An Electrostatic Lens for Focusing Charged Particles in a Mass Spectrometer

The ability to transmit particles into the ablation region of an aerosol mass spectrometer determines in part the lower size limit for particles that can be analyzed. A large fraction of small particles (< 100 nm) are lost due to processes such as Brownian diffusion that broaden the particle beam. In this work, electrostatic focusing is used to overcome the limits of aerodynamic focusing in the analysis of nanometer-sized particles by aerosol mass spectrometry. A simple tube lens is used to focus charged particles into the ablation laser beam path. The diameter of the focused beam is smaller than the fundamental aerodynamic limit imposed by Brownian motion. Measured enhancements of the hit rate for particles between 21 and 33 nm diameter are between 3 and 6. These values are lower limits for the true enhancements. The lens is also energy selective and can be used to select the mass (size) of the particles being analyzed.     

Social networks and the implementation of environmental technology

A study of 83 firms in the North American electronics industry that have implemented environmentally “clean” process technology found that social networks have a significant positive impact on implementation success. This paper presents evidence that some types of social networks influence implementation success more than others. More specifically, interfirm networks composed of both suppliers and competitors were significantly correlated with the routinization and incorporation of alternative technical solutions to reducing ozone depleting chlorofluorocarbons (CFCs). This only held in situations where the complexity of the implementation was relatively high. Intrafirm and local social networks were not significant. The utilization of a network of publicly accessible sources of information and expertise had a negative impact. Brief case studies from field research are provided to help explain these results     

Teacher ratings predict peer ratings of aggression at 3-year follow-up in boys with attention deficit disorder with hyperactivity.

Compared initial and 3-yr follow-up peer ratings of 19 boys, who were in Grades 1–3 at the beginning of the study, who had attention deficit disorder with hyperactivity (ADDH). When the entire group was considered, nominations on the Aggression and Likability factors of a pupil evaluation inventory improved. Subgroups were created using teacher ratings on an aggression scale. Peer ratings of Aggression improved for Ss whom teachers rated below the median on the aggression scale but not for Ss rated above the median. Subgroups reflecting other teacher and peer ratings were less effective in predicting differential change in peer ratings of ADDH Ss. (8 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A novel feed for a multifrequency hybrid resonator antenna

A novel feed technique for a hybrid resonator antenna is proposed and developed. The antenna consists of microstrip-patch radiator and a pair of twin resonator slots. The proposed feed mechanism is based on a new coupling aperture technique, in which a single microstrip feed line is etched on the same side of the substrate as the radiating patches. The patches are coupled to the feed line through a twin slots located in the ground plane. By selecting suitable structure parameters for the slots and the patches, multifrequency operation is obtained. The proposed antenna structure is suitable for the development of large antenna arrays.     

The science and practice of empirically supported treatments.

The impact on Canadian professional psychological treatment practices of the American Psychological Association""s Division 12 (Clinical Psychology) Task Force""s development of criteria and listings for empirically supported psychological treatments, along with other industrial efforts to standardize the identification of treatments with established efficacy is described in the article by J. Hunsley et al (see record 1999-01869-001). Here Hunsley et al extend their previous discussion and reply to other commentaries (see records 1999-01869-002, 1999-01869-003, 1999-01869-004, 1999-01869-005, 1999-01869-006) by viewing the current emphases in the Canadian health care system on accountability and empirically supported treatment (ESTs) as an unparalleled opportunity for professional psychology to deliver on its birthright. The generalizability of US experiences to Canadian contexts is discussed. Clinical practice guidelines should and will become the norm for providing evidence-based services in psychology, yet it would be impossible to develop such a guideline without empirical evidence proving that there are "best" interventions for a given problem. Canadian research issues in this light are discussed along with future challenges to professional psychology in Canada. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Expect the worse or hope for the best? Prenatal diagnosis of geleophysic dysplasia

Geleophysic dysplasia is a rare, autosomal recessive disorder which causes disproportionate short stature associated with severe physical handicaps, but is compatible with survival into adulthood. We present a case, a first-born child, where genetic counselling difficulties arose following ultrasound recognition of short-limbed dwarfism in association with polyhydramnios and an initial incorrect prenatal diagnosis of lethal chondrodysplasia. After birth of the surviving affected infant, the parents had great difficulty accepting that there had been a prenatal misdiagnosis and they were greatly disappointed by our inability to predict the postnatal survival of an infant to whom no hope of life had previously been given. The correct diagnosis was not made until the proband was nearly 1 year old, and the true prognosis then became clearer. This experience underlines the relative ease of prenatal recognition of skeletal growth abnormalities compared with the considerable difficulties experienced in reaching a precise diagnosis. Thus, following prenatal diagnosis of unspecified chondrodysplasia when parents seek definite information about the prognosis, the temptation to be either overpessimistic or overoptimistic should be avoided.     

Does stress lead to a loss of team perspective?

One of the more well-established findings in the research literature is that stress leads to a restriction or narrowing of attentional focus. In the present study, we extend this research to the group context. We propose that, in a team environment, the narrowing of attention induced by stress may result in a shift in perspective from a broad team perspective to a more narrow or individualistic self-focus, and this loss of team perspective may result in degraded team performance. The results of an empirical study found that stress resulted in a narrowing of team perspective and that team perspective was a significant predictor of team performance. Moreover, when the effects of team perspective were controlled, the effects of stress on team performance were substantially weakened. These results suggest that one way in which stress impacts team performance is by narrowing or weakening the team-level perspective required for effective team behavior. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Vaccination for experimental gliomas using GM-CSF-transduced glioma cells

Within the pituitary, folliculostellate (FS) cells are considered to regulate the intercellular communication between endocrine cells by paracrine mechanisms. One of the possible paracrine factors involved, could be interleukin-6 (IL-6) which is produced by these cells. Since IL-6 has been shown to be a growth factor of pituitary cells, we have determined whether IL-6 can also influence FS cell proliferation. To test this, a FS cell-like mouse pituitary cell line (TtT/GF cells) was used that exhibits most characteristics of normal FS cells. Under serum-free conditions the proliferation of TtT/GF cells is critically dependent on the initial seeding density: cells seeded at low density do not grow at all whereas cells seeded at high density proliferate with maximal doubling times of 34 hrs. Mouse IL-6 (mIL-6) stimulated only low density cell cultures in a dose and time dependent manner. For cells seeded at high density, exogenously added IL-6 may have failed to stimulate growth because of endogenously produced mIL-6. Conditioned medium from TtT/GF cells, in which mIL-6 concentrations up to 1017 pg/ml were measured, stimulated the proliferation of TtT/GF cells, indicating an autocrine growth stimulatory mechanism. A neutralizing mIL-6 antibody partially suppressed the growth of TtT/GF cells seeded at high density and partially reduced the growth stimulatory activity of TtT/GF conditioned medium. Thus, IL-6 is one but not the only factor that is involved in the autocrine growth stimulatory loop. The relevance of this mechanism for normal FS cells and its physiological consequence needs to be elucidated.