Form-Profiling of Optics Using the Geometry Measuring Machine and the M-48 CMM at NIST

We are developing an instrument, the Geometry Measuring Machine (GEMM), to measure the profile errors of aspheric and free form optical surfaces, with measurement uncertainties near 1 nm. Using GEMM, an optical profile is reconstructed from local curvatures of a surface, which are measured at points on the optic’s surface. We will describe a prototype version of GEMM, its repeatability with time, a measurements registry practice, and the calibration practice needed to make nanometer resolution comparisons with other instruments. Over three months, the repeatability of GEMM is 3 nm rms, and is based on the constancy of the measured profile of an elliptical mirror with a radius of curvature of about 83 m. As a demonstration of GEMM’s capabilities for curvature measurement, profiles of that same mirror were measured with GEMM and the NIST Moore M-48 coordinate measuring machine. Although the methods are far different, two reconstructed profiles differ by 22 nm peak-to-valley, or 6 nm rms. This comparability clearly demonstrates that with appropriate calibration, our prototype of the GEMM can measure complex-shaped optics.     

Designing robustly stabilising controllers for LTI spatially distributed systems using coprime factor synthesis

This paper considers the design of feedback controllers for linear, time-invariant, spatially distributed systems in an approach which generalises the H^∞-framework and in particular the H^∞ loop-shaping method. To this end, we introduce a class of spatially distributed system models called finite dimensional, distributed, linear, time-invariant systems. Sensors and actuators are considered to be part of the controller, rather than part of the plant, and thus the controller we wish to design is itself a spatially distributed system. Optimising over placements and shapes of the sensor and actuator spatial distribution functions is an integrated part of the controller design procedure. As an illustrative design example, we present the feedback stabilisation of an electrostatically destabilised, electrically conducting membrane.     

Physiological cost of energy-equivalent noise exposures with a rating level of 85 dB(A):: Hearing threshold shifts associated with energetically negligible continuous and impulse noise

In industry continuous or impulse noise does not occur exclusively; rather it is a combination of both. If low-level continuous noise or impulse noise (below 120 dB) is added to an already existing high-level continuous noise this often numerically causes no essential increase in the rating level. Yet, it cannot be expected that also aural strain of these exposures is always negligible. Therefore, in a cross-over test series, ten male subjects (Ss) were exposed to white noise of 94 dB(A) for 1 h (TS I), energy-equivalent to an 8 h-rating level L_Ard of 85 dB(A). In a second test series (TS II) the same exposure was combined with 900 energetically negligible 5-ms impulses with a noise level of 113 dB(A) which increased the rating level by only 0.4 dB. The noise exposure of TS I and TS II was followed by an idealized resting phase in a soundproof cabin. In a third test series (TS III) the continuous noise of 94 dB(A) / 1 h was followed by 3 h of white noise at 70 dB(A). Such an additional load increases the L_Ard by merely 0.1 dB to 85.1 dB(A). In all three test series, the noise-induced temporary threshold shift (TTS₂) and its restitution were measured. The continuous noise exposure of 94 dB(A) for 1 h was associated with a TTS₂ of around 20 dB which disappeared completely after about 2 h. The additional impulse noise caused a small increase in the TTS₂ and a prolongation of the restitution time. The maximum mean temporary threshold shift for the group increased only slightly (from 22.5 to 25.9 dB, which nevertheless can be statistically proven at a significance level of p 0.99). Yet, more importantly, the restitution time increased from 126 to 175 min, i. e. 3 h, which can be statistically proven at a significance level of p0.95. The TTS₂-values of TS III did not differ significantly from those resulting from TS I. That was expected as the conditions up to that point in time were identical. But due to the additional subsequent exposure, the mean restitution time increased considerably from 126 min up to 240 min (4 h). The mean total physiological cost represented by the integrated restitution temporary threshold shift (IRTTS) increased in TS II by approximately 40% and in TS III even by 140%.

Relevance to industry

The results of the study show that levels of noise which have no influence on the rating level which traditionally is calculated according to the energy-equivalence principle are often of great importance, as they can lead to considerably prolonged restitution times. Therefore, the purely energy-equivalent determination of the rating level of both impulse noise and low sound levels can lead to an underestimation of latent problems so that over time a reversible TTS can evolve into a permanent threshold shift. The results are also of importance for the acoustic design of break rooms for noise-exposed workers. There should be conditions that allow an undisturbed restitution of hearing.     

Biomarkers for the Diagnosis of Alzheimer’s Disease in Clinical Practice: The Role of CSF Biomarkers during the Evolution of Diagnostic Criteria

Alzheimer’s disease (AD) is a progressive condition and the most common cause of dementia worldwide. The neuropathological changes characteristic of the disorder can be successfully detected before the development of full-blown AD. Early diagnosis of the disease constitutes a formidable challenge for clinicians. CSF biomarkers are the in vivo evidence of neuropathological changes developing in the brain of dementia patients. Therefore, measurement of their concentrations allows for improved accuracy of clinical diagnosis. Moreover, AD biomarkers may provide an indication of disease stage. Importantly, the CSF biomarkers of AD play a pivotal role in the new diagnostic criteria for the disease, and in the recent biological definition of AD by the National Institute on Aging, NIH and Alzheimer’s Association. Due to the necessity of collecting CSF by lumbar puncture, the procedure seems to be an important issue not only from a medical, but also a legal, viewpoint. Furthermore, recent technological advances may contribute to the automation of AD biomarkers measurement and may result in the establishment of unified cut-off values and reference limits. Moreover, a group of international experts in the field of AD biomarkers have developed a consensus and guidelines on the interpretation of CSF biomarkers in the context of AD diagnosis. Thus, technological advancement and expert recommendations may contribute to a more widespread use of these diagnostic tests in clinical practice to support a diagnosis of mild cognitive impairment (MCI) or dementia due to AD. This review article presents up-to-date data regarding the usefulness of CSF biomarkers in routine clinical practice and in biomarkers research.