液相可控沉淀技术制备纳微结构药物颗粒

纳米药物作为纳米技术与医药技术的重要组成部分,受到了全世界学术界和产业界的重视。药物纳米化工程及应用是研究的热点问题。本文总结了液相沉淀法制备纳微结构药物颗粒的基本原理和方法,综述了近年来本课题组在药物构型的密度泛函计算以及液相沉淀法制备纳微结构药物颗粒方面的学术和产业化成果。针对不同药物体系的特性,提出了采用反溶剂沉淀法、反应沉淀法、反溶剂与反应耦合沉淀法以及分子自组装沉淀法等来制备纳微结构药物颗粒,阐述了超重力可控沉淀技术在制备纳微结构药物颗粒方面的工业化应用前景。     

Direct-chilling casting of Mg alloy under electromagnetic and ultrasonic combined field

The effects of low frequency electromagnetic (LFEC) field and ultrasonic (US) field on the microstructures, macrosegregation of alloying elements and the mechanical properties of DC cast AZ80 alloy were studied. The results show that both LFEC and US fields can refine the grains of the billets, which results in the increase in mechanical properties and uniformity of alloying element distribution. The effective refinement takes place on the edge of ingots when LFEC field is applied, while in the center of billets when field US is adopted. Combined the characteristics of LFEC and US fields, a new process for direct-chilling (DC) casting of Mg-electromagnetic-ultrasonic (ECUS) casting is developed, by which the grains are refined significantly and are more uniform in the whole ingots, and the mechanical properties of the ingots are improved.     

基于流程驱动的领域知识主动推送研究

针对需要的员工主动推送合适的知识可以提高企业员工获取知识的效率,促进企业知识应用与创新.从知识属性、流程、领域三个维度对企业知识进行了描述;在此基础上构建了面向流程的领域知识主动推送架构,提出了流程驱动的领域知识主动推送方式.根据知识推送系统的架构分析了员工、领域,知识、流程、子流程的概念及其数据结构,探讨了推送知识的匹配方法.以注塑机企业的知识推送平台为例,实现了基于流程驱动的领域知识主动推送系统.     

Isotropic high-resolution three-dimensional confocal micro-rotation imaging for non-adherent living cells

Recently, micro-rotation confocal microscopy has enabled the acquisition of a sequence of micro-rotated images of nonadherent living cells obtained during a partially controlled rotation movement of the cell through the focal plane. Although we are now able to estimate the three-dimensional position of every optical section with respect to the cell frame, the reconstruction of the cell from the positioned micro-rotated images remains a last task that this paper addresses. This is not strictly an interpolation problem since a micro-rotated image is a convoluted two-dimensional map of a three-dimensional reality. It is rather a 'reconstruction from projection' problem where the term projection is associated to the PSF of the deconvolution process. Micro-rotation microscopy has a specific difficulty. It does not yield a complete coverage of the volume. In this paper, experiments illustrate the ability of the classical EM algorithm to deconvolve efficiently cell volume despite of the incomplete coverage. This cell reconstruction method is compared to a kernel-based method of interpolation, which does not take account explicitly the point-spread-function (PSF). It is also compared to the standard volume obtained from a conventional z-stack. Our results suggest that deconvolution of micro-rotation image series opens some exciting new avenues for further analysis, ultimately laying the way towards establishing an enhanced resolution 3D light microscopy.     

基于C#.Net的数据库管理系统开发

针对图书资料管理信息化的需要,在Microsoft.net平台上结合C#语言的特点和.net技术,构建单机模式下的Windows Form图书管理系统,以及在ASP.NET中使用C#构建B/S模式的Web Form平台。通过该系统的投入使用和正常运行,体现出C#.Net开发信息管理系统的强大优势,以及信息管理系统的优越性能。     

Laparoscopic distal resection of the pancreas with the preservation of the spleen

