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Julius Juma Okello Felix Mwala Shiundu Janet Mwende Carl Johan Lagerkvist Rose Adhiambo Nyikal Penina Muoki John Mburu Jan Low Guy Hareau Simon Heck 《International Journal of Food Science & Technology》2021,56(3):1432-1446
This 2018 study, conducted in six Tusky's supermarkets in Nairobi, Kenya, combined the Just-About-Right, Penalty and Mean-End-Chain analyses to examine the quality and psychosocial factors influencing the purchase of a novel bread made from orange-fleshed sweet potato (OFSP), a biofortified crop, focusing on sixty-one male and eighty female urban OFSP bread buyers recruited at point of purchase. It finds that sensory and psychosocial factors drive purchasing decisions and that some of the bread's sensory characteristics are misaligned with consumers' expectations. It also finds that women and men’s evaluations of the bread's characteristics are different, as are their motivations for purchase. However, good sensory attributes and the knowledge of the bread's nutritional value were key drivers. Some misaligned characteristics reveal levers for the reformulation of the bread and present opportunities for segmenting the market. Several other implications of the findings for policy and future improvement of the bread are discussed. 相似文献
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Robert Lassfolk Sara Bertuzzi Dr. Ana Ardá Prof. Johan Wärnå Prof. Jesús Jiménez-Barbero Prof. Reko Leino 《Chembiochem : a European journal of chemical biology》2021,22(20):2986-2995
Acyl group migration is a fundamental phenomenon in carbohydrate chemistry, recently shown to take place also between two non-adjacent hydroxyl groups, across the glycosidic bond, in a β-(1→4)-linked mannan trisaccharide model compound. With the central mannoside unit containing acetyl groups at the O2 and O3 positions, the O2-acetyl was in the earlier study shown to migrate to O6 of the reducing end. Potential implications of the general acyl migration process on cell signaling events and plant growth in nature are intriguing open questions. In the present work, migration kinetics in this original trisaccharide model system were studied in more detail together with potential interactions of the model compound and the migration products with DC-SIGN lectin. Furthermore, we demonstrate here for the first time that similar migration may also take place in native polysaccharides, here represented by galactoglucomannan from Norway spruce. 相似文献
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Nathalie Acevedo Giovanni Scala Simon Kebede Merid Paolo Frumento Sren Bruhn Anna Andersson Christoph Ogris Matteo Bottai Gran Pershagen Gerard H. Koppelman Erik Meln Erik Sonnhammer Johan Alm Cilla Sderhll Juha Kere Dario Greco Annika Scheynius 《International journal of molecular sciences》2021,22(2)
DNA methylation changes may predispose becoming IgE-sensitized to allergens. We analyzed whether DNA methylation in peripheral blood mononuclear cells (PBMC) is associated with IgE sensitization at 5 years of age (5Y). DNA methylation was measured in 288 PBMC samples from 74 mother/child pairs from the birth cohort ALADDIN (Assessment of Lifestyle and Allergic Disease During INfancy) using the HumanMethylation450BeadChip (Illumina). PBMCs were obtained from the mothers during pregnancy and from their children in cord blood, at 2 years and 5Y. DNA methylation levels at each time point were compared between children with and without IgE sensitization to allergens at 5Y. For replication, CpG sites associated with IgE sensitization in ALADDIN were evaluated in whole blood DNA of 256 children, 4 years old, from the BAMSE (Swedish abbreviation for Children, Allergy, Milieu, Stockholm, Epidemiology) cohort. We found 34 differentially methylated regions (DMRs) associated with IgE sensitization to airborne allergens and 38 DMRs associated with sensitization to food allergens in children at 5Y (Sidak p ≤ 0.05). Genes associated with airborne sensitization were enriched in the pathway of endocytosis, while genes associated with food sensitization were enriched in focal adhesion, the bacterial invasion of epithelial cells, and leukocyte migration. Furthermore, 25 DMRs in maternal PBMCs were associated with IgE sensitization to airborne allergens in their children at 5Y, which were functionally annotated to the mTOR (mammalian Target of Rapamycin) signaling pathway. This study supports that DNA methylation is associated with IgE sensitization early in life and revealed new candidate genes for atopy. Moreover, our study provides evidence that maternal DNA methylation levels are associated with IgE sensitization in the child supporting early in utero effects on atopy predisposition. 相似文献
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Avramelos Vasileios De Praeter Johan Van Wallendael Glenn Lambert Peter 《Multimedia Tools and Applications》2020,79(19-20):12847-12867
Multimedia Tools and Applications - Computational imaging and light field technology promise to deliver the required six-degrees-of-freedom for natural scenes in virtual reality. Already existing... 相似文献
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The direct‐drive radial flux synchronous generator is considered as the modern wind turbine drive train. Both the electrically (e.g., Enercon) and permanent magnet (PM; e.g., Siemens) excited direct‐drive generators are gaining popularity on the market today. Compared with the matured geared counterpart, the electrically excited direct‐drive generator is heavier and more expensive but more reliable per unit capacity. The PM‐excited generator is expensive, is simpler in electromechanical design, has a high power‐to‐weight ratio, and yields a higher energy conversion efficiency than its electrically excited equivalent. The PM generator technology has the potential to yield the highest energy‐to‐cost ratio. However, standardization of this direct‐drive generator parts/subassemblies may overcome the existing cost barrier. Most current literature focuses on PM generator wind turbine technology, specifically on generator energy conversion optimization, and the scalability of technologies to capacities in access of 5 MW. Strangely, PM generator's mass and cost reductions through optimized structural design incorporating manufacturing, transportation, and installation constraints are less studied. This paper solely focuses on the mechanical and structural design aspects of large radial flux synchronous PM generators specific to direct‐drive wind turbines. Generator topologies such as the common iron‐cored and unconventional air‐cored generator are discussed. However, design considerations specific to the iron‐cored generator topology are studied. The design considerations investigated involve the geometries and the configurations of rotor/stator active and inactive structures, the interfaces, and the conductor/PM mounting methods. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
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The telephone game,or clear as crystal? How to effectively craft responses to reviewer comments
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This brief note focuses on how to communicate with reviewers through the response letter. Specifically, we elaborate on how to minimize the risk that reviewers underestimate the quality of the study because of poor communication in the response letter. We outline ideas for how to plan and organize a revision, and then crafting the response letter. We organize the discussion around how common writing rules, such as “Make it simple to read” and “Write for the target audience”, may apply to response letters but need adaptation to be effective. In summary, while the changes made in the actual paper are most important in any revision, this note provides an additional resource to use in order to increase the chances that the revised paper reaches its greatest potential. 相似文献