A thrombolytic decision tree.

We constructed a decision analysis model based on data in the medical literature to estimate the possible outcomes of thrombolytic therapy in patients 50 to 80 years old with possible myocardial infarction. We used the model to test the most likely effects of treatment (determined by averaging the values in reports of large studies) and the worst effects reported so far. The program begins by asking the patient's age, the hours from the onset of pain, and the probability of acute myocardial infarction. It then provides an opportunity to perform sensitivity analyses by changing the values for these variables and for the probability of death in the absence of thrombolytic therapy, as well as for the probability of major stroke and hemorrhage. The counterintuitive findings observed with this program are that the benefits of thrombolytic therapy increase with age and that young patients derive surprisingly little benefit from it.     

An experimental investigation of triboelectrification in cohesive and non-cohesive pharmaceutical powders

A detailed experimental investigation has been undertaken of the triboelectrification process of the pharmaceutical excipient alpha-lactose monohydrate and selected drugs. Particle charge studies involved the design and construction of an apparatus to incorporate pneumatic powder feed, triboelectric charging via a cyclone separator and simultaneous powder charge (Q) and mass (M) measurements using a modified Faraday well. Preliminary studies showed the charging of the selected materials to be unaffected by relative humidity up to 84%, due to the very low hygroscopicity of the powders. Experiments using lactose size fractions with brass, steel and cellulose contact charging surfaces conducted at different feeder gas pressures, gave net electronegative specific charge values (Q/M) for the metal surfaces, and electropositive values for cellulose. Specific charge increased linearly with gas pressure for the metals, and non-linearly for cellulose. Samples of micronised lactose and beclomethasone dipropionate (BDP) showed more tendency than unmicronised samples to adhere to the contact surface which resulted in more complex charging processes. A novel system to analyse the charge and mass data in further detail was developed, giving relative Q/M values at unit time intervals. It is proposed that this will overcome the limitations of reliance on the final net specific charge value. Preliminary results indicated differences in the charging mechanism for lactose in contact with the two metal surfaces.     

Assessment of underground cable ratings based on distributed temperature sensing

Numerous power utilities have installed advanced distributed temperature sensing (DTS) systems to measure the temperature of underground cables. This paper presents a general procedure for real-time assessment of underground cable ratings based on DTS. After the identification and location of hot spots on a cable, the cable installation data, load, and DTS-recorded temperature over a period of time are used to estimate soil thermal parameters and assess cable ratings under normal and overloading conditions. In order to accurately estimate soil thermal parameters, a combined technique of the finite-element method and gradient-based optimization is used. The technique was validated in the laboratory and applied to a rating assessment of a 230-kV/500-MVA cable circuit. The assessed continuous and emergency ratings are helpful in improving the operation of this circuit.     

Electric arcing burn hazards

The paper presents recent results in the area of high-power testing aimed at improving the safety of electrical staff working on live equipment. The driver for this work is the American Guide (IEEE 1584) on such exposure hazards, which has the potential for international adoption and, in the authors' opinion, does not provide a suitable methodology for assessing the hazard. A selection of results is presented, obtained in a high-power-system-supplied commercial test laboratory, using the latest charge-coupled device (CCD)-based high-speed video-recording methods. Results are reported for 415-V currents in the range of 1000-70 000 prospective root mean square (rms) amperes and for tests at 5000 V in the range of 1000-27 000 A. The impact of conventional protective devices is included together with some disturbing video results for circuit-breaker-protected systems. The major part of the material in this paper was first presented at the 7th International Conference on Electric Fuses and Their Applications, Jurata, Poland, in 2003.     

Long-term testing and applications of high-stress MV EPR cables

High-stress design 35-kV ethylene propylene rubber (EPR)-insulated cables with 1.14-mm (45-mil) wall reduction have been in service for more than ten years. In the mid 1990s, an extensive cable testing program was initiated to demonstrate that high-stress designs up to 4 kV/mm (101.6 V/mil) exhibit a significant electrical and mechanical safety margin to operate on typical utility network systems. Investigations were also undertaken to demonstrate the suitability of accessories for high-stress designs. This paper will present the results of six-year, long-term wet electrical testing conducted to demonstrate that with proper design, the aging performance of standard wall and high-stress design cables provide satisfactory results and suitable performance for the intended application. Additionally, utility field experience is presented on 35- and 15-kV cables operating at high stress. The experience for these 15-kV medium-voltage EPR cable designs employ the highest recommended stress for cables of this class, as well as taking into account the complete system performance.     

Removal efficiency of subsurface vertical flow constructed wetlands for different organic loads.

Using subsurface vertical flow constructed wetlands (SSVFCWs) with intermittent loading it is possible to fulfil the stringent Austrian effluent standards regarding nitrification. For small plants (less than 500 persons) standards for ammonia nitrogen concentration have to be met at water temperatures higher than 12 degrees C, effluent concentrations and treatment efficiencies for organic matter have to be met the whole year around. According to the Austrian design standards the required surface area for SSVFCWs treating wastewater was 5 m2 per person. Within the first part of an Austrian research project the goal was to optimise, i.e. minimise the surface area requirement of vertical flow beds. Therefore, three SSVFCWs with a surface area of 20 m2 each have been operated in parallel. The organic loads applied were 20, 27 and 40 g COD/m2/d, which corresponds to a specific surface area requirement of 4, 3 and 2 m2 per PE, respectively. The paper compares the effluent concentrations and elimination efficiencies of the three parallel operated beds. It could be shown that a specific area demand of 4 m2 per person is suitable to be included in the revision of the Austrian design standard. Additionally it could be shown that during the warmer seasons (May-October) when the temperature of the effluent is higher than 12 degrees C the specific surface area might be further reduced; even 2 m2 per person has been proven to be adequate.     

The beneficial effects of storage on the quality of wastewater for irrigation: a case study in Sicily.

Although the main function of reservoirs in agriculture is to allow the storage and temporal shifting of large volumes of waters, further benefits emerge from their application in wastewater reuse systems. In fact, as observed in several other studies carried out on such complex natural systems, the storage period, under proper conditions, can lead to a significant improvement of the water quality for irrigation thanks to concurrent physical, chemical and biological processes. In order to investigate the reservoir dynamics, an experimental research was carried out in a farm reservoir (volume of 11,000 m3, maximum depth of 6.3 m and mean depth of about 5 m), receiving treated wastewater and subject to scheduled highly variable input to volume ratios, in order to observe the broadest range of behaviour responses. Specifically, over a monitoring period lasted 4 months, the reservoir was operated as a standard batch reactor in the first and third phases and as a continuous flow reactor in the second one. Based on correlation analysis between the chemical, physical and biological water parameters and operational ones, a new operative index is proposed which integrates the morphological characteristics of the tank and the management ones, and shows a significant correlation with the qualitative characteristics of the stored water.