Management of the pancreatic diseases is still a challenge to the laparoscopic technique. Some experience has been gained in the laparoscopic exploration of the pancreas and staging in cancer. Anatomically the accessibility of the distal pancreas provides the laparoscopic approach technically feasible. Patient and method: A case of insuloma in the tail of the pancreas is presented, where distal pancreatic resection was performed laparoscopically with the preservation of the spleen. In a 55 years old female patient with typical clinical symptoms of hyperinsulinism CT identified a 3 cm large solid tumor in the tail of the pancreas. Complete mobilization of the distal pancreas was enhanced by the use of an ultrasonic dissector (UltraCision). The pancreas is detached from the splenic hilum after dividing the spleen vessels. The pancreas is transected proximally by laparoscopic linear stapler. Preservation of the short gastric vessels provides the necessary blood supply of the spleen following division of the splenic artery and vein. Thus removal of the spleen is not a necessary step in this procedure. The operation was carried out within 4.5 hours. Postoperative course was uneventful, the patient left the hospital on the 5th postoperative day. Advantages of the procedure were the earlier mobilization and shorter recovery time, less postoperative pain. The procedure can be safely performed with a good experience in both pancreatic and laparoscopic surgery.     

基于Matlab的可编程逻辑微机保护的研究

目前在低压微机保护装置中,基于可编程逻辑的微机保护的应用是越来越多。这种微机保护平台,提高了微机保护装置的可靠性、灵活性、实用性、可扩展性和可移植性,大大缩短了产品的开发周期,同时有效解决了微机保护装置的工程化问题。在分析了目前常见的可编程逻辑微机保护之后,提出了一种新的基于Matlab/Simulink工具软件和DSP相结合的可编程逻辑微机保护的设想,这种方法预期有更高的灵活性,更短的产品开发周期。     

模拟酶解大豆7S、11S蛋白及其抗氧化活性的研究

以"活性肽搜寻与蛋白模拟水解系统"为工具,选择碱性蛋白酶和中性蛋白酶对大豆7S、11S蛋白进行模拟水解,得到不同水平的抗氧化肽肽段,以重均分子量为手段,评价理论模拟与实验水解的相关性;以还原力、清除二苯代苦味酰基苯肼(DPPH·)自由基能力比较以上蛋白酶水解物的抗氧化活性.结果表明:模拟与实验水解得到的分子量分布在比例以及重均分子量方面有显著相关性(P<0.01);四种酶解产物均具有一定的抗氧化活性,其中,以7S蛋白的碱性蛋白酶产物表现出最高的还原力和DPPH·清除能力(P<0.05).     

对公务员招聘问题的思考

本文利用层次分析法和0-1型整数规划建立了一个公务员招聘的数学模型,并结合实际提出了通用可行的算法。首先利用层次分析法确定了招聘人员面试成绩对用人部门的权重,再把笔试成绩转化为相应的权重,然后将笔试成绩和面试成绩对用人部门的权重结合起来,建立了权重计算模型。再把应聘人员的志愿转化为用人单位对应聘人员的权重,建立了双向选择的权重计算模型。然后确定最优方案模型,被选人员对用人单位的权重之和最大时的人员选取即为所求,从而建立了应聘人员最优选取的0-1整数规划模型,制定出最优的分配方案,并对一般情况即N个应聘人员M个用人单位时,对模型做了推广。最后利用Matlab和Lingo编程对上述模型和算法进行了实践求解。针对实际本文还充分考虑了多种情况下各种因素对人员招聘的影响,较完满地解决了公务员招聘问题,并检验了模型的合理性,文章分析了模型的优缺点和改进方向,同时提出了一些实用性建议。     

强脉冲离子束材料表面改性研究进展

强脉冲离子束材料表面改性技术是正在发展中的新的材料表面改性技术。近四、五年来,我们围绕发展强脉冲离子束材料表面改性技术对其主要机制(强脉冲能量效应)、离子辐照诱发的热力学过程、表面熔坑现象及大面积均匀离子束技术开展了比较全面的基础性研究。研究表明,强脉冲离子束改性除了离子注入的元素掺杂效应外,其更可利用强脉冲能量沉积诱发的热力学效应,有望突破离子射程对改性层厚度的限制,并高效利用离子剂量和能量,成为新一代低成本、高效率、高生产率、实用化的离子束材料改性与合成工艺。本文对于上述研究的主要进展和相关问题进行了总结和评论。