Operation of quantum-dot semiconductor optical amplifiers under nonuniform current injection

The influence of nonuniform current injection along the active region, on the linear operation of a quantum-dot semiconductor optical amplifier (QD-SOA) is investigated. For this purpose, we have utilized some functions to generate various nonuniform current injection profiles. These profiles have been considered in our numerical calculations, where the rate equation model is employed to construct different characteristics of the QD-SOA. We have found that the gain, as well as the crosstalk, of a QD-SOA is closely associated to the variance of the carrier density along the cavity. Simulation results show that nonuniform current injection can be used as a technique for gain enhancement as well as crosstalk suppression.     

NIR-Laser Triggered Drug Release from Molybdenum Disulfide Nanosheets Modified with Thermosensitive Polymer for Prostate Cancer Treatment

Journal of Inorganic and Organometallic Polymers and Materials - In the present study, the thermosensitive polymers were successfully grown on the surface of molybdenum disulfide nanosheets (MNs)...     

Effect of nonionic side chain length of polycarboxylate-ether-based high-range water-reducing admixture on properties of cementitious systems

Despite the large variations in the behaviors of water-reducing admixtures upon changes in their structures, most previous reports on the cement-admixture compatibility did not provide sufficient information on the structure of the admixture. Hence, the evaluation and generalization of the reports on the cement-admixture compatibility are challenging. In this study, three different polycarboxylate-ether-based water-reducing admixtures with the same free nonionic content, anionic/nonionic molar ratio, and main chain length and different side chain lengths were produced. The compatibility of these admixtures with a CEM I 42.5R-type cement was investigated. In addition, an analysis of variance was performed on the experiment results to evaluate the contributions of the admixture type, admixture/cement ratio, and elapsing time to the Marsh funnel flow time, mini-slump, slump flow, and compressive strength. The water-reducing admixtures having long or short side chains reduced the initial flow characteristics of the cementitious systems. However, the admixture having the shortest side chain was better with regard to flow retention. The side chain length of the admixture did not have significant effects on the compressive strength and water absorption capacity of the mortar mixtures and mini-slump performances of the cement paste mixtures. Regarding the behaviors of the admixtures in the cementitious systems, an optimal admixture side chain molecular weight is proposed.     

Optimizing PSMA Radioligand Therapy for Patients with Metastatic Castration-Resistant Prostate Cancer. A Systematic Review and Meta-Analysis

The aim of the review was to evaluate patient and treatment characteristics for patients with metastatic castration-resistant prostate cancer (mCRPC) treated with PSMA radioligand therapy (PRLT) associated with above-average outcome. The systematic review and meta-analysis followed recommendations by the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA). We searched for publications in PubMed, Embase, and ClinicalTrials.gov up to 31 September 2020. Thirty-six publications and four duplicates reported 2346 patients. Nearly two-thirds of the patients had bone metastases. Median overall survival (OS) was 16 months. Asymptomatic patients and patients with only lymph node metastases lived longer than symptomatic patients and patients with more extensive metastases. Patients treated with an intensified schedule of ¹⁷⁷Lu PRLT lived longer than those treated with a conventional schedule. Half of the patients obtained a PSA decline ≥ 50% and these patients lived longer than those with less PSA decline. Approximately 10% of the patients developed hematologic toxicity with anemia grade 3 as the most severe adverse effect. Characteristics for patients, cancer, restaging, and PRLT predict above average overall survival following treatment with PRLT.     

Security anomaly detection in software‐defined networking based on a prediction technique

Nowadays, software‐defined networking (SDN) is regarded as the best solution for the centralized handling and monitoring of large networks. However, it should be noted that SDN architecture suffers from the same security issues, which are the case with common networks. As a case in point, one of the shortcomings of SDNs is related to its high vulnerability to distributed denial of service (DDoS) attacks and other similar ones. Indeed, anomaly detection systems have been considered to deal with these attacks. The challenges are related to designing these systems including gathering data, extracting effective features, and selecting the best model for anomaly detection. In this paper, a novel combined approach is proposed; this method uses NetFlow protocol for gathering information and generating dataset, information gain ratio (IGR), in order to select the effective and relevant features and ensemble learning scheme (Stacking) for developing a structure with desirable performance and efficiency for detecting anomaly in SDN environment. The results obtained from the experiments revealed that the proposed method performs better than other methods in terms of enhancing accuracy (AC) and detection rate (DR) and reducing classification error (CE) and false alarm rate (FAR). The AC, DR, CE, and FAR of the proposed model were measured as 99.92%, 99.83%, 0.08%, and 0.03%, respectively. Furthermore, the proposed method prevents the occurrence of excessive overload on the controller and OpenFlow.     

