Propionates and Acetates of Chiral Secondary Alcohols: Novel Sex Pheromone Components Produced by a Lichen Moth Barsine expressa (Arctiidae: Lithosiinae)

Females of a lichen moth, Barsine expressa (Arctiidae, Lithosiinae), which inhabit Iriomote Island in Japan, were captured by a black-light trap, and the pheromone gland extract was analyzed by gas chromatography (GC) with an electroantennographic (EAG) detector, and by GC coupled with mass spectrometry. The females produced several EAG-active esters, and the mass spectrum of a major component indicated the mixture consists of propionates derived from C₁₇-saturated secondary alcohols, which were inseparable on the capillary GC column. In addition to these main components, the pheromone glands included two acetate derivatives of C₁₇ alcohols, and other propionates of C₁₆ and C₁₅ alcohols. The crude extract was treated with K₂CO₃, and a 1:1 mixture of C₁₇ alcohols with a C₆- or C₇-chain moiety was obtained. The two alcohols were uniformly converted into monodeuterated n-heptadecane by mesylation and succeeding LiAlD₄ reduction. This result revealed a straight-chain structure of the C₁₇ alcohols with the acyl groups located at the 7- or 8-position. Field tests on Iriomote Island showed that the synthetic esters were behaviorally active. A 1:1 mixture of racemic 7-propioxyheptadecane and 8-propioxyheptadecane, which were prepared from the secondary alcohols synthesized by a Grignard coupling reaction, attracted male moths. Furthermore, propionates of the alcohols synthesized enantioselectively by using a hydrolytic kinetic resolution with Jacobsen’s catalyst were evaluated. Only the traps baited with a mixture of the two esters with the same S-configuration significantly attracted B. expressa males. In the Tokyo area, the propionate mixture attracted a closely related species, Barsine aberrans aberrans.     

Birefringent imaging spectrometer

A Fourier-transform imaging spectrometer, believed to be novel, based on the Savart polariscope is presented. There is no slit in this instrument, which means that it has a high throughput. The principle and the system configuration are described. Several preliminary experimental results are shown.     

Janus Kinase Inhibitors Ameliorated Gastrointestinal Amyloidosis and Hypoalbuminemia in Persistent Dermatitis Mouse Model

Malnutrition is not only regarded as a complication of rheumatoid arthritis and inflammatory bowel disease but also that of inflammatory skin disease; however, the mechanisms and efficacy of its treatment have not been elucidated. Using a mouse model of dermatitis, we investigated the pathophysiology of malnutrition in inflammatory skin conditions and efficacy of its treatment. We employed spontaneous skin inflammation mice models overexpressing human caspase-1 in the epidermal keratinocytes. Body weight, nutrition level, and α1-antitrypsin fecal concentration were measured. The gastrointestinal tract was histologically and functionally investigated. Fluorescein isothiocyanate (FITC)-dextran was forcibly fed on an empty stomach, and plasma FITC-dextran was measured. The treatment efficacy of antibodies against tumor necrosis factor-α (TNF-α) and interleukin (IL)-α/β as well as Janus kinase (JAK) inhibitors was investigated. Compared with wild-type littermates, the inflammatory skin mice models showed a lowered body weight, reduction of serum albumin level, amyloid deposition in the stomach, small intestine, and large intestine, and increased α1-antitrypsin fecal concentration. However, the plasma FITC-dextran was unchanged between the dermatitis models and wild-type littermates. The over-produced serum amyloid A1 in the liver was detected in the plasma in the dermatitis model. Antibodies against TNF-α and IL-α/β showed partial effects on amyloid deposition; however, JAK inhibitors improved gastrointestinal amyloidosis with the improvement of skin symptoms. Chronic dermatitis is closely related to secondary amyloidosis in the gastrointestinal tract, resulting in hypoalbuminemia. Therefore, active control of skin inflammation is essential for preventing gastrointestinal complications.     

Synthesis of Anatase-Type TiO2 Nanocrystallites Via a Redox Route

Anatase nanocrystallites showing high surface area (∼62 m²/g) and good photocatalytic property have been obtained by pyrolyzing at 600°C for 4 h an ammonium titanyl double sulfate precursor (α-(NH₄)₂TiO(SO₄)₂) synthesized via a redox approach, that is, by oxidizing an aqueous solution of titanium trichloride (TiCl₃) with ammonium peroxodisulfate ((NH₄)₂S₂O₈), followed by reacting with ammonium sulfate ((NH₄)₂SO₄).     

