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81.
Interacting in the Internet, users should be empowered to use only those subsets of their personal attributes, called partial identities, which are appropriate for the actual situation and context. Refraining from acting under few and easily linkable partial identities is a prerequisite for trustworthy privacy. Traditionally user-controlled identity management systems primarily support individuals interacting with organisations, but mainly ignore special needs which arise if individuals interact with each other. To support online communities those systems have to change. From TU Dresden: Prof. Dr. Andreas Pfitzmann, head of the privacy and security group, and the research assistants Dipl.-Inform. Katrin Borcea-Pfitzmann, Dipl. Medien-inf. Katja Liesebach and Dipl.-Inform. Sandra Steinbrecher. From ULD, Kiel: Dipl.-Inform. Marit Hansen, head of PET division. Research Focus: Privacy in Identity Management and Application Design This work was funded in part by the PRIME project which receives research funding from the European Union’s Sixth Framework Programme and the Swiss Federal Office for Education and Science.  相似文献   
82.
Uncertainties in the organization, external environment and from single projects may hamper project portfolio performance unless managed properly. This paper introduces a framework on uncertainties and their management in project portfolios and pursues increased understanding on how managers can take uncertainty into account better. We explore uncertainties, how managers frame them as opportunities or threats, and the actual practice of managing them across ten R&D project portfolios. The framework on project portfolio uncertainties and their management is further refined based on the empirical results. As key contributions, we show evidence on the balanced existence of three types of uncertainties, the threat bias in their framing, and the dominance of rational, opportunity driven mechanisms of control in uncertainty management. We discuss the context-dependent practice of project portfolio management and the need to complement rational mechanisms with structural and cultural, for project portfolio management to become a dynamic capability.  相似文献   
83.
Scots pine (Pinus sylvestris L.) wood was surface densified in its radial direction in an open press with one heated plate to obtain a higher density on the wood surface whilst retaining the overall thickness of the sample. This study investigated the effect of temperature (100, 150 and 200 °C) and press closing speed (5, 10 and 30 mm/min, giving closing times of 60, 30 and 10 s, respectively) on the micromorphology of the cell-wall, as well as changes occurring during set-recovery of the densified wood. The micromorphology was analysed using scanning electron microscopy (SEM) combined with a sample preparation technique based on ultraviolet-excimer laser ablation. Furthermore, the density profiles of the samples were measured. Low press temperature (100 °C) and short closing time (10 s) resulted in more deformation through the whole thickness, whilst increasing the temperature (150 and 200 °C) and prolonging the closing time (30 and 60 s) enabled more targeted deformation closer to the heated plate. The deformation occurred in the earlywood regions as curling and twisting of the radial cell-walls, however, no apparent cell-wall disruption or internal fracture was observed, even at low temperatures and fast press closing speed, nor after soaking and drying of the samples. In the SEM-analysis after soaking and drying, it was noticed that the cells did not completely recover their original form. Thus, part of the deformation was considered permanent perhaps due to viscoelastic flow and plastic deformation of the cell-wall components.  相似文献   
84.
Mesenchymal stromal cells (MSCs) are promising candidates in regenerative cell‐therapies. However, optimizing their number and route of delivery remains a critical issue, which can be addressed by monitoring the MSCs’ bio‐distribution in vivo using super‐paramagnetic iron‐oxide nanoparticles (SPIONs). In this study, amino‐polyvinyl alcohol coated (A‐PVA) SPIONs are introduced for cell‐labeling and visualization by magnetic resonance imaging (MRI) of human MSCs. Size and surface charge of A‐PVA‐SPIONs differ depending on their solvent. Under MSC‐labeling conditions, A‐PVA‐SPIONs have a hydrodynamic diameter of 42 ± 2 nm and a negative Zeta potential of 25 ± 5 mV, which enable efficient internalization by MSCs without the need to use transfection agents. Transmission X‐ray microscopy localizes A‐PVA‐SPIONs in intracellular vesicles and as cytosolic single particles. After identifying non‐interfering cell‐assays and determining the delivered and cellular dose, in addition to the administered dose, A‐PVA‐SPIONs are found to be non‐toxic to MSCs and non‐destructive towards their multi‐lineage differentiation potential. Surprisingly, MSC migration is increased. In MRI, A‐PVA‐SPION‐labeled MSCs are successfully visualized in vitro and in vivo. In conclusion, A‐PVA‐SPIONs have no unfavorable influences on MSCs, although it becomes evident how sensitive their functional behavior is towards SPION‐labeling. And A‐PVA‐SPIONs allow MSC‐monitoring in vivo.  相似文献   
85.
The neutron capture detector (NCD) is introduced as a novel detection scheme for thermal and epithermal neutrons that could provide large-area neutron counters by using common detector materials and proven technologies. The NCD is based on the fact that neutron captures are usually followed by prompt gamma cascades, where the sum energy of the gammas equals to the total excitation energy of typically 6-9 MeV. This large sum energy is measured in a calorimetric approach and taken as the signature of a neutron capture event. An NCD consists of a neutron converter, comprising of constituents with large elemental neutron capture cross-section like cadmium or gadolinium, which is embedded in common scintillator material. The scintillator must be large and dense enough to absorb with reasonable probability a portion of the sum energy that exceeds the energy of gammas emitted by common (natural, medical, industrial) radiation sources. An energy window, advantageously complemented with a multiplicity filter, then discriminates neutron capture signals against background. The paper presents experimental results obtained at the cold-neutron beam of the BER II research reactor, Helmholtz-Zentrum Berlin, and at other neutron sources with a prototype NCD, consisting of four BGO crystals with embedded cadmium sheets, and with a benchmark configuration consisting of two separate NaI(Tl) detectors. The detector responses are in excellent agreement with predictions of a simulation model developed for optimizing NCD configurations. NCDs could be deployed as neutron detectors in radiation portal monitors (RPMs). Advanced modular scintillation detector systems could even combine neutron and gamma sensitivity with excellent background suppression at minimum overall expense.  相似文献   
86.
