矿热炉参数计算的探讨

从传统的电炉参数计算公式出发，推导出符合实际的新参数计算方法，新方法大大减少了传统选择电炉参数的随意性，与实际紧密结合，可以有预见地设计和优化电炉参数，从而使电炉参数达到最佳的冶炼效果。     

绝热指数为1的一维非等熵流气体动力学方程组Cauchy问题

考虑绝热指数为１的一维非等熵流气体动力学方程组ｕｔ＋ｐ（ｖ，ｓ）ｘ＝０ｖｔ－ｕｘ＝０ｓｔ＝０在熵的振幅“小性”条件下，证明了其以Ｃａｕｃｈｙ问题光滑解的整体存在性定理。     

Identification of Sortilin Alternatively Spliced Variants in Mouse 3T3L1 Adipocytes

Type 2 diabetes mellitus is a metabolic disorder defined by systemic insulin resistance. Insulin resistance in adipocytes, an important regulator of glucose metabolism, results in impaired glucose uptake. The trafficking protein, sortilin, regulates major glucose transporter 4 (Glut4) movement, thereby promoting glucose uptake in adipocytes. Here, we demonstrate the presence of an alternatively spliced sortilin variant (Sort^17b), whose levels increase with insulin resistance in mouse 3T3L1 adipocytes. Using a splicing minigene, we show that inclusion of alternative exon 17b results in the expression of Sort^17b splice variant. Bioinformatic analysis indicated a novel intrinsic disorder region (IDR) encoded by exon 17b of Sort^17b. Root mean square deviation (RMSD) and root mean square fluctuation (RMSF) measurements using molecular dynamics demonstrated increased flexibility of the protein backbone within the IDR. Using protein–protein docking and co-immunoprecipitation assays, we show robust binding of Glut4 to Sort^17b. Further, results demonstrate that over-expression of Sort^17b correlates with reduced Glut4 translocation and decreased glucose uptake in adipocytes. The study demonstrates that insulin resistance in 3T3L1 adipocytes promotes expression of a novel sortilin splice variant with thus far unknown implications in glucose metabolism. This knowledge may be used to develop therapeutics targeting sortilin variants in the management of type 2 diabetes and metabolic syndrome.     

CD26 Induces Colorectal Cancer Angiogenesis and Metastasis through CAV1/MMP1 Signaling

CD26 has been reported as a marker for colorectal cancer stem cells endowed with tumor-initiating properties and capable of colorectal cancer (CRC) metastasis. In this study, we investigated the functional effect of CD26 on CRC angiogenesis and metastasis, and the potential underlying mechanism. The functional effects of CD26 overexpression or repression were determined by a wound healing experiment, and cell migration and invasion assays in vitro and in mouse models. Differentially expressed genes regulated by CD26 were identified by genome-wide mRNA expression array and validated by quantitative PCR. CD26 functionally regulated CRC cell migration and invasion in vitro and angiogenesis and metastasis in vivo. Genome-wide mRNA expression array and qPCR showed that MMP1 was up-regulated in CD26+ subpopulation, and a subsequent experiment demonstrated the regulatory effect of CD26 on MMP1 in CRC cell lines with CD26 repression or overexpression. Furthermore, overexpression of CAV1 abrogated the CD26-regulated MMP1 induction in CRC cell lines. This study demonstrated the functional roles of CD26 in inducing CRC migration, invasion, angiogenesis and metastasis and identified the potential involvement of MMP1 and CAV1 in such process. CD26 is an attractive therapeutic target for combating tumor progression to improve the prognosis of CRC patients.     

百合多糖脱蛋白方法的研究

研究中对几种百合多糖脱蛋白方法进行了对比实验，结果显示采用酶法与Seveage法联用法效果最好，是一种有效的植物多糖中的脱蛋白方法。     

石材风化、矿物含量、节理发育对石材表面光泽度的影响

光泽度是石材经抛光后反光能力的量度。数除加工工艺的因素外与石材本身的风化程度、也称反射系数,是评价石材品质的主要参数。反射系矿物成分、色斑、色线及节理发育情况密切相关。     

Differential evolution variants to schedule flexible assembly lines

Scarce resources such as material, labor, and equipment are to be optimized to improve the performance and lower production costs in flexible assembly lines. These resources are usually allocated optimally through the generation of schedules. In this paper, variants of a differential evolution-based algorithm are employed to schedule flexible assembly lines (FAL). The performance of the assembly line is optimized based on two performance criteria, namely the weighted sum of Earliness/Tardiness penalties and the balance of the assembly line. Different variants of the Bi-level differential evolution (BiDE) algorithms are developed to study the effects of three FAL problems. The parameters of BiDE algorithm for FAL problems are fine-tuned. The performance of the BiDE algorithm is evaluated using the datasets and the Bi-level Genetic Algorithm (BiGA) available in the literature. The experimental results show that the proposed differential evolution-based algorithm outperforms BiGA in terms of mean best fitness.     

完全格上单调函数的不动点定理及其应用

给出一个完全格上单调函数的不动点定理，然后利用此定理给出关于超穷基数的Ｃａｎｔｏｔ－Ｓｃｔｒｏｄｅｒ－Ｂｅｒｎｓｔｅｉｎ定理的一种证明．     

高层建筑顺风响应的计算

本文计算了高层建筑在顺风荷载作用下的动力反应.根据基本参数、结构第一振型和质量模式的假定,编制了计算程序AWCTS.对国外三幢高楼进行计算,检验了本文提出风荷载模型的有效性.