Artificial neural networks for feature extraction and multivariatedata projection

Classical feature extraction and data projection methods have been well studied in the pattern recognition and exploratory data analysis literature. We propose a number of networks and learning algorithms which provide new or alternative tools for feature extraction and data projection. These networks include a network (SAMANN) for J.W. Sammon's (1969) nonlinear projection, a linear discriminant analysis (LDA) network, a nonlinear discriminant analysis (NDA) network, and a network for nonlinear projection (NP-SOM) based on Kohonen's self-organizing map. A common attribute of these networks is that they all employ adaptive learning algorithms which makes them suitable in some environments where the distribution of patterns in feature space changes with respect to time. The availability of these networks also facilitates hardware implementation of well-known classical feature extraction and projection approaches. Moreover, the SAMANN network offers the generalization ability of projecting new data, which is not present in the original Sammon's projection algorithm; the NDA method and NP-SOM network provide new powerful approaches for visualizing high dimensional data. We evaluate five representative neural networks for feature extraction and data projection based on a visual judgement of the two-dimensional projection maps and three quantitative criteria on eight data sets with various properties.     

Efficient use of commercial electromagnetic simulators for microwave and millimeter-wave circuits

Efficient use of electromagnetic simulators is accomplished by classification of EM problems into three categories—characterization of circuit elements, optimization of circuit elements, and creation of circuit element libraries. Real circuit examples in each of the three categories are given to demonstrate the practical aspects of efficient EM simulations and the computer resources required. © 1995 John Wiley & Sons, Inc.     

Combined arsenic and retinoic acid treatment enhances differentiation and apoptosis in arsenic-resistant NB4 cells

In the acute promyelocytic leukemia (APL) cell line NB4, as well as in APL patients' cells, arsenic trioxide (As2O3) leads to incomplete cell maturation, induction of apoptosis, as well as to the degradation of the oncogenic PML/RARalpha fusion protein. We have isolated an arsenic-resistant NB4 subline (NB4-AsR), which fails to undergo apoptosis, but maintains the partial differentiation response to this drug. When grown in the presence of As2O3, NB4-AsR cells degrade PML/RARalpha, slightly differentiate, and become more sensitive to serum deprivation-induced apoptosis. Similarly, in RA-resistant NB4-R1 cells, RA induced a significant PML/RARalpha degradation and yet failed to induce cell maturation. Thus, As2O3- or retinoic acid (RA)-induced PML/RARalpha degradation may be a prerequisite, but is not sufficient for the full differentiative/apoptotic response to these drugs. Strikingly, RA-triggered differentiation and apoptosis were greatly accelerated in As2O3-treated NB4-AsR cells. The synergism between these two agents in this setting could provide an experimental basis for combined or sequential RA/As2O3 therapies.     

Overt and relational aggression in Russian nursery-school-age children: parenting style and marital linkages

Maternal and paternal parenting styles and marital interactions linked to childhood aggressive behavior as described in Western psychological literature were measured in an ethnic Russian sample of 207 families of nursery-school-age children. Results corroborated and extended findings from Western samples. Maternal and paternal coercion, lack of responsiveness, and psychological control (for mothers only) were significantly correlated with children's overt aggression with peers. Less responsiveness (for mothers and fathers) and maternal coercion positively correlated with relational aggression. Some of these associations differed for boys versus girls. Marital conflict was also linked to more overt and relational aggression for boys. When entered into the same statistical model, more marital conflict (for boys only), more maternal coercion, and less paternal responsiveness were found to be the most important contributors to overt and relational aggression in younger Russian children.     

The anatomy of T-cell activation and tolerance

The mammalian immune system must specifically recognize and eliminate foreign invaders but refrain from damaging the host. This task is accomplished in part by the production of a large number of T lymphocytes, each bearing a different antigen receptor to match the enormous variety of antigens present in the microbial world. However, because antigen receptor diversity is generated by a random mechanism, the immune system must tolerate the function of T lymphocytes that by chance express a self-reactive antigen receptor. Therefore, during early development, T cells that are specific for antigens expressed in the thymus are physically deleted. The population of T cells that leaves the thymus and seeds the secondary lymphoid organs contains helpful cells that are specific for antigens from microbes but also potentially dangerous T cells that are specific for innocuous extrathymic self antigens. The outcome of an encounter by a peripheral T cell with these two types of antigens is to a great extent determined by the inability of naive T cells to enter nonlymphoid tissues or to be productively activated in the absence of inflammation.