Process control and monitoring of reactive crystallization of L‐glutamic acid

The aim of the present study was to investigate feedback control of a reactive crystallization process. The present study built up a control structure needed to control the driving force of reactive crystallization using the feed rate of added acid. The concentration of the crystallizing compound and pH was used to compute feedback in the closed‐loop control of semi‐batch precipitation. The concentration of L ‐glutamic acid was determined from measured MID‐IR ATR‐FTIR spectra based on a multivariate model. Dynamic change of set value was based on the mass of added sulfuric acid and pH. The studied properties of the product crystals were polymorphism and crystal size. The polymorphic composition was analyzed with a Raman spectrometer and was expressed by mass fraction of the α‐polymorph. The obtained results showed that the developed feedback process control system allows effective control of forming of polymorphs. © 2009 American Institute of Chemical Engineers AIChE J, 2010     

Electrically isolated thermally carbonized porous silicon layer for humidity sensing purposes

The resistance of the thermally carbonized porous silicon (TCPSi) against HF was utilized to etch a second porous layer underneath the TCPSi sensing layer. Three oxidation methods were studied to obtain electrically isolated TCPSi sensing layers for humidity sensing purposes. The present study showed that electrochemical oxidation is propitious for such applications. The other two methods, pyridine-assisted vapor and liquid oxidations, resulted in cracking at the interface of the TCPSi and oxidized PSi layers. The TCPSi sensor with an electrically isolated sensing layer was five times more sensitive than a typical TCPSi sensor.     

Increased nuchal translucency as a marker for fetal chromosomal defects

BACKGROUND: Screening for trisomy 21 (Down's syndrome) by measuring maternal serum alpha-fetoprotein, chorionic gonadotropin, and estriol concentrations and then performing chorionic-villus sampling or amniocentesis identifies approximately 60 percent of fetuses with this disorder. We used ultrasonography to detect increased nuchal translucency and cystic hygroma, which are characteristic features of fetuses with chromosomal defects. METHODS: We performed transvaginal ultrasonography in 10,010 unselected adolescents and women less than 40 years of age with live singleton fetuses at 10 to 15.9 weeks of gestation. Increased fetal nuchal translucency was defined as an area of translucency at least 3 mm in width, and cystic hygromas were defined as septated, fluid-filled sacs in the nuchal region. Subjects whose fetuses had these findings were offered fetal karyotyping. Information on pregnancies, deliveries, and neonates was subsequently obtained from hospital records and national birth and malformation registries. RESULTS: Nuchal translucency or cystic hygroma was seen in 76 fetuses (0.8 percent), of which 18 (24 percent) had an abnormal karyotype. The sensitivity for trisomies 21, 18, and 13 combined was 62 percent (13 of 21 fetuses), and the sensitivity for trisomy 21 alone was 54 percent (7 of 13 fetuses). CONCLUSIONS: The use of transvaginal ultrasonography to detect increased nuchal translucency and cystic hygroma is a sensitive test for fetal aneuploidy. It can be done earlier in pregnancy than serum screening, and it decreases the subsequent need for chorionic-villus sampling or amniocentesis.     

Prediction model for the diurnal behavior of the troposphericscintillation variance

Tropospheric scintillation is caused by variations of the refractive index due to turbulence. The only meteorological input parameter for two common current scintillation models by Karasawa et al. (1988) and by the ITU-R is the monthly average of the wet part of the refractivity N_wet at ground level, which is not directly associated with turbulence. The diurnal correlation between N_wet and scintillation variance is very weak. Because clouds and cloud formation are closely associated with the turbulence, quantitative cloud parameters were looked for. Cloud type information based on edited synoptic cloud reports are available from the common database of CDIAC and NCAR. Both diurnal and seasonal variations between scintillation variance and average amount of Cumulus type clouds are well correlated. Using this cloud information together with N_wet, a new method for tropospheric scintillation variance predicting also the diurnal variations is introduced. This model is derived and tested using scintillation measurements at four sites in different climates in Finland, United Kingdom, Japan, and Texas     

Collagenase-3 (matrix metalloproteinase-13) expression is induced in oral mucosal epithelium during chronic inflammation

Increased proliferation of mucosal epithelium during inflammation is associated with degradation of subepithelial connective tissue matrix and local invasion of the epithelial cells. Here we have studied, whether collagenase-3 (MMP-13), a collagenolytic matrix metalloproteinase with an exceptionally wide substrate specificity, is expressed in the epithelium of chronically inflamed mucosa. Examination of human gingival tissue sections from subjects with chronic adult periodontitis with in situ hybridization revealed marked expression of MMP-13 in basal cells of some epithelial rete ridges expanding into connective tissue. Immunohistochemical staining demonstrated that these cells also expressed strongly laminin-5, suggesting that they are actively migrating cells. A strong signal for MMP-13 mRNA was occasionally also noted in the suprabasal epithelial cells facing the gingival pocket, whereas no collagenase-1 (MMP-1) mRNA was detected in any areas of the epithelium. MMP-13 expression was also detected in fibroblast-like cells associated with collagen fibers of the inflamed subepithelial connective tissue. In organ culture of human oral mucosa, MMP-13 mRNA expression was observed in epithelial cells growing into connective tissue of the specimens. Regulation of MMP-13 expression was examined in cultured normal nonkeratinizing epithelial cells isolated from porcine periodontal ligament. In these cells, MMP-13 expression at the mRNA and protein level was potently enhanced (up to sixfold) by tumor necrosis factor-alpha, transforming growth factor-beta(1), and transforming growth factor-alpha and by keratinocyte growth factor in the presence of heparin. In addition, plating periodontal ligament epithelial cells on type I collagen stimulated MMP-13 expression (sevenfold) as compared with cells grown on tissue culture plastic. The results of this study show, that expression of MMP-13 is specifically induced in undifferentiated epithelial cells during chronic inflammation due to exposure to cytokines and collagen. Thus, it is likely that MMP-13 expression is instrumental in the subepithelial collagenolysis and local invasion of the activated mucosal epithelium into the connective tissue.     

