The role of glutathione in dopaminergic neuronal survival

An increased production of reactive oxygen species is thought to be critical to the pathogenesis of Parkinson's disease. At autopsy, patients with either presymptomatic or symptomatic Parkinson's disease have a decreased level of glutathione in the substantia nigra pars compacta. This change represents the earliest index of oxidative stress in Parkinson's disease discovered to this point. This study compares the sensitivity of dopaminergic and nondopaminergic neurons in dissociated mesencephalic cultures to the depletion of glutathione. We have found that dopaminergic neurons are more resistant to the toxicity of glutathione depletion than nondopaminergic neurons. The possibility that dopaminergic neurons have a higher baseline glutathione level than nondopaminergic neurons is suggested by measurements of levels of cellular glutathione in a parallel system of immortalized embryonic dopaminergic and nondopaminergic cell lines. We also examined the role of glutathione in 1-methyl-4-phenylpyridinium toxicity. Decreasing the glutathione level of dopaminergic neurons potentiates their susceptibility to 1-methyl-4-phenylpyridinium toxicity, although 1-methyl-4-phenylpyridinium does not deplete glutathione from primary mesencephalic cultures. Our data suggest that although a decreased glutathione content is not likely to be the sole cause of dopaminergic neuronal loss in Parkinson's disease, decreased glutathione content may act in conjunction with other factors such as 1-methyl-4-phenylpyridinium to cause the selective death of dopaminergic neurons.     

发展创新民族风格的包装设计

首先揭示出民族风格是与时代风格对立统一、相互依存的一个概念。因而特定的时代需要具有时代精神的民族风格──创新民族风格。在探索此风格的过程中．我们首先要学习日本的战略，然后在学习的基础上实现超越。     

Matrix unit cell scheduler (MUCS) for input-buffered ATM switches

This paper presents a novel matrix unit cell scheduler (MUCS) for input-buffered asynchronous transfer mode (ATM) switches. The MUCS concept originates from a heuristic strategy that leads to an optimal solution for cell scheduling. Numerical analysis indicates that input-buffered ATM switches scheduled by MUCS can utilize nearly 100% of the available link bandwidth. A transistor-level MUCS circuit has been designed and verified using HSPICE. The circuit features a regular structure, minimal interconnects, and a low transistor count. HSPICE simulation indicates that using 2-μm CMOS technology, the MUCS circuit can operate at clock frequency of 100 MHz     

Statistical estimation of average power dissipation usingnonparametric techniques

In this paper, we present a new statistical technique for estimation of average power dissipation in digital circuits. The present parametric statistical technique estimates the average power based on the assumption that the power distribution can be characterized by a preassumed function. Large error can incur when the assumption is not met. On the other hand, the existing nonparametric technique, although accurate, is too conservative and requires a large sample size in order to achieve convergence. For a good tradeoff between simulation accuracy and computational efficiency, we propose a new nonparametric technique using the properties of the order statistics. It is generally applicable to any type of circuit irrespective of its power distribution function. Compared to the existing nonparametric technique, it is much more computationally efficient since it requires a much smaller sample size to achieve the same accuracy specification. This new technique is implemented in the distribution-independent power estimation tool (DIPE). DIPE is empirically demonstrated to be more robust and accurate than the parametric technique     

Interdiffusion behavior of Hg in HgTe/CdTe superlattices grown on Cd0.96Zn0.04 Te (211)B substrates by molecular beam epitaxy

Double-crystal x-ray rocking curve (DCRC) and secondary-ion mass-spectroscopy (SIMS) measurements have been performed to investigate the effect of rapid thermal annealing on the interdiffusion behavior of Hg in HgTe/CdTe superlattices grown on Cd_0.96Zn_0.04Te (211)B substrates by molecular beam epitaxy. The sharp satellite peaks of the DCRC measurements on a 100-period HgTe/CdTe (100Å/100Å) superlattice show a periodic arrangement of the superlattice with high-quality interfaces. The negative direction of the entropy change obtained from the diffusion coefficients as a function of the reciprocal of the temperature after RTA indicates that the Hg diffusion for the annealed HgTe/CdTe superlattice is caused by an interstitial mechanism. The Cd and the Hg concentration profiles near the annealed HgTe/CdTe superlattice interfaces, as measured by SIMS, show a nonlinear behavior for Hg, originating from the interstitial diffusion mechanism of the Hg composition. These results indicate that a nonlinear interdiffusion behavior is dominant for HgTe/CdTe superlattices annealed at 190°C and that the rectangular shape of HgTe/CdTe superlattices may change to a parabolic shape because of the intermixing of Hg and Cd due to the thermal treatment.     