A novel super compact half‐mode substrate‐integrated waveguide filter using modified complementary split‐ring resonator

A novel super compact filter based on half‐mode substrate‐integrated waveguide (HMSIW) technology loaded by the modified complementary split‐ring resonator (MCSRR) is proposed. The working principle of the proposed filter is based on the evanescent‐mode propagation technique. According to this technique, by loading the complementary split‐ring resonator (CSRR) on the metal surface of the substrate‐integrated waveguide (SIW) structure, an additional passband below the SIW cutoff frequency can be obtained. In order to miniaturize the physical size of the conventional CSRR, a new method is introduced. In the proposed MCSRR unit‐cell, the meander slots are carved inside all of the interior space of the ring. Accordingly, the length of the slot is increased which leads to an increase in the inductor and capacitor of the proposed structure without occupying the extra space. Therefore, the electrical size of the proposed MCSRR unit‐cell is reduced. Consequently, the resonance frequency of the proposed MCSRR unit‐cell is decreased compared to the conventional CSRR with the same sizes. Namely, the lower resonance frequencies can be achieved by using this technique without increasing the size of the unit‐cell. In order to confirm the miniaturization technique, two HMSIW filters loaded by the proposed MCSRR unit‐cell are designed, fabricated, and experimental verifications are provided. The results show that a miniaturization about 67% is achieved.     

Compact metamaterial unit‐cell based on stepped‐impedance resonator technique and its application to miniaturize substrate integrated waveguide filter and diplexer

In this article, a new miniaturized metamaterial unit‐cell using stepped‐impedance resonator technique is proposed. The proposed unit‐cell is used to miniaturize the physical size of the conventional complementary split‐ring resonators (CSRRs). In the proposed unit‐cell which is called complementary G‐shaped resonator (CGR), the slot line in the conventional circular CSRR is replaced with the stepped‐impedance slot line. As well as, by carving two trapezoidal shapes inside the inner ring, the resonance frequency of the proposed CGR unit‐cell has been more decreased. Compared to the conventional circular CSRR structure, the electrical size of the proposed CGR is decreased and miniaturization is occurred. To investigate the performance of the proposed CGR unit‐cell in the size reduction, two substrate integrated waveguide filters and a diplexer are designed. To validate the proposed miniaturization technique, the designed filters and diplexer loaded by the CGR unit‐cell are fabricated and measured. The measured results are in a good agreement with the simulated ones. The results shows that, a miniaturization factor about 0.69 is achieved.     

Effects of coating layer and release medium on release profile from coated capsules with Eudragit FS 30D: an in vitro and in vivo study

The aim of the present research was to evaluate the impact of coating layers on release profile from enteric coated dosage forms. Capsules were coated with Eudragit FS 30D using dipping method. The drug profile was evaluated in both phosphate buffer and Hank’s solutions. Utilization X-ray imaging, gastrointestinal transmission of enteric coated capsules was traced in rats. According to the results, no release of the drug was found at pH 1.2, and the extent of release drug in pH 6.8 medium was decreased by adding the coating layers. The results indicated single-layer coated capsules in phosphate buffer were significantly higher than that in Hank’s solution. However, no significant difference was observed from capsules with three coating layers in two different dissolution media. X-ray imaging showed that enteric coated capsules were intact in the stomach and in the small intestine, while disintegrated in the colon.     

The cost-effective fault detection and fault location approach for communication channels in NoC

In the current paper, we propose a new online search, fault detection, and fault location approach for short faults in network on chip communication channels. The approach proposed consists of a built-in self-test as well as a packet/flit comparings module embedded in the network adapter and a router, respectively. The approach is mainly characterized by the fact that, firstly, the diagnosis and location processes are simultaneously carried out after which the test time is minimized. Secondly, the approach updates the NoC routing tables far less costly in a parallel fashion. Thirdly, insignificant hardware is added to the system. The high scalability in the approach, in addition, leads to 100% test coverage, 71.4% capability of detecting faulty channels, and 100% detected faults location in one round (two phases). The simulation results show that the approach hardware is optimized compared with the previous methodologies.     

Characterisation of melt spun Ni-Ti shape memory Ribbons’ microstructure

NiTi alloys are the most technologically important medical Shape Memory Alloys in a wide range of applications used in Orthopaedics, Neurology, Cardiology and interventional Radiology as guide-wires, self-expandable stents, stent grafts, inferior vena cava filters and clinical instruments. This paper discusses the use of rapid solidification by the melt spinning method for the preparation of thin NiTi ribbons for medical uses. Generally, the application of rapid solidification via melt-spinning can change the microstructure drastically, which improves ductility and shape memory characteristics and leads to samples with small dimensions. As the increase in the wheel speed led to a reduced ribbon thickness, the cooling rate increased and, therefore, the martensitic substructure became finer. Furthermore, no transition from the crystalline phase to the amorphous phase was obtained by increasing the cooling rate, even at a wheel speed of 30 m/s. Specimens for our metallographic investigation were cut from the longitudinal cross sections of melt-spun ribbons. Conventional TEM studies were carried out with an acceleration voltage of 120 kV. Additionally, the chemical composition of the samples was examined with a TEM equipped with an EDX analyser. The crystallographic structure was determined using Bragg-Brentano x-ray diffraction with Cu-K?? radiation at room temperature.