Pyroelectric infrared detector for precision earth sensor

Two new types of infrared detectors have been developed for the precision earth sensor in the three axis stabilized satellite, Engineering Test Satellite VI (ETS-VI). Both detectors have a pair of infrared sensing elements, each of which is made of a pyroelectric material and mounted on an immersion lens. A-type element is a flake of lead titanate ceramic, and B-type is a sputtered epitaxial film of calcium-modified lead titanate. The precision earth sensor consists of a scanning mirror and an infrared telescope containing an objective lens, plus either type of infrared detector. Detectivity of each type at 120Hz, which is the nominal frequency of the earth sensor's signal, is 1.5×10⁹Hz^1/2/W(A-type) and 2.7×10⁹Hz^1/2/W(B-type) at 14～16.25μm. Each value is 2.5 and 4.5 times as high as the previous model in ETS-V. A-type detector passed the space environmental test and the random error cf attitude measurement was 0.03 deg with the preliminary model of the earth sensor being ahead of the breadboard model. This measurement accuracy is nearly equal to that of the foremost earth sensor. A-type was chosen as the detector for ETS-VI. The random error of the earth sensor with B-type detector is 0.012deg, smaller than a half of the A-type sensor's error. Investigation of B-type is being continued in order to confirm its reliability for space use.     

Enhanced human tumor cell transplantability in a new congenic immunodeficient mouse; KSN-BNX

We introduced two mutant genes (beige; bg that induces the deficiency of natural killer (NK) activity and xid that decreases the production of immunoglobulin) into KSN nude mice with high reproductive performances. We produced KSN bg/bg(nu/nu) (KSN-bg), KSN-xid/xid(nu/nn) (KSN-xid), KSN xid/xid,bg/bg(nu/nu) (KSN-BNX) and KSN-nu/+ (KS) mice by back-cross (cross-intercross method). All strains showed as high a reproductivity rate as the parental KSN mice. KSN-xid and KSN-BNX mice had a reduced percentage of B220 positive cells in the spleens compared to KSN and KSN-bg mice, but they showed increased percentages of Thy-1 and asialo GM1 positive cells. The serum immunoglobulin concentrations of KSN-BNX were as low as KSN-xid. Both KSN-bg and KSN-BNX mice showed deficient NK activity in spleens, whereas KSN-xid mice showed an elevated NK activity. Compared to nude mice, the growth of both human tumor cell TCO-1 and BxPc-3 transplanted subcutaneously was enhanced in KSN-BNX mice. However Panc-1 cells that was rejected in nude mice was not accepted in KSN-BNX mice. Liver metastasis of human pancreatic tumor cells; Capan-1, BxPc-3 and MIAPaCa-2 were studied. No significant difference was observed in the percentage of metastasis formed mice between nude and KSN-BNX mice.     

Iodine-initiated,solid-state copolymerization of tetraoxane with 1,3-dioxolane in the presence of methylal. III. Study on larger-scale copolymerization

The iodine-initiated, solid-state copolymerization of tetraoxane with 1,3-dioxolane in the presence of methylal has been studied using 15 l kneader-type reactor. Effects of the addition method of the 1,3-dioxolane–methylal solution on the copolymerization has been mainly discussed. The copolymerization rate, intrinsic viscosity, and thermal stability of the copolymer were found to be largely dependent on the addition method of the 1,3-dioxolane-methylal solution, i.e., if the solution is added all at once, properties of the copolymer are different at the early stage then at the later stage of the copolymerization, while on successive addition of the solution, the copolymer properties become almost constant irrespective of the polymerization time. Therefore, it was suggested that 1,3-dioxolane and methylal can easily diffuse through the copolymer layer formed on the surface of the tetraoxane particle and reacts with an active center as copolymerization proceeds.     

Filter-embedding semiring fusion for programming with MapReduce

We show that MapReduce, the de facto standard for large scale data-intensive parallel programming, can be equipped with a programming theory in calculational form. By integrating the generate-and-test programming paradigm and semirings for aggregation of results, we propose a novel parallel programming framework for MapReduce. The framework consists of two important calculation theorems: the shortcut fusion theorem of semiring homomorphisms bridges the gap between specifications and efficient implementations, and the filter-embedding theorem helps to develop parallel programs in a systematic and incremental way.