Second-harmonic generation at 0.659 µ in CD*A

The efficient generation of the second-harmonic radiation of an Nd:YAG laser operating at 1.318 μ has been achieved in a deuterated cesium dihydrogen arsenate (CD*A) crystal. An overall peak power conversion efficiency of 40 percent was obtained for the experimental conditions described.     

High-quality broad-band optical communication by time-division multiplexed pulse analog modulation: Nonlineary in diode lasers

Inter/cross modulation levels occurring in signals from stripe-geometry (GaAl)As double-heterostructure diode lasers are investigated by computer simulation for the case of time-division multiplexed (TDM) pulse-analog modulation (PAM). It is shown that pulse-position modulation (PPM) is the preferred modulation scheme for high pulse rates, and inter/cross modulation levels are evaluated for the format TDM-PPM. It is shown that the inter/cross modulation level is greatly improved when diode lasers are biased above threshold. Based on this evaluation, it is concluded that effectively inter/cross modulation-free optical transmission at a pulse rate up to108 times 10^{6}pulses per second by TDM-PPM is feasible. This limiting rate permits the transmission of 12 color TV channels or 10800 telephony channels.     

L-Norvaline and L-homoisoleucine formation by Serratia marcescens,

Two unnatural amino acids were found as by-products in isoleucine fermentation from threonine by Serratia marcescens. These amino acids were identified as L-norvaline (2-aminopentanoic acid) and L-homoisoleucine (2-amino-4-methylhexanoic acid). Formation of L-norvaline and L-homoisoleucine was not observed when L-leucine was added to the medium. The leucine auxotroph derived from the isoleucine accumlator did not produce L-norvaline or L-homoisoleucine even during the accumulation of large amounts of isoleucine. It is suggested that L-norvaline and L-homoisoleucine formation is closely related to leucine biosynthesis.     

Flaujeac factor deficiency. Reconstitution with highly purified bovine high molecular weight-kininogen and delineation of a new permeability-enhancing peptide released by plasma kallikrein from bovine high molecular weight-kininogen

Flaujeac trait is the functional deficiency of a plasma protein of the intrinsic coagulation, kinin-forming, and plasma fibrinolytic pathways. The Flaujeac factor in man has been isolated and tentatively identified as a kininogen of high molecular weight (HMW). Highly purified bovine HMW-kininogen, but not bovine low molecular weight kininogen, repaired Flaujeac factor deficiency. The two subspecies of this molecule, HMW-kininogen a and HMW-kininogen b, also corrected Flaujeac factor deficiency. When bovine HMW-kininogen was incubated with bovine plasma kallikrein, kinin-free HMW-kininogen, bradykinin, and a glycopeptide fragment (peptide 1-2; 12,584 daltons) were rapidly released. None of these fragmentation products corrected Flaujeac factor deficiency alone or in mixtures. The function of HMW-kininogen appeared to depend upon the structural integrity of the native molecule. When injected in concentrations of 2 pmol-8 nmol/0.1 ml, peptide 1-2 caused increased vascular permeability in rabbits, rats, or guinea pigs. The enhanced permeability was maximal within 1-2 min and terminated in 5-10 min, differing from that of bradykinin or histamine. Injected together in equimolar amounts, peptide 1-2 and bradykinin produced a synergistic permeability response which was immediate in onset as well as prolonged in duration. Peptide 1-2 is a rapidly acting, highly basic glyco-peptide which mediates increased vascular permeability in a complementary and synergistic manner with bradykinin.     

A possible activation of cholesterol 7-hydroxylation by S-methylmethionine (vitamin U)

The conversion rate from 14 C-cholesterol to its 7 alpha-hydroxylated metabolites was studied in the microsome system prepared from mice liver with the pretreatment of S-methylmethionine (MMSC). In results, the increased amounts of 7 alpha-hydroxylated metabolites by MMSC show a possible activation of cholesterol 7 alpha-hydroxylase.     

Studies on the synthesis of proteinase inhibitors. II. Synthesis of cyclic nonapeptide fragments and analogs related to the reactive sites of soybean Bowman-Birk inhibitor

Several heterodetic cyclic nonapeptides modeled after the disulfide loops of Bowman-Birk inhibitor which involve either the anti-tryptic or anti-chymotryptic region have been synthesized by the conventional method. The inhibitory properties and the stabilities of these peptides toward trypsin and chymotrypsin, as well as the properties of dimers of the above nonapeptides, were examined.     

Side-milling technique of preparing device cross-sections for electron holography based on a focused ion beam micro-sampling system

A new milling technique based on a focused ion beam (FIB) microsampling system is proposed to avoid the curtaining effect, commonly occurring in other FIB milling methods, in order to obtain a crosssectional device specimen with uniform thickness can be obtained for electron holographic observation.     

Liquid holdup and heat transfer coefficient between bed and wall in liquid solid and gas-liquid-solid fluidized beds

In fluidized beds of 0.052 and 0.12 m i.d. air, water and aqueous solutions of carboxymethyl cellulose (viscosity = 9.0 X 10^-4- 52 X 10^-2 Pa s), and glass beads were used as gas, liquid and solid phase, respectively. The diameters of the glass beads were 4.2 X 10^-4 6.6 X 10^-4 1.2 X l0^-3, and 2.2 X 10^-3 m.The liquid holdup in the gas-liquid-solid fluidized bed was well correlated by modifying the Garside and Al-Dibouni's equation with the gas phase Froude number.The wall heat transfer coefficient of the gas-liquid-solid fluidized beds in the range of stable fluidization state runs correlated as a function of modified Nusselt number, modified Reynolds number and gas phase Froude number.