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91.
Ingo Kuehn Miikka Kotamaki Laurent Schmieder Jean-Jacques Cordier Stefano Chiocchio Leontin Carafa James Klingsmith Laurent Patisson Giuliano Rigoni Thibault Tsedri 《Fusion Engineering and Design》2011,86(6-8):632-635
The ITER site consists of almost 30 buildings to service the Tokamak machine which is located in the centre of the Tokamak Complex facility with the Tokamak-, Diagnostic- and Tritium building.The design of a large part of the ITER plant systems will be executed by the ITER Domestic Agencies or their industrial suppliers under functional specifications provided by the ITER Organization. At the same time, the detailed design of the building is carried out by the European Domestic Agency ‘Fusion for Energy’ (F4E).In order to allow an efficient identification of the ITER configuration as well as to manage the concurrent engineering activities and to simplify the identification and assessment of changes, the design of each ITER plant systems is described in the so-called Configuration Management Models (CMM). These are light CATIA® 3D models that define the required space envelope and the physical interfaces in-between the systems and the buildings.The paper describes the procedure adopted for the control of the baseline configuration of the Tokamak Complex facility and Auxiliary Buildings with their associated plant systems and illustrates the current status as well as recent developments in the different systems. 相似文献
92.
Lewis F Cloutier M Chevallier P Turgeon S Pireaux JJ Tatoulian M Mantovani D 《ACS applied materials & interfaces》2011,3(7):2323-2331
Coatings are known to be one of the more suited strategies to tailor the interface between medical devices and the surrounding cells and tissues once implanted. The development of coatings and the optimization of their adhesion and stability are of major importance. In this work, the influence of plasma etching of the substrate on a plasma fluorocarbon ultrathin coating has been investigated with the aim of improving the stability and the corrosion properties of coated medical devices. The 316 L stainless steel interface was subjected to two different etching sequences prior to the plasma deposition. These plasma etchings, with H(2) and C(2)F(6) as gas precursors, modified the chemical composition and the thickness of the oxide layer and influenced the subsequent polymerization. The coating properties were evaluated using flat substrates submitted to deformation, aging into aqueous medium and corrosion tests. X-ray photoelectron spectroscopy (XPS), time of flight-secondary ion mass spectrometry (ToF-SIMS), ellipsometry, and atomic force microscopy (AFM) were performed to determine the effects of the deformation and the aging on the chemistry and morphology of the coated samples. Analyses showed that plasma etchings were essential to promote reproducible polymerization and film growth. However, the oxide layer thinning due to the etching lowered the corrosion resistance of the substrate and affected the stability of the interface. Still, the deformed samples did not exhibited adhesion and cohesion failure before and after the aging. 相似文献
93.
We derive an exact deterministic nonlinear observer to compute the continuous state of an inertial navigation system based on partial discrete measurements, the so-called strap-down problem. Nonlinear contraction is used as the main analysis tool, and the hierarchical structure of the system physics is systematically exploited. The paper also discusses the use of nonlinear measurements, such as distances to time-varying reference points. 相似文献
94.
Aurore Devocelle Lola Lecru Sophie Ferlicot Thomas Bessede Jean-Jacques Candelier Julien Giron-Michel Hlne Franois 《International journal of molecular sciences》2021,22(21)
Chronic kidney disease (CKD), secondary to renal fibrogenesis, is a public health burden. The activation of interstitial myofibroblasts and excessive production of extracellular matrix (ECM) proteins are major events leading to end-stage kidney disease. Recently, interleukin-15 (IL-15) has been implicated in fibrosis protection in several organs, with little evidence in the kidney. Since endogenous IL-15 expression decreased in nephrectomized human allografts evolving toward fibrosis and kidneys in the unilateral ureteral obstruction (UUO) model, we explored IL-15’s renoprotective role by pharmologically delivering IL-15 coupled or not with its soluble receptor IL-15Rα. Despite the lack of effects on myofibroblast accumulation, both IL-15 treatments prevented tubulointerstitial fibrosis (TIF) in UUO as characterized by reduced collagen and fibronectin deposition. Moreover, IL-15 treatments inhibited collagen and fibronectin secretion by transforming growth factor-β (TGF-β)-treated primary myofibroblast cultures, demonstrating that the antifibrotic effect of IL-15 in UUO acts, in part, through a direct inhibition of ECM synthesis by myofibroblasts. In addition, IL-15 treatments resulted in decreased expression of monocyte chemoattractant protein 1 (MCP-1) and subsequent macrophage infiltration in UUO. Taken together, our study highlights a major role of IL-15 on myofibroblasts and macrophages, two main effector cells in renal fibrosis, demonstrating that IL-15 may represent a new therapeutic option for CKD. 相似文献
95.
Massimo Marezio Edgar T. Alexandre Pierre Bordet Jean-Jacques Capponi Catherine Chaillout Evgueni M. Kopnin Sergio M. Loureiro Paolo G. Radaelli Gustaaf Van Tendeloo 《Journal of Superconductivity and Novel Magnetism》1995,8(4):507-510
Cu and C substitution for Hg in Hg-based cuprate superconductors is discussed. The large Hg Debye-Waller factor usually obtained from refinements based on diffraction data should be interpreted as an indication of carbon substitution for the Hg cations. This assumption is corroborated by HREM, powder x-ray anomalous dispersion, and powder neutron diffraction investigations. 相似文献
96.
Elias Abi Abdallah Christophe Bouvet Samuel Rivallant Bernhard Broll Jean-Jacques Barrau 《Composites Science and Technology》2009,69(7-8):1238-1245
This paper presents an experimental investigation concerning low-velocity impact and quasi-static indentation tests on highly oriented laminates used in aeronautical and aerospace applications. The damage observed in such laminates is very particular. Post mortem analysis were carried out which helped to define an impact damage scenario. Microscopic observations led to explain the mechanism of permanent indentation formation which is a fundamental point of damage tolerance justification. Equivalence between static and dynamic is also discussed. 相似文献
97.
The evolution of the catalytic activity of platinum ribbons towards methane oxidation has been studied as a function of the exposure to hexamethyldisiloxane (HMDS) at various temperatures. Below 950 K, and at moderate exposure, HMDS acts as an inhibitor, the surface is progressively covered by patches of silica and the number of active sites decreases as the exposure to HMDS is increased. Above 950 K, the interaction of platinum with HMDS produces irreversibly the formation of a silica overlayer, the mechanism of the catalytic oxidation of methane is deeply modified. The consequences on the resistance of catalytic methane sensors are analysed as a function of the working conditions. 相似文献
98.
Satyam Suwas Roxane Arruffat-Massion László S. Tóth André Eberhardt Jean-Jacques Fundenberger Werner Skrotzki 《Metallurgical and Materials Transactions A》2006,37(3):739-753
The evolution of crystallographic texture during equal channel angular extrusion (ECAE) using route A has been investigated
experimentally as well as by simulations for three types of materials: pure, commercially pure, and impure (cast) copper.
The ECAE texture of copper can be compared with simple shear textures. However, there are deviations in terms of location
of the respective components. These differences can be nearly reproduced using a recent flow line approach for ECAE deformation
(L.S. Tóth, R. Arruffat-Massion, L. Germain, S.C. Baik, and S. Suwas: Acta Mater., 2004, vol. 52, pp. 1885–98) with the help of the viscoplastic self-consistent polycrystal model. The main texture components
common to all three materials are A1E and BE/BE; the latter ones are significantly stronger in the cast material. The effect of further deformation on texture modification
depends on material variables, such as purity, initial microstructure, and texture. 相似文献
99.
100.