically. It was found that, for the ethyl acetate-aqueous phase interface in which PVA was previously adsorbed, the interfacial tension (γ) increases abruptly to a maximum and then exhibits a relatively mild decay with the addition of SDS to the aqueous phase. The theoretical results indicate that vinyl acetate (VAc) segments determine γ. However, for relatively low concentrations of SDS (C_SDS), this latter plays a major role because through its association with the VAc segments it modulates the extent to which PVA is adsorbed at the interface, indirectly determining the value of γ. As C_SDS approaches to the CMC value for SDS, its influence on γ decreases because SDS tends to self-assembly rather than associates with VAc. These model predictions are consistent with experimental findings reported in the literature.     

Linear Aliphatic Dialkynes as Alternative Linkers for Double‐Click Stapling of p53‐Derived Peptides

We investigated linear aliphatic dialkynes as a new structural class of i,i+7 linkers for the double‐click stapling of p53‐based peptides. The optimal combination of azido amino acids and dialkynyl linker length for MDM2 binding was determined. In a direct comparison between aliphatic and aromatic staple scaffolds, the aliphatic staples resulted in superior binding to MDM2 in vitro and superior p53‐activating capability in cells when using a diazidopeptide derived from phage display. This work demonstrates that the nature of the staple scaffold is an important factor that can affect peptide bioactivity in cells.     

Phenoxybenzamine Is Neuroprotective in a Rat Model of Severe Traumatic Brain Injury

Phenoxybenzamine (PBZ) is an FDA approved α-1 adrenergic receptor antagonist that is currently used to treat symptoms of pheochromocytoma. However, it has not been studied as a neuroprotective agent for traumatic brain injury (TBI). While screening neuroprotective candidates, we found that phenoxybenzamine reduced neuronal death in rat hippocampal slice cultures following exposure to oxygen glucose deprivation (OGD). Using this system, we found that phenoxybenzamine reduced neuronal death over a broad dose range (0.1 μM–1 mM) and provided efficacy when delivered up to 16 h post-OGD. We further tested phenoxybenzamine in the rat lateral fluid percussion model of TBI. When administered 8 h after TBI, phenoxybenzamine improved neurological severity scoring and foot fault assessments. At 25 days post injury, phenoxybenzamine treated TBI animals also showed a significant improvement in both learning and memory compared to saline treated controls. We further examined gene expression changes within the cortex following TBI. At 32 h post-TBI phenoxybenzamine treated animals had significantly lower expression of pro-inflammatory signaling proteins CCL2, IL1β, and MyD88, suggesting that phenoxybenzamine may exert a neuroprotective effect by reducing neuroinflammation after TBI. These data suggest that phenonxybenzamine may have application in the treatment of TBI.     

Analysis of UK river restoration using broad‐scale data sets

This paper uses data from the UK River Restoration Centre's National River Restoration Inventory (NRRI) and the UK Environment Agency's River Habitat Survey (RHS) to analyse the relationship between restoration technique and the physical catchment context in which they have been implemented. Specifically we tested the relationship between categories of restoration technique and energy conditions, the relationship between restoration project and degree of channel modification, and whether the associations between restoration and physical catchment attributes have changed over time. Significant associations between categories of restoration technique and catchment variables were found, with direct morphological interventions needed in lower energy conditions; however, the analysis shows no change over time. This work shows that analysis of existing data sets can provide useful information to support the science and practice of river restoration and suggests that further analysis of existing ecological and geomorphological data sets provides an important learning opportunity to strengthen river restoration.     

基于Fuzzy理论的产品UE量化分析

通过建立用户体验模型,得到丰富的体验数据,必须对其进行量化分析,Fuzzy数学理论为该数据的分析提供了模糊评判的标准,使产品设计部门更直观地了解消费者的体验。     

锆合金表面耐事故涂层研究进展

锆合金表面涂层是核电耐事故燃料研究的一个重要技术途径。本文综述了福岛事故后锆合金包壳外表面耐事故涂层的研究进展,依据涂层制备中的涂层材料、制备工艺、涂层性能表征等关键问题逐次展开。首先介绍用于核电锆合金表面的涂层材料,主要包括金属涂层、陶瓷类涂层、合金涂层和多层复合涂层。其次,介绍用于锆合金表面耐事故涂层的制备工艺,主要包括冷喷涂、离子镀、磁控溅射和其他种类的制备工艺。最后,介绍锆合金表面耐事故涂层性能表征方法以及涂层材料和制备工艺对涂层性能影响的研究工作,涂层性能包括涂层表面完整性和关键堆外性能两个方面。本研究进展可为进一步研究与开发锆合金表面耐事故涂层提供重要参考。     

Structural and compositional analysis of (InGa) (AsSb)/GaAs/GaP Stranski–Krastanov quantum dots

We investigated metal-organic vapor phase epitaxy grown (InGa)(AsSb)/GaAs/GaP Stranski–Krastanov quantum dots (QDs) with potential applications in QD-Flash memo...