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11.
Jones Enrico E.; Ghannam Jess; Nigg Joel T.; Dyer Jennifer F. 《Canadian Metallurgical Quarterly》1993,61(3):381
Articulates a paradigm for single-case research in psychotherapy. A patient diagnosed as having major depressive disorder was seen in an intensive, twice-weekly psychodynamic psychotherapy for 2.5 years. Each session was videotaped, and assessments of patient change were obtained at regular intervals. A time-series analysis was used to model fluctuations in the therapy process to take into account time and the effect of previous events on subsequent changes, thereby preserving the context-determined meaning for therapist and patient actions. A bidirectional analysis of causal effects shows that the influence processes between therapist and patient are mutual and reciprocal and suggests that the effect of the patient on the therapist and on the process has not been made sufficiently explicit in previous models of process and change. The potential of intensive single-case designs for uncovering causal effects in psychotherapy is demonstrated. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
12.
Chun-Ren Chen Joel L. Zatz Eugene Reilly 《Drug development and industrial pharmacy》1993,19(11):1265-1282
This potential for ion-pairing between dyclonine, a local anesthetic, and pharmaceutical dyes commonly used in liquid pharmaceutical formulations was examined. Occurrence of ion-pairing at a pH of 3 was confirmed by shift of the absorption maximum of all five sulfonate-containing dyes, and by measurements of octanol/water partition coefficient and surface tension. There was also an increase in the uptake of dyclonine by phosphatidylcholine liposomes in the presence of a dye (tartrazine) at pH 3 but not at pH 7, where the uncharged anesthetic is dominant. 相似文献
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According to D. E. Broadbent's (1958) selective filter theory, people do not process unattended stimuli beyond the analysis of basic physical properties. This theory was later rejected on the basis of numerous findings that people identify irrelevant (and supposedly unattended) stimuli. A careful review of this evidence, however, reveals strong reasons to doubt that these irrelevant stimuli were in fact unattended. This review exposed a clear need for new experiments with tight control over the locus of attention. The authors present 5 such experiments using a priming paradigm. When steps were taken to ensure that irrelevant stimuli were not attended, these stimuli produced no priming effects. Hence, the authors found no evidence that unattended stimuli can be identified. The results support a modern version of Broadbent's selective theory, updated to reflect recent research advances. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Predd Joel Pfleeger Shari Lawrence Hunker Jeffrey Bulford Carla 《Security & Privacy, IEEE》2008,6(4):66-70
This column goes beyond previous insider analyses to identify a framework for a taxonomy of insider threats including both malicious and inadvertent actions by insiders that put organizations or their resources at some risk. The framework includes factors reflecting the organization, the individual, the information technology system, and the environment. 相似文献
17.
Explored whether males' satisfaction with an exchange relationship is more dependent on the equity of that relationship, relative to females'. 26 male and 25 female members of 1 of 3 business lead and referral clubs (1 all female, 1 primarily male, and 1 approximately equal in males and females) rated their own and others' inputs and outcomes into the exchange relationship, as well as their satisfaction with the relationship. Results indicate that satisfaction was lower in a negatively inequitable than equitable relationship and slightly lower in an equitable than positively inequitable relationship. As predicted, the relationship of equity and satisfaction was considerably more pronounced for male than female club members. Further analyses revealed that the equity-satisfaction relationship was especially (a) pronounced for males in the primarily male group and (b) weak for females in an all-female group. The latter findings suggest that the salience of the equity norm may be a joint function of the sex of both members of an exchange relationship. (13 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
18.
Clifford E Felder Simone A Botti Shneior Lifson Israel Silman Joel L Sussman 《Journal of molecular graphics & modelling》1997,15(5):318-327
The electrostatic potentials for the three-dimensional structures of cholinesterases from various species were calculated, using the Delphi algorithm, on the basis of the Poisson–Boltzmann equation. We used structures for Torpedo californica and mouse acetylcholinesterase, and built homology models of the human, Bungarus fasciatus, and Drosophila melanogaster acetylcholinesterases and human butyrylcholinesterase. All these structures reveal a negative external surface potential, in the area around the entrance to the active-site gorge, that becomes more negative as the rim of the gorge is approached. Moreover, in all cases, the potential becomes increasingly more negative along the central axis running down the gorge, and is largest at the base of the gorge, near the active site. Ten key acidic residues conserved in the sequence alignments of AChE from various species, both in the surface area near the entrance of the active-site gorge and at its base, appear to be primarily responsible for these potentials. The potentials are highly correlated among the structures examined, down to sequence identities as low as 35%. This indicates that they are a conserved property of the cholinesterase family, could serve to attract the positively charged substrate into and down the gorge to the active site, and may play other roles important for cholinesterase function. 相似文献
19.
Joel 《Journal of Parallel and Distributed Computing》2005,65(12):1601-1606
Lee and Batcher have designed networks that efficiently merge k separately provided sorted sequences of known lengths totalling n. We show that the design is still possible, and in fact easier to describe, if we do not make use of the lengths, or even the directions of monotonicity, of the individual sequences—the sequences can be provided in a single undelimited concatenation of length n. The depth of the simplest resulting network to sort sequences that are “k-tonic” and of length n is , generalizing Batcher's 1968 results for the extreme values of k (k=2 corresponding to merging, and k=n/2 corresponding to general sorting).The exposition is self-contained and can serve even as an introduction to sorting networks and Batcher's results. 相似文献
20.
Using a novel second-order mobility theory that was recently developed by the authors, this article develops new lower bounds on the number of frictionless fingers required to immobilize generic planar objects. We show that any generic smooth or polygonal planar object can be immobilized with three convex fingers or fixtures that have sufficiently flat curvature. Further, if it is possible to specify the fingertip curvature, then any generic smooth or polygonal object can be immobilized with two, possibly concave, fingers. © 1995 John Wiley & Sons, Inc. 相似文献