Grouping and sequencing PCB assembly jobs with minimum feeder setups

Printed circuit boards are manufactured in automated assembly lines, where high-speed placement machines put components on the boards. These machines are frequently bottlenecks in the production. This is true especially in high-mix low-volume environments, where time consuming setup operations of the machines have to be done repeatedly. Therefore, one can improve productivity with a proper setup strategy. The most popular strategies are the so-called group setup strategy and minimum setup strategy. In this paper, we consider the machine setup problem as a combination of a job grouping problem and a minimum setup problem. We formulate this joint problem as an Integer Programming model, where the objective is to minimize the weighted sum of the number of setup occasions and the total number of component feeder changes. We also present and evaluate hybrid algorithms based on both grouping and minimum setup heuristics. The best results are achieved by a method which uses both these strategies simultaneously.     

Effects of interstimulus interval on somatosensory evoked magnetic fields (SEFs): a hypothesis concerning SEF generation at the primary sensorimotor cortex

Cerebral responses evoked by peripheral stimuli are known to depend critically on the interstimulus interval (ISI). Here we report on the effects of ISI on somatosensory evoked magnetic fields (SEFs) to right median nerve stimulation, obtained in 9 healthy adults with ISIs of 0.15 0.3, 1,3 and 5 s. At the contralateral (left) primary sensorimotor cortex (SMI), the first cortical response, N20m, was stable between the ISIs 0.3 and 5 s, but slightly attenuated at the shortest ISI of 0.15 s. In contrast, the P35m and P60m deflections were very sensitive to changes of the ISI, declining steadily with shortening of the ISI throughout the entire range. These deflections were frequently undetectable at the shortest ISI of 0.15 s. Concomitant with the reductions of P35m and P60m, an N45m deflection was enhanced toward the short ISIs. Responses from second somatosensory cortex (SII) and posterior parietal cortex (PPC) were seen only with ISIs of 1 s or greater, being strongest at the 5 s ISI. Based on known effects of the ISI on intracellular evoked potentials, we present the following tentative model for the generation mechanism of the SMI response: N20m represents early excitatory postsynaptic potentials (EPSPs), P35m early inhibitory postsynaptic potentials (IPSPs), N45m secondary EPSPs and P60m late IPSPs in pyramidal neurones of area 3b. For practical purposes, SEFs from SMI can be obtained with short ISIs, while responses from SII and PPC require an ISI of at least 1 s.     

Effects of two low-fat diets, high and low in polyunsaturated fatty acids, on plasma lipid peroxides and serum vitamin E levels in free-living hypercholesterolaemic men

Diet enriched with polyunsaturated fat may increase the susceptibility of LDL to oxidation. Therefore the effects of two low-fat diets on plasma lipid peroxides in free-living mildly hypercholesterolaemic men (n = 37) were investigated in a randomized single-blind 28-week study. Composition of the diets were (1) American Heart Association (AHA) type 32/10:8:8 (indicating percentages of energy from total fat/saturated fat:monoenes:polyenes in actual diet); (2) low-fat 30/12:8:3. The subjects kept 3-day dietary records five times during the study to estimate the intake of nutrients. Plasma lipid peroxides were measured photometrically as the thiobarbituric-acid reactive substances (TBARS). Levels of serum vitamin E during the study were also determined. Mean change (+/- SD) in serum low density lipoprotein (LDL) cholesterol was similar in both groups (-0.32 +/- 0.76 vs -0.32 +/- 0.87 mmol/l) (AHA type vs low-fat). Level of TBARS decreased (P < 0.05) during the AHA type diet (-8.4 +/- 37.1%) (mean +/- SD) and increased (P = 0.228) during the low-fat diet (+8.7 +/- 27.0%) from 0 to 6 months. The mean intake of total active tocopherols was greater (14.7 +/- 3.7 mg) during the AHA type diet compared to the low-fat diet (7.8 +/- 2.1 mg). Serum vitamin E to LDL cholesterol ratio increased from 8.9 +/- 2.9 to 9.6 +/- 2.4 nmol/mmol (0 vs 6 months) (P = 0.07) during the AHA type diet and from 8.6 +/- 2.6 to 9.3 +/- 2.4 nmol/mmol (P = 0.159) during the low-fat diet.(ABSTRACT TRUNCATED AT 250 WORDS)     

Predictions of radiowave attenuations due to a melting layer ofprecipitation

A melting layer model related to the physical constants and meteorological parameters is employed in this investigation. The specific phase shift, together with the specific attenuation, is computed at 1-100 GHz by using the Mie theory. The additional zenith attenuation, which is the difference between zenith attenuation due to the melting layer and attenuation due to the same thickness of the resulting rain, is comprehensively studied. The ratio of the difference to rain zenith attenuation may be over 1 at 1-5 GHz although the difference is much less than 1 dB. The difference can be over 1 dB at frequencies above 20 GHz. A minimum of the ratio is below 0.05 at frequencies about 40-60 GHz but the ratio can become a value of about 0.1 at 100 GHz. The additional attenuation should be taken into account in satellite-Earth communications and radar remote sensing. The power law parameters of the average specific attenuation of the melting layer and rain specific attenuation are tabulated for three raindrop size distributions at rain rates of below 25 mm/h. The power law method could be utilized in the additional attenuation calculation. It is a good approximation of the Mie theory results at 1-50 GHz and a useful estimate at 50-100 GHz