Microbially Induced Carbonate Precipitation is proposed as an environmentally friendly method to protect decayed ornamental stone and introduced in the field of preservation of Cultural Heritage. Recent conservation studies performed under laboratory conditions on non-sterile calcarenite stones have successfully reported on the application of a suitable nutritional solution, inoculated and non-inoculated with Myxococcus xanthus, as a bioconsolidation treatment. Furthermore, this procedure has been applied in situ, very recently, to selected historical buildings in Granada, Spain. For the first time, we evaluate the efficiency and risks of the in situ application of the above mentioned treatments onto two historical buildings in Granada. The evaluation consists of a detailed investigation of the micro-biota actively growing during the seven days of the treatments - short-term monitoring and of that remaining on the stones after six and twelve months of the application - long-term monitoring. A molecular strategy, including DNA extraction, PCR amplification of 16S rRNA sequences, construction of clone libraries and fingerprinting by DGGE (Denaturing Gradient Gel Electrophoresis) analysis followed by sequencing was used to gain insight into the microbial diversity present on the differentially treated stones. The monitoring of M. xanthus was performed by PCR using species-specific primers. Similar dynamics were triggered on both buildings by the application of the nutritional solution (inoculated or non-inoculated). 16S rDNA sequencing revealed the dominant occurrence of members belonging to the Firmicutes and Proteobacteria during the seven days of the treatment, whereas after one year the order Bacillales of the phylum Firmicutes was the predominantly detected microorganisms. M. xanthus could be detected only during the seven days of the treatment. The treatments seem to activate no dangerous microorganisms and furthermore, to select the remainder of a homogeneous group of carbonatogenic bacteria on the stones after a long period of time.  相似文献   
87.
Liquid‐feed flame spray pyrolysis provides easily dispersed, unaggregated nanopowders with average particle sizes of 20–70 nm depending on the processing conditions. Their chemical compositions can be controlled to ppm levels via control of the initial precursor solution. In this paper, Y3Al5O12 composition nanopowders are produced that are atomically mixed but offer a hexagonal crystal structure rather than a YAG structure. Y2O3 and δ‐Al2O3 nanopowders are also produced and mixed to evaluate reactive sintering. It is shown that nanopowder/polymer mixtures permit the extrusion of tubes that retain their shape on debindering and sintering to ≥95% theoretical density. More importantly, the sintering behavior of hex‐Y3Al5O12 is compared with that of tubes formed using 3:5 Y2O3:δ‐Al2O3 mixtures to test the so‐called bottom‐up paradigm, which suggests that mixing on the finest length scales should provide optimal control of sintering rates, final densities, and grain sizes. Instead, it is found that reactive sintering is faster and offers better control of final grain sizes. Dense sintered tubes are translucent, and dimensional uniformity is maintained from extrusion through sintering.  相似文献   
88.
A new system for computer-aided corrective surgery of the jaws has been developed and introduced clinically. It combines three-dimensional (3-D) surgical planning with conventional dental occlusion planning. The developed software allows simulating the surgical correction on virtual 3-D models of the facial skeleton generated from computed tomography (CT) scans. Surgery planning and simulation include dynamic cephalometry, semi-automatic mirroring, interactive cutting of bone and segment repositioning. By coupling the software with a tracking system and with the help of a special registration procedure, we are able to acquire dental occlusion plans from plaster model mounts. Upon completion of the surgical plan, the setup is used to manufacture positioning splints for intraoperative guidance. The system provides further intraoperative assistance with the help of a display showing jaw positions and 3-D positioning guides updated in real time during the surgical procedure. The proposed approach offers the advantages of 3-D visualization and tracking technology without sacrificing long-proven cast-based techniques for dental occlusion evaluation. The system has been applied on one patient. Throughout this procedure, we have experienced improved assessment of pathology, increased precision, and augmented control.  相似文献   
89.
We argue that practical endeavours towards mobilising and recreating knowledge is an integral part of value increasing activities, and expose how this dependency can be utilised in ameliorating practice. This bridging of knowledge and value creation constitutes organisational activities as knowing. The paper exposes the efforts of Telenor, a large telecom firm, to create an enduring agenda for non‐financial issues in management. We expose the development process and initial use of their new Integrated Management Business Model. This involves identifying financial and non‐financial drivers of future performance within and across several business units, as well as negotiating on appropriate indicators of both status and change. The paper pays special attention to the iterative approach to development in order to highlight a shift from an attempt to enable knowledge in autonomous processes secluded from everyday activities, towards an understanding of knowledge and knowing as intrinsic to the value creating activities performed. By entering the issue of intangibles through the knowing activity perspective, it was evident that the purpose of the management system was not to determine the status of intangibles in the corporation, it was to improve it.  相似文献   
90.
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