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Glucose administered to fasted rats caused a marked stimulation in hepatic cholesterogenesis and cholesterol 7 alpha-hydroxylation, and an increase in biliary excretion of cholesterol and total bile acids. The excretion of cholic acid was not incluenced during the first few hr after glucose administration, but was significantly increased after 5 hr. Chenodeoxycholic acid showed a similar change, but the increase was only ca. one tenth of that of cholic acid. The excretion of deoxycholic acid was markedly increased by 1 hr, but gradually decreased thereafter. Pretreatment with neomycin abolished the increase in deoxycholic acid by fasting and glucose administration. Other bile acid components showed no significant change. It thus was presumed that cholesterol endogenously synthesized in the liver was metabolized mainly to cholic acid. In contrast, exogenous cholesterol was metabolized mainly to chenodeoxycholic acid. During the period of the acute enhancement of cholic acid formation from the endogenous cholesterol, biliary excretion of deoxycholic acid was increased. This probably occurred through the depression of 7 alpha-rehydroxylation of deoxycholic acid, or through the enhancement of microbial formation of deoxycholic acid in the lumen, and through the increase of intestinal absorption. 相似文献
74.
Based on B-series theory, the order conditions of the multidimensional ARKN methods are presented for the general multi-frequency and multidimensional oscillatory second-order initial value problems by Wu et al. (2009). These multidimensional ARKN methods exactly integrate the multi-frequency and multidimensional unperturbed oscillators. In this paper, we pay attention to the analysis of the concrete multidimensional ARKN methods for the general multi-frequency oscillatory second-order initial value problems whose right-hand side functions depend on both yand y′ (the class of physical problems which fall within its scope is broader). Numerical experiments are carried out to show that the new multidimensional ARKN methods are more efficient compared with some well-known methods for dealing with the oscillatory problems in the scientific literature. 相似文献
75.
76.
Zhanwu Zhang Kai Way Li Wei Zhang Liang Ma Zhenguo Chen 《International Journal of Industrial Ergonomics》2014
A single arm pushing experiment was conducted in an electronic factory in Yantai, China to assess muscular fatigue using the theoretical models of muscular strength and maximum endurance time (MET) developed by Ma et al. (2009). Seventy seven workers, including 38 males and 39 females, participated in the study. The muscular strength of pushing was measured after the subject pushed a stick, with a force of 2.5 kgf, for 0.5, 1.0, 1.5, 2.0, 2.5, and 3.0 min. Fatigue rate was determined based on a regression approach. In addition to the theoretical model, the MET for such a pushing task was also determined using four empirical models in the literature. The results indicated that females were more resistant to muscular fatigue than males in the pushing task. The results of the muscular strength prediction show that the predictability of the muscular strength model is acceptable. The prediction errors for muscular strength for female subjects were significantly lower than those of the male subjects. The predicted MET using the theoretical model, with a group constant k, was highly correlated with those using the empirical models compared in the current study. 相似文献
77.
The kinetics of the methanation of carbon dioxide was investigated using an alumina supported Ni-La2O2 catalyst in a differential and integral reactor. In the differential reactor the molar ratio of H2 to CO2 was varied from 0.6 to 30. In the integral reactor the rates were measured with up to 90% conversion. Both reactor tests were carried out at temperatures between 513 and 593 K. The experimental results were described by a Langmuir-Hinshelwood type equation. The kinetics can be explained by assuming equilibrium of dissociative carbon dioxide and hydrogen adsorption, and assuming hydrogenation of surface carbon as the rate determining step. 相似文献
78.
Communication is a key success factor of distributed software projects. Poor communication has been identified as a main obstacle to successful collaboration. Global projects are especially endangered by information gaps between collaborating sites. Different communication styles, technical equipment, and missing awareness of each other can cause severe problems. Knowledge about actual and desired channels, paths, and modes of communication is required for improving communication in a globally distributed project. However, many project participants know little about communication and information flow in their projects. In this contribution, we focus on knowledge about communication and information flow. It is acquired by modelling on‐going and desired flows of information, including documented and non‐documented channels of information flow. We analyzed a distributed software project from the information flow perspective. Based on the findings, we developed specific techniques to improve information flow in distributed software development according to the FLOW Method. In a second distributed project, we evaluated one of the techniques. We found the FLOW mapping technique to be suitable for effectively spreading knowledge about communication and information flow in global software projects. 相似文献
79.
This investigation focuses on slow, isothermal, two-phase flow of gas bubble suspensions in Separan solutions, prepared with the help of a sodium borohydride blowing agent at room temperature. The total residence time in these experiments is much smaller than characteristic times for growth or rise of bubbles. The variation of bubble volume fraction across a narrow gap between two planes, is recorded at two locations along the flow direction. This is done with a Cesium gamma-radiation source focused on a region of area.012 cm2 in the flow plane, and a Sodium iodide detector across the channel yielding a resolution of.01 over the range of void fractions investigated from.02 to.08. This measurement allows us to identify conditions under which the two-phase flow may be described by a two fluid model with a uniform bubbly core and a bubble free wall layer. With this two phase flow structure, a relative viscosity equation for the suspension is used to compute an apparent viscosity. Such calculations indicate that the observed reduction in apparent viscosity for the two phase flow may be attributed to a bubbly core which is more shear thinning than the medium. The additional shear thinning factor for the suspension is related to the elasticity of the medium. 相似文献
80.
卫星平台运动会产生恶化像质的像移,像移是影响遥感图像质量的重要因素.针对这种情况,建立了像移和图像参数的关系模型,可通过卫星生成图像的内在特征定量研究卫星成像过程中产生的像移,而不必通过产生像移的卫星平台等因素建立物理模型来研究像移.首先模拟了遥感器在轨成像过程,通过人工制造出影响因素的干扰获得了仿真图像数据,然后定量分析了像移与图像参数之间的相关性,选出了相关性较强且适合建模的图像参数,最后通过对这些图像参数构成的向量的降维得到了反映图像质量的综合参数,并建立了综合参数与像移的关系模型,以通过图像综合参数来计算像移.实验结果表明,这种模型能够很好地反映图像综合指标与像移之间的关系.该研究通过图像参数定量研究像移,为在轨运行卫星的遥感器像移与外景条件下的遥感图像要素的相关建模研究提供了部分技术支持. 相似文献