HSPA4 Is a Biomarker of Placenta Accreta and Enhances the Angiogenesis Ability of Vessel Endothelial Cells

Placenta accreta spectrum (PAS) accounts for 7% of maternal mortality and is associated with intraoperative and postoperative morbidity caused by massive blood loss, infection, and adjacent organ damage. The aims of this study were to identify the protein biomarkers of PAS and to further explore their pathogenetic roles in PAS. For this purpose, we collected five placentas from pregnant subjects with PAS complications and another five placentas from normal pregnancy (NP) cases. Then, we enriched protein samples by specifically isolating the trophoblast villous, deeply invading into the uterine muscle layer in the PAS patients. Next, fluorescence-based two-dimensional difference gel electrophoresis (2D-DIGE) and MALDI-TOF/MS were used to identify the proteins differentially abundant between PAS and NP placenta tissues. As a result, nineteen spots were determined as differentially abundant proteins, ten and nine of which were more abundant in PAS and NP placenta tissues, respectively. Then, specific validation with western blot assay and immunohisto/cytochemistry (IHC) assay confirmed that heat shock 70 kDa protein 4 (HSPA4) and chorionic somatomammotropin hormone (CSH) were PAS protein biomarkers. Further tube formation assays demonstrated that HSPA4 promoted the in vitro angiogenesis ability of vessel endothelial cells, which is consistent with the in vivo scenario of PAS complications. In this study, we not only identified PAS protein biomarkers but also connected the promoted angiogenesis with placenta invasion, investigating the pathogenetic mechanism of PAS.     

温度极化对膜蒸馏过程的影响研究

采用直接接触式膜蒸馏，以纯水为料液，考察了材料及结构不同的5种微孔疏水膜的渗透性能．分析结果认为，膜的渗透系数和温度极化系数共同影响着膜通量的大小．实验还考察了料液温度和流率对膜通量及热效率的影响，利用膜及膜两侧边界层内传热传质理论对此进行了分析讨论．因温度极化系数随操作温度变化，可通过控制适宜操作温度获得大膜通量和高热效率．增大料液流率可强化传热，使温度极化减弱，膜通量增加．     

基于Rough集方法的RS-MAXNET网络分类器模型

Rough集（RS）理论中如何补偿或拓展Rs约简的局部决策规则使之更加接近全局规则是一个重要的议题。本文提出RS与MAXNET网络结合拓展建立盼MAXNET全局网络分类器模型。基于上述模型进行的脱机手写模式识别算法说明了其有效性。     

服务组合的代数规约

现有的服务组合描述途径不能有效地验证和测试组合正确性,针对这一问题,提出了一个代数规约方法,引入规约包机制扩展面向服务代数规约语言SOFIA以支持该方法。用代数规约单元描述服务系统中的各种实体,其中基调部分定义实体的语法和结构,公理部分定义其功能和行为特性。与一个服务相关的规约单元封装在一个包中或拆分在几个相互引用的包中,每个包形成一个命名空间。当多个服务组合在一起时,以这些服务的代数规约包为基础,一方面抽象地定义组合服务的交互过程和语义,形成描述服务组合实现方式的实现规约包;另一方面抽象地定义组合服务对外接口及其功能语义,形成描述组合服务需求的抽象规约包。在实现规约和抽象规约的双元结构基础上,进一步定义了实现规约和抽象规约之间必须满足的“实现”关系,证明了满足实现关系可以保证实现的正确性,从而为服务组合的可验证性和可测试性奠定了理论基础。最后结合实例分析阐述了用代数规约描述服务组合的抽象性、可表达性和可验证性。     

全自动剥多芯线一体机控制系统设计

针对目前国内多芯线材内芯加工困难和生产效率低下问题,介绍了一种全自动剥多芯线控制系统.以C8051F340单片机为控制核心,采用主从式MCU结构,液晶HJ12864ZW为人机界面;主MCU设定和显示多芯线加工的相关参数及报警输出,从MCU通过串口接收主MCU的信息控制4台步进电机和捋线装置实现多芯线材的加工.通过实验表明,该控制系统可实现多芯线材裁剪、剥皮、剥内芯一体全自动加工功能,具有良好的应用前景.     

Correction strategy of fuel injection quantity during pilot-main injection for common rail system

Journal of Mechanical Science and Technology - Common rail system is a key technology of energy saving and emission reduction for modern diesel engines. Multiple injection, as one of the most...     

维吾尔、哈萨克文图文电视演播软件的研制

介绍了实现标准广播电视制式的７６８×５７６ ２５６ ｂｉｔ隔行扫描全屏显示的维吾尔和哈萨克文电视图文演播软件的研制方法,针对维吾尔和哈萨克文字的书写特点研究了自动选形和连写处理等几个关键编程技术。     

双笼翻板施工升降机进楼层存在问题案例分析

施工升降机的布置是一项技术性较强的工作,吊笼进入楼层的方式有是否使用脚手架平台之异。以某住宅项目为例,分析了双笼翻板施工升降机构造与外脚手架类型、建筑物平面与立面造型、施工进度动态管理等方面遇到的问题,提出了缩短附着架长度、调整外脚手架杆件、变更施工方式等解决方案,为今后类似条件下的施工提供借鉴参考。     

Roles and Applications of Red Blood Cell-Derived Extracellular Vesicles in Health and Diseases

Red blood cell-derived extracellular vesicles (RBCEVs) are vesicles naturally produced by red blood cells and play multiple roles such as acting as cell-to-cell communication messengers in both normal physiological and diseased states. RBCEVs are highly promising delivery vehicles for therapeutic agents such as biomolecules and nucleic acids as they are easy to source, safe, and versatile. RBCEVs autonomously target the liver and pass the blood–brain barrier into the brain, which is highly valuable for the treatment of liver and brain diseases. RBCEVs can be modified by various functional units, including various functional molecules and nanoparticles, to improve their active targeting capabilities for tumors or other sites. Moreover, the RBCEV level is significantly shifted in many diseased states; hence, they can also serve as important biomarkers for disease diagnoses. It is clear that RBCEVs have considerable potential in multiple medical applications. In this review, we briefly introduce the biological roles of RBCEVs, presented interesting advances in RBCEV applications, and discuss several challenges that need to be addressed for their clinical translation.     

Terahertz Direct Modulation Techniques for High-speed Communication Systems

Terahertz communication technology can provide abundant frequency resources,strong confidentiality,antijamming capability,communication tracking capability and ...