The regulation of an age-structured population by a fatal disease

A model describing the effect of a fatal disease on an age-structured population which would otherwise grow is presented and analysed. If the disease is capable of regulating host numbers, there is an endemic steady age distribution (SAD), for which an analytic expression is obtained under some simplifying assumptions. The ability of the disease to regulate the population depends on a parameter R(alpha), which is defined in terms of the given age-dependent birth and death rates, and where alpha is the age-dependent disease-induced death rate. If R(alpha) < 1 the endemic SAD is attained, while R(alpha) > 1 means the disease cannot control the population's size. The number R(0) is the expected number of offspring produced by each individual in the absence of the disease; for a growing population we require R(0) > 1. A stability analysis is also performed and it is conjectured that the endemic SAD is locally asymptotically stable whenever it is attained. This is demonstrated explicitly for a very simple example where all rates are taken as constant.     

A 1550-nm millimeter-wave photodetector with a bandwidth-efficiencyproduct of 2.4 THz

The monolithic integration of an optical preamplifier and a waveguide p-i-n photodiode has resulted in a 1550-nm photodetector having an external quantum efficiency of 72 (a responsivity of 89 A/W) and an electrical bandwidth of 33.5 GHz. These figures combine to give a bandwidth efficiency product of 2.4 THz, which is approximately one hundred times higher than for any other type of millimeter-wave photodetector published to date. In addition, the preamplifier performance is supplemented by wide optical bandwidth (60 nm), low polarization sensitivity (1 dB), near traveling wave amplification (1-dB maximum gain ripple), and high saturated output power (+11 dBm). The principal advance over work reported earlier is the traveling wave operation of the monolithic optical preamplifier     

Replication terminator protein-based replication fork-arrest systems in various Bacillus species

The replication terminator protein (RTP) of Bacillus subtilis interacts with its cognate DNA terminators to cause replication fork arrest, thereby ensuring that the forks approaching one another at the conclusion of a round of replication meet within a restricted terminus region. A similar situation exists in Escherichia coli, but it appears that the fork-arrest systems in these two organisms have evolved independently of one another. In the present work, RTP homologs in four species closely related to B. subtilis (B. atrophaeus, B. amyloliquefaciens, B. mojavensis, and B. vallismortis) have been identified and characterized. An RTP homolog could not be identified in another closely related species, B. licheniformis. The nucleotide and amino acid changes from B. subtilis among the four homologs are consistent with the recently established phylogenetic tree for these species. The GC contents of the rtp genes raise the possibility that these organisms arose within this branch of the tree by horizontal transfer into a common ancestor after their divergence from B. licheniformis. Only 5 amino acid residue positions were changed among the four homologs, despite an up to 17.2% change in the nucleotide sequence, a finding that highlights the importance of the precise folded structure to the functioning of RTP. The absence of any significant change in the proposed DNA-binding region of RTP emphasizes the importance of its high affinity for the DNA terminator in its functioning. By coincidence, the single change (E30K) found in the B. mojavensis RTP corresponds exactly to that purposefully introduced by others into B. subtilis RTP to implicate a crucial role for E30 in the fork-arrest mechanism. The natural occurrence of this variant is difficult to reconcile with such an implication, and it was shown directly that RTP.E30K functions normally in fork arrest in B. subtilis in vivo. Additional DNA terminators were identified in the new RTP homolog-containing strains, allowing the definition of a Bacillus terminator consensus and identification of two more terminators in the B. subtilis 168 genome sequence to bring the total to nine.     

p-i-nf.e.t. hybrid optical receiver for 1.1?1.6 ?m optical communication systems

The fabrication of low capacitance v.p.e. InGaAs/InP p-i-n photodiodes having a high responsivity up to 1.6 ?m wavelength is described. The receiver sensitivities of the p-i-n f.e.t. hybrid receiver for a 280 Mbit/s system, measured at 1.3?m and 1.5 ?m are ?38.9 dBm and ?39.4 dBm,respectively.     

Planning Resettlement After Disasters

Problem, research strategy, and findings: The number of people displaced either temporarily or permanently from natural disasters has been increasing at an unprecedented rate. As a result, there is a growing need for a systematic framework of resettlement planning after disasters, to either rebuild in place (in situ) or to relocate, and whether to do so independently or collaboratively with their neighbors. To gain an in-depth understanding of how resettlement is advanced, I focus on a region in Chuetsu, Japan, supplemented with cases in New Orleans (LA) and Tohoku, Japan. Results suggest that resettlement decisions, processes, and outcomes reflect both larger socioeconomic trends and interactions between governments, communities, and households. Although the governments' speed of resettlement planning and implementation initially set the pace, informal communication within communities most influenced decision making. In addition, inherent community dynamics, especially styles of communication, directly influenced resettlement decisions and outcomes.

