Can a Large Number of Transplanted Mesenchymal Stem Cells Have an Optimal Therapeutic Effect on Improving Ovarian Function?

Mesenchymal stem cells (MSCs) are next-generation treatment in degenerative diseases. For the application of mesenchymal stem cell therapy to degenerative disease, transplantation conditions (e.g., optimized dose, delivery route and regenerating efficacy) should be considered. Recently, researchers have studied the mode of action of MSC in the treatment of ovarian degenerative disease. However, the evidence for the optimal number of cells for the developing stem cell therapeutics is insufficient. The objective of this study was to evaluate the efficacy in ovarian dysfunction, depends on cell dose. By intraovarian transplantation of low (1 × 10⁵) and high (5 × 10⁵) doses of placenta-derived mesenchymal stem cells (PD-MSCs) into thioacetamide (TAA)-injured rats, we compared the levels of apoptosis and oxidative stress that depend on different cell doses. Apoptosis and oxidative stress were significantly decreased in the transplanted (Tx) group compared to the non-transplanted (NTx) group in ovarian tissues from TAA-injured rats (* p < 0.05). In addition, we confirmed that follicular development was significantly increased in the Tx groups compared to the NTx group (* p < 0.05). However, there were no significant differences in the apoptosis, antioxidant or follicular development of injured ovarian tissues between the low and high doses PD-MSCs group. These findings provide new insights into the understanding and evidence obtained from clinical trials for stem cell therapy in reproductive systems.     

N-Functionalization of 5-Aminotetrazoles: Balancing Energetic Performance and Molecular Stability by Introducing ADNP

5-aminotetrazole is one of the most marked high-nitrogen tetrazole compounds. However, the structural modification of 5-aminotetrazole with nitro groups often leads to dramatically decreased molecular stability, while the N-bridging functionalization does not efficiently improve the density and performance. In this paper, we report on a straightforward approach for improving the density of 5-aminotetrazole by introducing 4-amino-3,5-dinitropyrazole. The following experimental and calculated properties show that nitropyrazole functionalization competes well with energetic performance and mechanic sensitivity. All compounds were thoroughly characterized using IR and NMR spectroscopy, elemental analysis, and differential scanning calorimetry (DSC). Two energetic compounds (DMPT-1 and DMPT-2) were further confirmed by implementing single-crystal X-ray diffraction studies. Compound DMPT-1 featured a high crystal density of 1.806 g cm⁻³, excellent detonation velocity (v_D = 8610 m s⁻¹), detonation pressure (P = 30.2 GPa), and impact sensitivity of 30 J.     

数字阵列雷达用电源模块的研究与实现

针对数字阵列雷达中的关键部件数字阵列模块（DAM）提出分布式供电方案,分析了DAM用电源模块的设计难点,针对DAM用电源模块的关键技术—补偿环路设计、脉冲调制输出技术和电磁兼容设计进行了详细讨论,给出了变换器的传递函数、补偿网络的选择和零极点配置方法以及储能解耦电容的设计依据,模块实验结果完全达到设计要求,充分证明了设计方法的正确性。为了实现小体积和良好的散热能力,文中介绍了模块的结构工艺和热设计。模块批量生产结果稳定可靠,证明了技术方案的有效性。     

自动化扫描微测技术在腐蚀科学中的应用——扫描离子选择性电极技术

自动化扫描微测技术(automated scanning micro-test technique,ASMT)是一系列利用选择性/特异性电极检测液体环境中局部电流、离子和分子状态及其活性的技术的总称,可以在不接触被测样品的情况下,不但获得进出样品的局部电流变化,还可以获得各种离子分子的浓度、运动速率及运动方向的信息而进一步表征材料的腐蚀过程,其应用范围较广.为了推广其应用,对自动化扫描微测技术中扫描离子选择性电极技术(scanning ion-selective electrode technique,SIET)的原理及其在金属腐蚀研究中的应用进行了简介.     

基于自适应调光的恒照度LED照明系统设计

本文设计了一个基于自适应调光的恒照度LED照明系统,本照明系统将光照强度的感应,信息的传输,驱动信号的占空比的决策,以及LED的亮度调节等集成于一个系统中,实现了LED照明系统的自适应调光。实验结果表明本照明系统可以根据外界环境光照的强弱自适应调节LED照明系统的光输出强度,保证环境光与照明系统的光的总和是一个不变的量,从而实现整个光照环境的恒照度照明。本文的研究成果在节约照明能源,提高人们的照明体验等方面具有重要的实用意义。     

基于LabVIEW的多路VF/IF系列电路测试系统设计

设计了一种VF/IF系列电路测试系统,计算机通过LabVIEW程序控制电压信号Vin,对三路VF/IF系列电路输出的相应脉冲信号进行采集和处理,实现了VF/IF系列电路功能和参数的自动测试。     

常压室温等离子体快速诱变选育高产单宁酶菌株

采用常压室温等离子体诱变技术处理黑曲霉B0201,选育高产单宁酶突变株,为单宁酶的发酵生产提供优良菌株。确定等离子体处理条件,采用稀释平板培养法挑选突变株,利用变色圈法和分光光度法测定产酶量,获得最佳诱变时间为180 s,正突变率高达19%。通过2%的高浓度单宁酸显色平板初筛850株菌,液态摇瓶发酵复筛90株菌,得到高产单宁酶的菌株B1401。诱变后单宁酶酶活为17.61 U/g,是原始菌株酶活8.94 U/g的2倍左右,且传代菌种产单宁酶稳定性良好。      

Microstructure,phase composition and wear resistance of low valence electron concentration AlxCoCrFeNiSi high-entropy alloys prepared by vacuum arc melting

The low valence electron concentration(VEC)AlxCoCrFeNiSi(x = 0.5,1.0,1.5 and 2.0)high-entropy alloys(HEAs)were designed by the fundamental properties of the con...     

A dynamic problem on the edges of a mode I crack subjected to moving unit-step loads

By the theory of complex functions, a dynamic problem on the edges of a mode I crack subjected to moving unit-step loads are investigated. The Riemann-Hilbert problem is easily formulated by the ways of selfsimilar functions. The analytical solution obtained is rather simple and concise. After the solution was utilized by superposition theorem, the relevant solution on the case of arbitrary loading can be obtained.