Expert judgments of hypnosis from subjective state reports.

Suggestibility was assessed in 60 college students after a traditional hypnotic induction, an alert induction, progressive relaxation training, or instruction in goal-directed imagery. Responsiveness to suggestion did not differ between groups. Ss also generated open-ended reports of their states of awareness and of their experience of 3 hypnotic suggestions. A sample of these reports from 24 moderately to highly suggestible Ss were evaluated by 18 experts in the field of hypnosis. Expert ratings of Ss' open-ended reports indicated that (1) traditional hypnotic inductions produce a state of consciousness that is indistinguishable from nonhypnotic relaxation training, (2) the subjective experience of hypnotic suggestions after imagination training is indistinguishable from that after hypnotic inductions, and (3) suggestibility is unrelated to state of consciousness as assessed by experts. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Structural reanalysis for topological modifications – a unified approach

A unified approach for structural reanalysis of all types of topological modifications is presented. The modifications considered include various cases of deletion and addition of members and joints. The most challenging problem where the structural model is itself allowed to vary is presented. The two cases, where the number of degrees of freedom is decreased and increased, are considered. Various types of modified topologies are discussed, including the common conditionally unstable structures. The solution procedure is based on the combined approximations approach and involves small computational effort. Numerical examples show that accurate results are achieved for significant topological modifications. Exact solutions are obtained efficiently for modifications in a small number of members. Received April 4, 2000     

Improved Ge Surface Passivation With Ultrathin SiOX Enabling High-Mobility Surface Channel pMOSFETs Featuring a HfSiO/WN Gate Stack

To realize high-mobility surface channel pMOSFETs on Ge, a 1.6-nm-thick SiO_X passivation layer between the bulk Ge substrate and HfSiO gate dielectric was introduced. This approach provides a simple alternative to epitaxial Si deposition followed by selective oxidation and leads to one of the highest peak hole mobilities reported for unstrained surface channel pMOSFETs on Ge: 332 cm² middotV^-1middots^-1 at 0.05 MV/cm-a 2times enhancement over the universal Si/SiO₂ mobility. The devices show well-behaved output and transfer characteristics, an equivalent oxide thickness of 1.85 nm and an I_ON/I_OFF ratio of 3times10³ without detectable fast transient charging. The high hole mobility of these devices is attributed to adequate passivation of the Ge surface     

Imidyl radicals. 3. Stereoselectivity of radical additions of N‐haloimides to cyclic alkenes

The addition of N‐haloimides ( 1 – 5 ) to alkenes 9 via imidyl radicals 6 – 8 introduces a halogen atom and an imidyl moiety to vicinal C‐atoms of a carbon chain. With cyclic alkenes, the trans/cis‐stereoselectivity depends on the nature of the imidyl unit, on the halogen atom, and on the alkene and varied between 58 : 42 and >95 : <5. Temperature dependend studies showed higher trans/cis‐selectivities at elevated temperatures, which may be caused by different conformations of the adduct radicals 10 – 12 , each of them exhibiting a different stereoselectivity.     

The SCC BJT: a high-performance bipolar transistor compatible withhigh-density deep-submicrometer BiCMOS SRAM technologies

We present the process development and device characterization of the Selectively Compensated Collector (SCC) BJT specifically designed for high-density deep-submicrometer BiCMOS SRAM technologies. This double-poly BJT takes advantage of the self-aligned polysilicon layers of the SRAM bit cell to obtain high performance without adding excessive process complexity. Furthermore, although an NPN device, the SCC BJT is formed in a lightly doped p-well in which the collector is formed with a single 370 keV phosphorus implant to minimize parasitic junction capacitances without the use of trench isolation or recessed oxides. The suitability of this bipolar structure outside of its original FSRAM intent is proven with its potential for bipolar logic and mixed-mode RF applications. ECL delays of 50 ps at 200 μA and a CML power-delay product of 4.5 fJ at 1.1 V supply were obtained. A 900 MHz noise figure as low as 0.54 dB at 0.5 mA with an associated gain of 14.7 dB was demonstrated as well as a dual modulus ÷4/5 prescaler operating up to 3.3 GHz for a switch current of 200 μA     

Estimation of intrinsic and reflex contributions to muscle dynamics: a modeling study

This work evaluated system identification-based approaches for estimating stretch reflex contributions to muscle dynamics. Skeletal muscle resists externally imposed stretches via both intrinsic stiffness properties of the muscle and reflexively mediated changes in muscle activation. To separately estimate these intrinsic and reflex components, system identification approaches must make several assumptions. We examined the impact of making specific structural assumptions about the intrinsic and reflex systems on the system identification accuracy. In particular, we compared an approach that made specific parametric assumptions about the reflex and intrinsic subsystems to another that assumed more general nonparametric subsystems. A simulation-based approach was used so that the "true" characters of the intrinsic and reflex systems were known; the identification methods were judged on their abilities to retrieve these known system properties. Identification algorithms were tested on three experimentally based models describing the stretch reflex system. Results indicated that the assumed form of the intrinsic and reflex systems had a significant impact on the stiffness separation accuracy. In general, the algorithm incorporating nonparametric subsystems was more robust than the fully parametric algorithm because it had a more general structure and because it provided a better indication of the appropriateness of the assumed structure.     

