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91.
Dr. Travis Coyle Dr. Liang Wu Dr. Aleksandra W. Debowski Prof. Gideon J. Davies Dr. Keith A. Stubbs 《Chembiochem : a European journal of chemical biology》2019,20(11):1365-1368
The sugar fucose plays a myriad of roles in biological recognition. Enzymes hydrolyzing fucose from glycoconjugates, α-l -fucosidases, are important targets for inhibitor and probe development. Here we describe the synthesis and evaluation of novel α-l -fucosidase inhibitors, with X-ray crystallographic analysis using an α-l -fucosidase from Bacteroides thetaiotamicron helping to lay a foundation for future development of inhibitors for this important enzyme class. 相似文献
92.
93.
Korolev Vadim V. Bean Jonathan J. Nevolin Yurii M. Kucherinenko Yaroslav V. McKenna Keith P. Protsenko Pavel V. 《Metallurgical and Materials Transactions A》2022,53(2):449-459
Metallurgical and Materials Transactions A - The misorientation of 515 grain boundaries has been determined using electron backscatter diffraction data from an 18 μm thick copper foil with... 相似文献
94.
A process has been developed for the synthesis of a new photochromic alkylene sulfide derivative. The process involves the synthesis of an alkylene sulfide with terminal free amino groups and a novel unsymmetrical photochromic diarylperfluorocyclopentene containing an aldehyde group, which coupled together to produce the corresponding Schiff base. The structures of the products were confirmed by a range of spectroscopic techniques. 相似文献
95.
An integrative conflict analysis approach, incorporating an Analytic Hierarchy Process (AHP) based preference ranking method into the Graph Model for Conflict Resolution (GMCR), is employed to investigate the Canadian west coast port congestion dispute. The Canadian west coast has historically been an important gateway connecting North America to Asia thanks to its specific geographical and strategic location. Despite successful operations and maintenance of the port facilities to handle international trade during the past few decades, the west coast is now facing increasing congestion problems, resulting in significant delays in transporting goods from the west coast to other parts of Canada and the USA. The strategic analyses carried out in this research suggest potential resolutions in which Canada would expand port facilities at various locations, encouraging traders to continue choosing the Canadian west coast as one of their trade gateways to North America. 相似文献
96.
ARMA models provide a parsimonious and flexible mechanism for modeling the evolution of a time series. Some useful measures of these models (e.g., the autocorrelation function or the spectral density function) are tedious to compute by hand. This paper uses a computer algebra system, not simulation, to calculate measures of interest associated with ARMA models. 相似文献
97.
具有内部同步、2A开关的36V LED驱动器LT3922,是一款紧凑、通用的LED驱动器。 相似文献
98.
Keith Schofield 《Combustion and Flame》2012,159(5):1987-1996
Quantitative deposition studies are reported involving flame gases containing traces of sodium and chlorine. Comparisons with previously published and unpublished data involving Na2SO4 and Na2CO3 deposition indicate a similar behavior and a generic type mechanism. A wide series of propane and hydrogen flames of varying equivalence ratio have been examined that contain sodium on a part per million by volume scale (ppmv) and chlorine either as a similar trace amount or in excess. An important aspect is that deposition is efficient and the product does not directly correlate to the gas-phase metal speciation. Whether sodium is present as gaseous NaCl, NaOH or Na in a flame is irrelevant to the composition of the deposit. Rates are controlled by the total amount of sodium reaching the surface. Once there, the flame becomes solely a provenience of preferred ingredients. Below 850 K, formation rates of NaCl, Na2CO3 or Na2SO4 are the same, and for Na/Cl containing flames the ranking is NaCl > Na2CO3 > NaOH as predicted by thermodynamics. Rates are first-order in alkali and zero-order for chlorine concentrations. They are independent of equivalence ratio, flame temperature, flow velocity, or temperature gradient across the surface boundary layer. Compositional analyses of deposits indicate that below 850 K, where NaCl vaporization is negligible, a several fold excess of chlorine over sodium is required to produce the theoretically predicted 100% deposit of NaCl. The data suggest slight kinetic constraints relating to the chlorine concentrations, which might imply conversions of transient hydroxide or carbonate. Deposition of NaCl continues to higher temperatures but rapidly becomes short-lived due to vaporization. Deposition processes are seen as a steady state balance between a perpetual influx and egress of materials at all temperatures. In this regard, steel corrosion by NaCl is reported above its ‘dew point’ with the formation of Na2CrO4. 相似文献
99.
Aguayo David; Herman Keith; Ojeda Lizette; Flores Lisa Y. 《Canadian Metallurgical Quarterly》2011,4(2):79
In hopes of promoting college success among Mexican Americans, researchers have identified factors related to their academic performance. A gap in the literature exists between the interactive role of acculturation, enculturation, and generation status in predicting college self-efficacy and college performance (grade-point average, or GPA). To fill this void, this study investigated the relation of demographic variables (e.g., age, gender, socioeconomic status) and cultural variables (e.g., acculturation, enculturation, generation status) on academic outcomes (e.g., college self-efficacy, college performance) among 408 Mexican-American college students. Results of a series of hierarchical regression analyses indicated socioeconomic status, generation status, enculturation, and acculturation had significant positive effects on college self-efficacy; socioeconomic status and the interaction of higher enculturation and first-generation status were positively and significantly related to GPA. Post-hoc analyses indicated college self-efficacy predicted college performance for students who were second generation and beyond. Implications for research and practice are discussed. (PsycINFO Database Record (c) 2011 APA, all rights reserved) 相似文献
100.
This paper examines the role of public art in urban redevelopment, focusing on the reconstruction of Coventry (UK) in the post-war years. Overseen by the city's Chief Architect, Donald Gibson, this redevelopment has often been described as resulting in a placeless and artless urban landscape indistinguishable from other redeveloped city centres in post-war Britain. To the contrary, here it is suggested that public art was an important feature of Coventry's new urban landscape, with the attempt to create a new civic identity manifest in a series of highly symbolic and distinctive public artworks. Analysing both the official symbolism of these artworks and their reception in the public sphere, it is concluded that, although just one aspect of the urban landscape, the production and consumption of public art encapsulated the tensions that existed between different visions of the city. 相似文献