类金刚石膜的制备、性能和应用

本文简单介绍了类金刚石膜的制备方法、并讨论了膜成分、结构、电阻率、硬度、内应力和附着力等性能，总结了类金刚石膜在机械、电子、声学、电子计算机、光学和医学等领域的应用状况以及将来的发展趋势。     

稀土耐热镁合金的开发与应用

介绍了稀土元素的特性和耐热镁合金合金体系设计思路.重点阐述了稀土耐热镁合金的开发与应用现状以及稀土在镁合金体系中的影响机理,指出在Mg-Al系的基础上开发出适合汽车用稀土耐热镁合金是今后重点发展方向.     

Synthesis, characterization and osteoconductivity properties of bone fillers based on alendronate-loaded poly(ε-caprolactone)/hydroxyapatite microspheres

A superior drug controlled release system capable of achieving efficient osteogenesis is in imperative demand because of limited bone substitute tissue for the treatment of bone defect. In the present study, we investigated the potential of using poly(ε-caprolactone)–hydroxyapatite (PCL–HA) composite microspheres as an injectable bone repair vehicle by controlled release of alendronate (AL), a medicine that belongs to the bisphosphonates family. The PCL/HA–AL microspheres were prepared with solid/oil/water emulsion technique, which included two processes: (1) AL was loaded on the hydroxyapatite nanoparticles; (2) the HA–AL complex was built in the PCL matrix. The spherical PCL/HA–AL microspheres were characterized with its significantly improved encapsulation efficiency of hydrophilic AL and better sustained release. Human bone mesenchymal stem cells (hMSCs) were cultured on the surface of these microspheres and exhibited high proliferative profile. Specifically, in osteogenic medium, hMSCs on the surface of PCL/HA–AL microspheres displayed superior osteogenic differentiation which was verified by alkaline phosphatase activity assay. In conclusion, by presenting strong osteogenic commitment of hMSCs in vitro, the PCL/HA–AL microspheres have the potential to be used as an injectable vehicle for local therapy of bone defect.     

一种优化逻辑函数的程序设计与实现

论文提出了EDA中易于计算机实现的逻辑函数优化方法,即在优化过程中引入删劣运算,用锐积运算求质蕴涵项,用选择提炼极值法求最小覆盖,并对循环函数进行处理的优化方法。设计了相应的组合逻辑电路逻辑综合优化程序,大量的测试证明了该方法的正确性和易于计算机实现的有效性。     

面向微博话题传播的重要节点测量研究

为了发现在微博网络中对话题传播有巨大影响力的用户,从网络的拓扑结构出发,对微博平台上话题信息的传播进行了研究,测量了话题传播的网络拓扑结构,并利用紧密中心度和介数中心度对传播过程中参与的用户进行了影响力测量。根据测量分析结果,利用随机游走思想,将两种方法进行优化,计算出一个新的参数叫扩张比,用来评价用户在整个话题传播过程中的影响力,实验结果表明优化后的方法能够有效地发现整个网络中影响力最大的重要节点。研究结果有助于控制话题的传播过程,实现网络营销的利益最大化,以及提供研究个人影响力最大化问题新的思路。     

考虑风电计划跟踪的储能调度模糊控制系统研究

风储联合发电可在一定程度上确保风电功率并网计划的可靠实现,其关键技术离不开有效的储能能量管理与控制.提出了一种储能双层模糊控制策略.首先,利用改进的遗传算法优化自适应神经模糊推理系统,以获得未来风电功率.然后,结合实际储能荷电状态与风电功率并网计划动态跟踪调节需求,经双层模糊控制规则反复修正储能系统吞吐功率,确保储能系...     

Dried Blood Spots as Matrix for Evaluation of Valproate Levels and the Immediate and Delayed Metabolomic Changes Induced by Single Valproate Dose Treatment

The immediate and delayed metabolic changes in rats treated with valproate (VPA), a drug used for the treatment of epilepsy, were profiled. An established approach using dried blood spots (DBS) as sample matrices for gas chromatography/mass spectrometry-based metabolomics profiling was modified using double solvents in the extraction of analytes. With the modified method, some of the previously undetectable metabolites were recovered and subtle differences in the metabolic changes upon exposure to a single dose of VPA between males and female rats were identified. In male rats, changes in 2-hydroxybutyric acid, pipecolic acid, tetratriacontane and stearic acid were found between the control and treatment groups at various time points from 2.5 h up to 24 h. In contrast, such differences were not observed in female rats, which could be caused by the vast inter-individual variations in metabolite levels within the female group. Based on the measured DBS drug concentrations, clearance and apparent volume of distribution of VPA were estimated and the values were found to be comparable to those estimated previously from full blood drug concentrations. The current study indicated that DBS is a powerful tool to monitor drug levels and metabolic changes in response to drug treatment.     

砂土介质中废旧轮胎加筋条带拉拔特性

为减少废旧轮胎大量堆放对环境造成的严重污染及潜在安全隐患,基于废旧轮胎良好的抗拉伸、耐老化及界面粗糙等特性,本研究提出将废旧轮胎切割成条,制成加筋条带,用作土工加筋材料的新型利用方法。通过调整砂土不同密实度条件,对比开展废旧轮胎条带及土工格栅拉拔特性试验研究。结果表明,砂土介质中废旧轮胎条带达到极限拉拔力之前,拉拔位移随拉拔力的增长而线性增长;极限拉拔力统计表明,加筋条带界面抗剪强度符合摩尔-库仑强度准则,并由此建立界面抗剪强度与界面摩擦角及似黏聚力的线性关系。通过对比土工格栅加筋性能,发现废旧轮胎条带的剪应力峰值约为土工格栅的2.5~3.2倍;达到剪应力峰值所需要的位移约为土工格栅的5倍。研究成果验证了废旧轮胎条带作为加筋材料的可行性,为进一步开展理论研究及工程应用奠定了基础。     

机制砂空隙率软测量模型构建及试验研究

机制砂的空隙率是衡量混凝土性能的重要指标。空隙率的在线检测能够提升混凝土性能。现有的测量方法无法对机制砂空隙率进行在线检测。因此,提出一种通过动态图像法建立软测量模型,进而实现空隙率在线检测的方法。首先,采用基于动态图像法原理构建的机制砂形态测量平台来采集机制砂图像。然后,计算机制砂的关键形态参数,选择合适的软测量模型算法。最后,构建并比较不同软测量模型的预测性能。对比结果显示,随机森林模型的准确率最高,预测值和试验值最大误差为0.6%。相较于传统方法,该方法可在机制砂生产线中在线检测空隙率,有效提升混凝土性能。     

一种两级误差放大器结构的LDO设计

基于SMIC 0.18μm CMOS工艺,设计了一种两级误差放大器结构的LDO稳压器。该电路运用两级误差放大器串联方式来改善LDO的瞬态响应性能,采用米勒频率补偿方式提高其稳定性。两级放大器中主放大器运用标准的折叠式共源共栅放大器,决定了电路的主要性能参数;第二级使用带有AB类输出的快速放大器,用来监控LDO输出电压的变化,以快速地响应此变化。电路仿真结果显示:在电源电压为5 V时,输出为1.8 V,输出电压的温度系数为10×10-6/℃;当电源电压从4.5 V到5.5 V变化时,线性瞬态跳变为48 mV;当负载电流从0 mA到60 mA变化时,负载瞬态跳变为5 mV。且环路的相位裕度为74°,整个电路的静态电流为37μA。该电路结构的瞬态跳变电压值远小于其他电路结构,且能实现低功耗供电。