Reliability and performance analysis of time – space – time switching networks with multiple separated space switches

Since electronic switching systems usually require very strict reliability requirements as well as good performance objectives, we need to jointly analyse the performance and reliability of switching systems. In this paper, we compare conventional time–space–time switches with single space switches with those with multiple separated space switches, from the viewpoints of reliability and performance. We consider time–space–time switching networks which consist of N incoming time switches, i.e. one NxN space switch, two (N/2)x(N/2) space switches, and four (N/4)x(N/4) space switches. We introduce a Markov reliability model to study the effect of failures and analyse the reliability and performance of three different types of switching networks in terms of average blocking probability and the mean time to unreliable operation, as we vary the offered traffic. As a result, T–S–T switching networks with multiple separated space switches exhibit better performance and reliability than those with single space switches.     

Al,Ga取代Bi：DyIG薄膜的磁和磁光特性的研究

本文报道用热分解法在玻璃衬底上制备了Ａｌ和Ｇａ取代的Ｂｉ：ＤＹＩＧ薄膜，对其磁和磁光特性做了详细研究．Ａｌ和Ｇａ取代的薄膜均可获得好的矩形比和高的矫顽力．对于Ｂｉ１．２Ｄｙ１．８Ｆｅ５－ｘＭＸＯ１２（Ｍ＝Ａ１，ＧＺ）薄膜，Ａ１和Ｇ２的最佳替代成份分别为１．０和Ｇ．７；最佳晶化温度分别为７００ｏ℃和６７５℃．在波长５１０ｎｍ附近，法拉第旋转角可达８°／ｕｍ左右．光学吸收和品质因子的研究结果表明，Ａｌ和Ｇａ取代能够影响光学吸收和品质因子，其中Ｇａ取代对光学吸收和品质因子的影响较大．     

离子注入对Cr12MoV钢表面组织结构和力学性能的影响

研究了Ｃｒ１２ＭｏＶ钢离子注入层的显微组织特征及其对表面性能的影响。结果表明，离子注入使Ｃｒ１２ＭｏＶ钢的表面硬度和耐磨性能得到显著改善，且存在着一个最佳的注入剂量，约为３×１０＾１＾７Ｎ＾＋／ｃｍ＾２左右。离了注入在Ｃｒ１２ＭｏＶ钢表面层中形成了大量细小弥散的第二相粒子，并使α－Ｆｅ晶格发生严重畸变，从而引起材料表面强化。     

Modified atmosphere packaging of a mixed prepared vegetable salad dish

The aim of this study was to design a modified atmosphere package for a mixed vegetable salad consisting of 75 g of cut carrot, 55 g of cut cucumber, 20 g of sliced garlic and 50 g of whole green pepper. Respiration data of all the components were combined with film permeability data to predict package atmospheres and design optimal packages for experimental testing for improved shelf-life of the produce. The optimal package avoided minimum O₂ and maximum CO₂ tolerance limits, and chilling injury temperatures for any component. A pouch form package made of 27 mm low density polyethylene developed a modified atmosphere of 2.0–2.1% O₂ and 5.5–5.7% CO₂, which was beneficial for all components and provided better quality retention than other test packages.     

Si_（1－x）Ge_x／Si定向耦合器的研制

在运用ＳｉＧｅ脊形波导单模条件和有效折射率法分析ＳｉＧｅ／Ｓｉ定向耦合器结构参数的基础上，采用分子束外延和各向异性腐蚀技术制备出Ｓｉ１－ｘＧｅｘ／Ｓｉ（ｘ＝０．０５）单模定向耦合器．在波长为１．３μｍ时，平均串音小于－１８．１ｄＢ，输出功率耦合效率达到９８．１％