Takeaway for practice: Although every disaster is unique in its context, communities are the key players in determining resettlement outcomes. Key points of consideration include: a) resettlement decision processes vary based on the inherent characteristics of communities; b) government officials often emphasize speed, even though it undermines overall quality of rebuilding; c) reestablishing livelihoods of equal or greater satisfaction to that before the disaster is important; and d) local communities are often capable of identifying and acting for their needs, regardless of governmental intentions. Planners need to support the establishment of a system in which communities are empowered by governments to make the most suitable decisions for sustainable livelihood recovery.     

Regulation of Photochemical Energy Transfer Accompanied by Structural Changes in Thylakoid Membranes of Heat-Stressed Wheat

Photosystems of higher plants alleviate heat-induced damage in the presence of light under moderate stressed conditions; however, in the absence of light (i.e., in the dark), the same plants are damaged more easily. (Yamauchi and Kimura, 2011) We demonstrate that regulating photochemical energy transfer in heat-treated wheat at 40 °C with light contributed to heat tolerance of the photosystem. Chlorophyll fluorescence analysis using heat-stressed wheat seedlings in light showed increased non-photochemical quenching (NPQ) of chlorophyll fluorescence, which was due to thermal dissipation that was increased by state 1 to state 2 transition. Transmission electron microscopy revealed structural changes in thylakoid membranes, including unstacking of grana regions under heat stress in light. It was accompanied by the phosphorylation of thylakoid proteins such as D1 and D2 proteins and the light harvesting complex II proteins Lhcb1 and Lhcb2. These results suggest that heat stress at 40 °C in light induces state 1 to state 2 transition for the preferential excitation of photosystem I (PSI) by phosphorylating thylakoid proteins more strongly. Structural changes of thylakoid membrane also assist the remodeling of photosystems and regulation of energy distribution by transition toward state 2 probably contributes to plastoquione oxidation; thus, light-driven electrons flowing through PSI play a protective role against PSII damage under heat stress.     

Presence of lactoferrin in a bovine skim milk fraction with acid phosphatase activity

The aim of this study was to determine the principal active molecules in the acid phosphatase (AcP) fraction of skim milk origin using immunostaining and AcP staining. The AcP fraction was separated from skim milk at 0.38 m NaCl using carboxymethyl cellulose chromatography at pH 5.2. The molecular mass of the active molecule in AcP fraction was estimated to be 80 kDa by immunostaining and AcP staining. The 80 kDa protein was analyzed by a protein sequencer, using the automated Edman degradation method; the first thirteen N-terminal amino acid sequence obtained were shown to be APRKNVRWXTIXQ. For that amino acid sequence, there was 84% (11/13 residues) homology with the amino acid sequence of bovine lactoferrin (LF). The AcP fraction and commercial LF showed a similar AcP activity profile, having an optimum pH of 4.5 and temperature of 60 °C. Thus, the AcP fraction from bovine skim milk was isolated and the principal active molecule present was tentatively identified as LF.     

Postnatal uterine development in Inverdale ewe lambs

Postnatal development of the uterus involves, particularly, development of uterine glands. Studies with ovariectomized ewe lambs demonstrated a role for ovaries in uterine growth and endometrial gland development between postnatal days (PNDs) 14 and 56. The uterotrophic ovarian factor(s) is presumably derived from the large numbers of growing follicles in the neonatal ovary present after PND 14. The Inverdale gene mutation (FecXI) results in an increased ovulation rate in heterozygous ewes; however, homozygous ewes (II) are infertile and have 'streak' ovaries that lack normal developing of preantral and antral follicles. Uteri were obtained on PND 56 to determine whether postnatal uterine development differs between wild-type (++) and II Inverdale ewes. When compared with wild-type ewes, uterine weight of II ewes was 52% lower, and uterine horn length tended to be shorter, resulting in a 68% reduction in uterine weight:length ratio in II ewes. Histomorphometrical analyses determined that endometria and myometria of II ewes were thinner and intercaruncular endometrium contained 38% fewer endometrial glands. Concentrations of estradiol in the neonatal ewes were low and not different between ++ and II ewes, but II ewes had lower concentrations of testosterone and inhibin-alpha between PNDs 14 and 56. Receptors for androgen and activin were detected in the neonatal uteri of both ++ and II ewes. These results support the concept that developing preantral and/or antral follicles of the ovary secrete uterotrophic factors, perhaps testosterone or inhibin-alpha, that acts in an endocrine manner to stimulate uterine growth and endometrial gland development in the neonatal ewes.