Development of an Active Thermoplastic Film with Oxygen Scavengers Made of Activated Carbon and Sodium Erythorbate

An active thermoplastic film made of low‐density polyethylene (LDPE) filled with oxygen scavengers made of powdered activated carbon (PAC) impregnated with sodium erythorbate (SE) was developed for packaging applications. Initial tests indicated that the impregnation of PAC with SE enhanced the heat resistance of SE, thereby allowing processing at temperatures typical of LDPE manufacturing. Subsequently, LDPE films with PAC/SE particles were manufactured in coupons that represented a typical juice package, and experiments indicated that these films absorbed 3.57 mg of oxygen in 11 days. This amount corresponded to 80% the concentration of oxygen in the headspace of the package. Furthermore, findings indicated that active particles alone have 10 times higher oxygen absorption capacity than the active LDPE film. Finally, the physical properties of the film were characterized by microscopy where oxygen scavengers showed a good dispersion within the matrix. However, 20 wt.% of these active particles decreased tensile strength of the film by 53%. Copyright © 2014 John Wiley & Sons, Ltd.     

Loxin Reduced the Inflammatory Response in the Liver and the Aortic Fatty Streak Formation in Mice Fed with a High-Fat Diet

Oxidized low-density lipoprotein (ox-LDL) is the most harmful form of cholesterol associated with vascular atherosclerosis and hepatic injury, mainly due to inflammatory cell infiltration and subsequent severe tissue injury. Lox-1 is the central ox-LDL receptor expressed in endothelial and immune cells, its activation regulating inflammatory cytokines and chemotactic factor secretion. Recently, a Lox-1 truncated protein isoform lacking the ox-LDL binding domain named LOXIN has been described. We have previously shown that LOXIN overexpression blocked Lox-1-mediated ox-LDL internalization in human endothelial progenitor cells in vitro. However, the functional role of LOXIN in targeting inflammation or tissue injury in vivo remains unknown. In this study, we investigate whether LOXIN modulated the expression of Lox-1 and reduced the inflammatory response in a high-fat-diet mice model. Results indicate that human LOXIN blocks Lox-1 mediated uptake of ox-LDL in H4-II-E-C3 cells. Furthermore, in vivo experiments showed that overexpression of LOXIN reduced both fatty streak lesions in the aorta and inflammation and fibrosis in the liver. These findings were associated with the down-regulation of Lox-1 in endothelial cells. Then, LOXIN prevents hepatic and aortic tissue damage in vivo associated with reduced Lox-1 expression in endothelial cells. We encourage future research to understand better the underlying molecular mechanisms and potential therapeutic use of LOXIN.     

Improved bushing models for general multibody systems and vehicle dynamics

The development and computational implementation, on a multibody dynamics environment, of a constitutive relation to model bushing elements associated with mechanical joints used in the models of road and rail vehicles is presented here. These elements are used to eliminate vibrations in vehicles, due to road irregularities, to allow small misalignment of axes, to reduce noise from the transmission, or to decrease wear of the mechanical joints. Bushings are made of a special rubber, used generally in energy dissipation, which presents a nonlinear viscoelastic relationship between the forces and moments and their corresponding displacements and rotations. In the methodology proposed here a finite element model of the bushing is developed in the framework of the finite element code ABAQUS to obtain the constitutive relations of displacement/rotation versus force/moment for different loading cases. The bushing is modeled in a multibody code as a nonlinear restrain that relates the relative displacements between the bodies connected with the joint reaction forces, and it is represented by a matrix constitutive relation. The basic ingredients of the multibody model are the same vectors and points relations used to define kinematic constraints in any multibody formulation. One particular, and relevant, characteristic of the formulation now presented is its ability to represent standard kinematic joints, clearance, and bushing joints just by defining appropriate constitutive relations. Spherical, revolution, cylindrical, and translational bushing joints are modeled, implemented, and demonstrated through the simulation of two multibody models of a road vehicle, one with perfect kinematic joints for the suspension sub-systems, and other with bushing joints. The tests conducted include an obstacle avoidance maneuver and a vehicle riding over bumps. It is shown that the bushing models for vehicle multibody models proposed here are accurate and computationally efficient so that they can be included in the vehicle models leading reliable simulations.     