Sequential protection-modification method for selective sulfhydryl group derivatization in proteins having more than one cysteine

The method of Smith and Hartman [J. Biol. Chem., 263, 4921-4925(1988)] for introducing the non-natural lysine analog, S-(2-aminoethyl)cysteine,into specific sites in proteins by alkylation of a geneticallyintroduced cysteine with 2-bromoethylamine has been generalizedto be applicable to proteins containing one or more endogenouscysteines. The target cysteine residue introduced at the activesite of aspartate aminotransferase is protected by bound cofactor.The enzyme is partially unfolded in low concentrations of urea,and the non-active site cysteine residues derivatized by a reversiblethiol protecting reagent. The active site cysteine is then exposedand alkylated in 6 M urea. Enzyme activity is regenerated byremoval of the thiol protecting groups and refolding of theprotein.     

Intentional and spontaneous imagery in hypnosis: the phenomenology of hypnotic responding

Students were given 1 of 2 versions of the Carleton University Responsiveness to Suggestion Scale (CURSS): (a) the original version, which contains instructions to intentionally imagine goal-directed fantasies, and (b) a modified version, in which instructions for suggestion-related imagery were deleted. Participants were asked to report their goal-directed fantasies and to indicate whether these occurred spontaneously or were generated intentionally. They were also asked whether they had tried intentionally to generate the suggested experience and to indicate whether they had believed that the suggested states of affairs were real (e.g., whether they thought a hallucinated cat really existed). The deletion of instructions for goal-related imagery significantly increased responsiveness to CURSS suggestions. Spontaneous goal-directed imagery was significantly correlated with behavioral response, but intentional imagery was not. Most successful responders tried to generate suggested experiences intentionally, indicated that they could have resisted challenge suggestions if they really wanted to, and reported believing in the reality of suggested ideomotor and challenge experiences but not of cognitive suggestions. Voluntary attempts to generate suggested experiences were correlated with subjective responding.     

Development of a lyophilized formulation for (R,R)-formoterol (L)-tartrate

(R,R)-formoterol is a beta-agonist for inhalation. Aqueous instability suggested the need for a reconstitutable lyophilized dosage form. The objective of these studies was to devise a stable, rapid-dissolving, therapeutically compatible dosage form. The effects of diluents and residual moisture on the stability of thermally stressed formoterol formulations were investigated. Drug and various excipients (acetate, lactose, and mannitol) were lyophilized and placed in humidity chambers (0 to 90% relative humidity) at 25 to 50 degrees C. Stability was characterized by time-dependent changes using HPLC, pH, and XRD. Residual moisture were determined by Karl Fisher methods. Regression models were developed to quantify the effects of formulation and environmental variation on drug stability. Solid-state instability was observed as a function of high residual moisture and diluent type. Although the residual moisture in mannitol formulations were typically below 1%, the degradation rate (50 degrees C) varied from 2 to 10 mcg/day, which was 1.3- to 20-fold high than observed for lactose formulations under the same relative humidity conditions. At high relative humidity, the presence of acetate significantly increased the degradation rate (p < 0.04). The critical residual moisture content for lactose formulations was 3%. The amount of lactose was optimized by evaluating the degradation over the temperature range 25 to 50 degrees C. Mannitol and acetate were shown to be unsuitable excipients, and an optimal lactose amount was 50 mg for vials containing 50 mcg of drug.     

Formation of organic chlorine in activated sludge effluents

Bench scale activated sludge reactors with a solids retention time of 9 days were operated at all combinations of two levels of pH, dissolved oxygen (DO) concentration and feed type (pH 6 and 8; DO 1 and 7 mg 1⁻¹; simple and complex feed). Long-term composite samples were collected and adjusted to neutral pH and equal concentrations of alkalinity and ammonia nitrogen. They were then breakpoint chlorinated with NaO³⁶Cl in order to determine how much chlorine was incorporated into the organic matter. The amounts ranged from 0.019 to 0.067 mg atomic chlorine incorporated per mg soluble organic carbon. Analysis of variance revealed that the DO concentration was the only independent variable to have a significant effect upon the amount of chlorine incorporated, with reactors operated at high DO levels generally producing effluent organics which were less susceptible to adding chlorine.