An integrative software package for gastrointestinal biomagnetic data acquisition and analysis using SQUID magnetometers

The study of bioelectric and biomagnetic activity in the human gastrointestinal (GI) tract is of great interest in clinical research due to the proven possibility to detect pathological conditions thereof from electric and magnetic field recordings. The magnetogastrogram (MGG) and magnetoenterogram (MENG) can be recorded using superconducting quantum interference device (SQUID) magnetometers, which are the most sensitive magnetic flux-to-voltage converters currently available. To address the urgent need for powerful acquisition and analysis software tools faced by many researchers and clinicians in this important area of investigation, an integrative and modular computer program was developed for the acquisition, processing and analysis of GI SQUID signals. In addition to a robust hardware implementation for efficient data acquisition, a number of signal processing and analysis modules were developed to serve in a variety of both clinical procedures and scientific investigations. Implemented software features include data processing and visualization, waterfall plots of signal frequency spectra as well as spatial maps of GI signal frequencies. Moreover, a software tool providing powerful 3D visualizations of GI signals was created using realistic models of the human torso and internal organs.     

Miniature sensor suitable for electronic nose applications

A major research effort has been devoted over the years for the development of chemical sensors for the detection of chemical and explosive vapors. However, the deployment of such chemical sensors will require the use of multiple sensors (probably tens of sensors) in a sensor package to achieve selective detection. In order to keep the overall detector unit small, miniature sensors with sufficient sensitivity of detection will be needed. We report sensitive detection of dimethyl methylphosphonate (DMMP), a stimulant for the nerve agents, using a miniature sensor unit based on piezoresistive microcantilevers. The sensor can detect parts-per-trillion concentrations of DMMP within 10 s exposure times. The small size of the sensor makes it ideally suited for electronic nose applications.     

Tools and strategies for visualization of large image data sets in high-resolution imaging mass spectrometry

Mass spectrometry based proteomics is one of the scientific domains in which experiments produce a large amount of data that need special environments to interpret the results. Without the use of suitable tools and strategies, the transformation of the large data sets into information is not easily achievable. Therefore, in the context of the virtual laboratory of enhanced science, software tools are developed to handle mass spectrometry data sets. Using different data processing strategies for visualization, it enables fast mass spectrometric imaging of large surfaces at high-spatial resolution and thus aids in the understanding of various diseases and disorders. This article describes how to optimize the handling and processing of the data sets, including the selection of the most optimal data formats and the use of parallel processing. It also describes the tools and solutions and their application in mass spectrometric imaging strategies, including new measurement principles, image enhancement, and image artifact suppression.     

The effect of interstitial air on the in vitro thrombogenicity of ePTFE vascular grafts

Gas trapped in the interstices of the biomaterials used for vascular prostheses causes thrombosis, and the process of eliminating this gas is known as denucleation. An apparatus was developed for testing in the in vitro effects of denucleation on 4 mm I.D. expanded polytetrafluoroethylene (ePTFE) Vitagraft (Johnson and Johnson). The apparatus was designed to ensure that neither the blood nor the grafts came in contact with air. Blood from a single donor was incubated with control and denucleated grafts for 5, 10, 15, 20, and 30 minutes. The thrombus volume in the graft lumen was measured with a computer assisted videometric system. Little thrombus formed by 5 or 10 minutes, but there was less thrombus in the denucleated graft than in the control graft at all times. The differences were statistically significant at 15 and 20 minutes (p < 0.05). Denucleation nearly doubled the thrombus formation time. Thrombus was more adherent to denucleated grafts than to control grafts. These results are consistent with in vivo observations in the rat where denucleation decreased thrombus formation and increased patency duration.     

Geometric modeling of inflatable structures for lunar base

A modular inflatable structure consisting of thin, composite membranes is presented for use in a lunar base. Results from a linear elastic analysis of the structure indicate that it is feasible in the lunar environment. Further analysis requires solving nonlinear equations and accurately specifying the geometries of the structural members. A computerized geometric modeling technique, using bicubic Bezier surfaces to generate the geometries of the inflatable structure, was conducted. Simulated results are used to create three-dimensional wire frames and solid renderings of the individual components of the inflatable structure. The component geometries are connected into modules, which are then assembled based upon the desired architecture of the structure.     

An efficient naturalness-preserving image-recoloring method for dichromats

We present an efficient and automatic image-recoloring technique for dichromats that highlights important visual details that would otherwise be unnoticed by these individuals. While previous techniques approach this problem by potentially changing all colors of the original image, causing their results to look unnatural to color vision deficients, our approach preserves, as much as possible, the image's original colors. Our approach is about three orders of magnitude faster than previous ones. The results of a paired-comparison evaluation carried out with fourteen color-vision deficients (CVDs) indicated the preference of our technique over the state-of-the-art automatic recoloring technique for dichromats. When considering information visualization examples, the subjects tend to prefer our results over the original images. An extension of our technique that exaggerates color contrast tends to be preferred when CVDs compared pairs of scientific visualization images. These results provide valuable information for guiding the design of visualizations for color-vision deficients.     

Order effects and the weighting process in workload assessment

Operators controlling a power grid were subjects in a mental workload experiment in which they performed their normal tasks under simulated quiet and busy conditions. Workload was assessed using the NASA Task-Load Index (TLX). It was found that there were significant differences between the two conditions, but there were no order effects. The value of the weighting procedure was assessed by correlating unweighted and weighted workload ratings. Although the correlations were high, they were not perfect, indicating some value for weighting the dimensions of the TLX. Large individual differences were observed in perceived workload.     

Porosity Depth Profiling of Thin Porous Silicon Layers by use of Variable-Angle Spectroscopic Ellipsometry: A Porosity Graded-Layer Model

Variable-angle spectroscopic ellipsometry was used to determine nondestructively the porosity depth profile and thickness of thin porous silicon layers produced by anodization of p(+)-doped silicon wafers. A porosity graded-layer model is presented and used in the analysis of the material. In the porosity graded-layer model an inhomogeneous layer is built up by several thin sublayers with the porosity changing slightly from one sublayer to the next. Results from the ellipsometry analysis and from transmission electron microscopy reveal inhomogeneous layers whose porosity and thereby optical properties change with their depth in the layers.     

Polarization-induced noise in a fiber-optic Michelson interferometer with Faraday rotator mirror elements

Faraday rotator mirror elements have been used in a number of applications as compensators for induced birefringence in retracing paths. In interferometric systems, such as the fiber-optic Michelson interferometer, this approach proved to be useful in providing maximum fringe visibility and insensitivity to the polarization state of light injected into the interferometer. However, it is found that, when the characteristics of the fiber coupler depend on the polarization state of the input beam, the efficiency of the Faraday mirror elements is limited. Theoretical analysis and experimental results in support of this statement are presented.