Identification of Structural and Molecular Signatures Mediating Adaptive Changes in the Mouse Kidney in Response to Pregnancy

Pregnancy is characterized by adaptations in the function of several maternal body systems that ensure the development of the fetus whilst maintaining health of the mother. The renal system is responsible for water and electrolyte balance, as well as waste removal. Thus, it is imperative that structural and functional changes occur in the kidney during pregnancy. However, our knowledge of the precise morphological and molecular mechanisms occurring in the kidney during pregnancy is still very limited. Here, we investigated the changes occurring in the mouse kidney during pregnancy by performing an integrated analysis involving histology, gene and protein expression assays, mass spectrometry profiling and bioinformatics. Data from non-pregnant and pregnant mice were used to identify critical signalling pathways mediating changes in the maternal kidneys. We observed an expansion of renal medulla due to proliferation and infiltration of interstitial cellular constituents, as well as alterations in the activity of key cellular signalling pathways (e.g., AKT, AMPK and MAPKs) and genes involved in cell growth/metabolism (e.g., Cdc6, Foxm1 and Rb1) in the kidneys during pregnancy. We also generated plasma and urine proteomic profiles, identifying unique proteins in pregnancy. These proteins could be used to monitor and study potential mechanisms of renal adaptations during pregnancy and disease.     

Optimization of the material flow in a manufacturing plant by use of artificial bee colony algorithm

To survive in today’s competitive global market, companies must perform strategic changes in order to increase productivity, eliminating wasted materials, time, and effort. This study will examine how to optimize the time and effort required to supply raw material to different production lines in a manufacturing plant in Juarez, Mexico by minimizing the distance an operator must travel to distribute material from a warehouse to a set of different production lines with corresponding demand. The core focus of this study is similar to that of the Vehicle Routing Problem in that it is treated as a combinatorial optimization problem. The artificial bee colony algorithm is applied in order to find the optimal distribution of material with the aim of establishing a standard time for this duty by examining how this is applied in a local manufacturing plant. Results show that using this approach may be convenient to set standard times in the selected company.     

Criticality and threat analysis on utility tunnels for planning security policies of utilities in urban underground space

A utility tunnel is defined as an underground structure containing one or more utilities, permitting the installation, maintenance and removal of the systems without the necessity of making street cuts or excavations. These underground facilities contain all essential utilities serving large urban areas collected together in a tunnel; therefore they are an inviting target for sabotage or vandalism. This paper proposes an expert system combining color-coded scales, Delphi and AHP methods to analyze criticality and threats on utility tunnels to support planning of security policies for utilities in urban subsurface.     

Control of attendance applied in higher education through mobile NFC technologies

This paper presents an improved attendance control system, required for continuous evaluation which has become compulsory following the Bologna Process. It provides a solution based on NFC technology and is based on a real project developed and pilot tested at the “Universidad Pontificia de Salamanca, Campus Madrid”.     

SWTRACK: An intelligent model for cargo tracking based on off-the-shelf mobile devices

Logistics represent the biggest cost for transportation companies. Companies are investing in monitoring and tracking systems aiming at improving services, reducing costs and ensuring the safety in cargos transports. This article presents an intelligent model to obtain the position of vehicles, using off-the-shelf mobile devices named SWTRACK. The proposal allows distributors companies to track loads and to have real-time information about their whereabouts during a travel. SWTRACK presents an automatic travel management to initialize and finish travels without user interaction. Furthermore, it provides a mechanism to monitor detours in planned routes and to send alarms notification through mobile devices. To build that mechanism, we studied the Geofence concept and existing techniques to prepare two solutions based on continuous monitoring. Those solutions were compared and discussed. We also conducted a model evaluation using off-the-shelf mobile devices. Moreover, we provide an impact analysis regarding GPS precision and battery power consumption. In the end, we show that the proposed model generates a reliable system for tracking vehicles.     

Constraint-wrench analysis of robotic manipulators

The constraint-wrench analysis of mechanisms, with focus on parallel robots, is the subject of this paper. Although the method proposed here can be generalized for parallel robots with multiple-loop kinematic chains, here, single-loop chains are targeted. To this end, a novel representation of the constraints imposed by the kinematic pairs is introduced. With this representation, the constraint matrix of a mechanism is readily derived. For the calculation of the constraint wrenches, by means of the constraint matrix and based on the Newton–Euler formulation, a new procedure is introduced. As a case study, the constraint wrench analysis of the McGill Schönflies Motion Generator (SMG), while undergoing a test cycle adopted by the industry, is conducted.