New results in robust actuator fault reconstruction for linear uncertain systems using sliding mode observers

This paper presents a robust actuator fault reconstruction scheme for linear uncertain systems using sliding mode observers. In existing work, fault reconstruction via sliding mode observers is limited to either linear certain systems subject to unknown inputs, relative degree one systems or a specific class of relative degree two systems. This paper presents a new method that is applicable to a wider class of systems with relative degree higher than one, and can also be used for systems with more unknown inputs than outputs. The method uses two sliding mode observers in cascade. Signals from the first observer are processed and used to drive the second observer. Overall, this results in actuator fault reconstruction being feasible for a wider class of systems than using existing methods. A simulation example verifies the claims made in this paper. Copyright © 2007 John Wiley & Sons, Ltd.     

Geometry dependence of microstructure and microhardness for selective electron beam-melted Ti–6Al–4V parts

In an additive-manufactured metallic part, distinct and different microstructure and mechanical properties may exist in different areas due to differences in shape and location. Two parts, one with straight-finned structure and the other with curve-finned structure, were fabricated by the selective electron beam melting method using pre-alloyed Ti–6Al–4V ELI powder. Microstructural characterisation of these two parts that have varying fin thickness and shape was carried out to investigate the synthetical influence of 2D planar build geometry and in-fill hatching strategy on selective electron beam melting. It was found that the β interspacing is larger in the curve-finned structure, leading to a lower microhardness as compared to the straight-finned structure. It suggests a slower cooling rate in the curve-finned structure due to the differences in build geometry and in-fill hatching strategy.     

Recurrent neural network approach for cyclic job shop scheduling problem

While cyclic scheduling is involved in numerous real-world applications, solving the derived problem is still of exponential complexity. This paper focuses specifically on modelling the manufacturing application as a cyclic job shop problem and we have developed an efficient neural network approach to minimise the cycle time of a schedule. Our approach introduces an interesting model for a manufacturing production, and it is also very efficient, adaptive and flexible enough to work with other techniques. Experimental results validated the approach and confirmed our hypotheses about the system model and the efficiency of neural networks for such a class of problems.     

Limit cycles induced in type-1 linear systems with PID-type of relay feedback

This article investigates the limit cycles within type-1 linear systems under PID-type of relay feedback. The problem is generalised from the identification of friction models of servo mechanical systems via limit-cycle experiments under dual-channel relay feedback. Locations of limit cycles are given so that the exact durations between two consecutive switchings of relays can be determined via numerical computation. After this, local stability of limit cycles can be checked via the Jacobian of Poincaré map. Examples are analysed using proposed theorems.     

Minimizing control variation in nonlinear optimal control

In any real system, changing the control signal from one value to another will usually cause wear and tear on the system’s actuators. Thus, when designing a control law, it is important to consider not just predicted system performance, but also the cost associated with changing the control action. This latter cost is almost always ignored in the optimal control literature. In this paper, we consider a class of optimal control problems in which the variation of the control signal is explicitly penalized in the cost function. We develop an effective computational method, based on the control parameterization approach and a novel transformation procedure, for solving this class of optimal control problems. We then apply our method to three example problems in fisheries, train control, and chemical engineering.     

BSEM estimation of network effect and customer orientation empowerment on trust in social media and network environment

This paper presents a stochastic model that identifies network effect and customer orientation empowerment as strong antecedents of trustworthiness and trust in social media network environment. As Trust is emerging as a critical influencer of consumer behavior in organizations, social media has become the facilitator or the enabler of this influence. This paper aims to explore and examine the relationships amongst the antecedents of trust in the context of the social media network environment via Bayesian estimation and testing of the structural equation model. In facilitating the estimation of the stochastic model, a survey was conducted on 255 social media users. A series of statistical analyses were conducted prior to the estimation using Bayesian Markov Chain Monte Carlo (MCMC). Results showed that network effect and customer orientation empowerment were significant predictors of trustworthiness and trust. Bayesian MCMC results confirmed that the findings were consistent with the literature.     

Molecular cloning of mouse glycolate oxidase. High evolutionary conservation and presence of an iron-responsive element-like sequence in the mRNA

Iron regulatory proteins (IRPs) control the synthesis of several proteins in iron metabolism by binding to iron-responsive elements (IREs), a hairpin structure in the untranslated region (UTR) of corresponding mRNAs. Binding of IRPs to IREs in the 5' UTR inhibits translation of ferritin heavy and light chain, erythroid aminolevulinic acid synthase, mitochondrial aconitase, and Drosophila succinate dehydrogenase b, whereas IRP binding to IREs in the 3' UTR of transferrin receptor mRNA prolongs mRNA half-life. To identify new targets of IRPs, we devised a method to enrich IRE-containing mRNAs by using recombinant IRP-1 as an affinity matrix. A cDNA library established from enriched mRNA was screened by an RNA-protein band shift assay. This revealed a novel IRE-like sequence in the 3' UTR of a liver-specific mouse mRNA. The newly identified cDNA codes for a protein with high homology to plant glycolate oxidase (GOX). Recombinant protein expressed in bacteria displayed enzymatic GOX activity. Therefore, this cDNA represents the first vertebrate GOX homologue. The IRE-like sequence in mouse GOX exhibited strong binding to IRPs at room temperature. However, it differs from functional IREs by a mismatch in the middle of its upper stem and did not confer iron-dependent regulation in cells.     

The venotonic drug hydroxyethylrutosiden does not prevent or reduce docetaxel-induced fluid retention: results of a comparative study

PURPOSE: Fluid retention, which includes peripheral edema, ascites, pleural or pericardial effusion, or a combination of these that is sometimes associated with significant weight gain, is one of the most troublesome cumulative side effects of docetaxel. A suggestive observation from the data base available at the manufacturer (Rhone-Poulenc Rorer) was that patients who received venotonic drugs appeared to tolerate more courses of docetaxel. This prompted a comparative study to investigate whether the venotonic drug hydroxyethylrutosiden could reduce or delay docetaxel-related fluid retention. METHODS: A total of 85 patients with metastatic breast cancer who were treated with docetaxel at a dose of 100 mg/m2 with corticoid comedication were allocated to receive either 300 mg hydroxyethylrutosiden given orally four times daily (group A) or no hydroxyethylrutosiden (group B). The end point for analysis was the development of fluid retention of > or = grade 2. RESULTS: Fluid retention of > or = grade 2 was reported in 14 of 42 patients (33%) in group A and in 15 of 43 patients (35%) in group B and occurred after a median of 4 cycles of docetaxel in both groups. Weight gain was similar in groups A and B. CONCLUSION: We conclude that hydroxyethylrutosiden does not reduce or delay the incidence and severity of docetaxel-related fluid retention.