聚四氢呋喃生产工艺评述

综述了工业化的聚四氢呋喃(PTMEG)传统生产工艺,重点介绍了美国杜邦和日本旭化成公司的新工艺和新催化剂,比传统工艺投资少且环境友好.概述了国内研究开发现状,建议国内尽快建立采用新工艺的大型PTMEG工业化生产装置.     

AS 1.398中性蛋白酶制备水解明胶(Ⅲ)——固定化酶的稳定性研究

以壳聚糖为载体 ,戊二醛为交联剂制得的固定化AS 1 398中性蛋白酶。对其pH稳定性、热稳定性和操作稳定性进行了研究。其结果表明 ,酶被固定化后 ,上述稳定性有明显提高     

AS 1.398中性蛋白酶制备水解明较(Ⅳ)——固定化酶制备水解明胶的应用研究

本文研究了反应时间、温度、pH和酶量对固定化AS 1 398中性蛋白酶催化明胶水解反应过程的影响 ,讨论了固定化AS 1 398中性蛋白酶促明胶水解制备水解明胶的可能性     

Electrical conductivity and electromagnetic interference shielding effectiveness of carbon black/sisal fiber/polyamide/polypropylene composites

The effects of hybrid fillers on the electrical conductivity and electromagnetic interference (EMI) shielding effectiveness (SE) of polyamide 6 (PA6)/polypropylene (PP) immiscible polymer blends were investigated. Carbon black (CB) and steam exploded sisal fiber (SF) were used as fillers. CB was coated on the surface of SF, and this was exploded by water steam to form carbon black modified sisal fiber (CBMSF). CB/SF/PA6/PP composites were prepared by melt compounding, and its electromagnetic SE was tested in low‐frequency and high‐frequency ranges. We observed that SF greatly contributed to the effective decrease in the percolation threshold of CB in the PA6/PP matrix and adsorbed carbon particles to form a conductive network. Furthermore, an appropriate CB/SF ratio was important for achieving the best shielding performance. The results indicate that CBMSF was suitable for use as electronic conductive fillers and the CB/SF/PA6/PP composites could be used for the purpose of EMI shielding. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 42801.     

磷化镍的制备及其催化糠醛加氢制备环戊酮

以NiCl_2·6H_2O为镍源、NaH_2PO_2·H_2O为磷源、乙二醇为溶剂、n(P)∶n(Ni)=3∶1,采用溶剂热法制备得到磷化镍(Ni-P)催化剂,并采用XRD、SEM、TEM、H_2-TPR、H_2-TPD、N_2吸附-脱附、XPS对其进行了表征。催化剂应用于糠醛加氢制备环戊酮的反应中效果良好,并考察了催化剂用量、氢气压力、反应温度、反应时间对反应的影响。结果表明,较优的工艺条件为:以水作为溶剂,原料与催化剂质量比为12,在反应温度150℃、氢气压力2.0 MPa、反应时间4 h时,糠醛转化率达到98.87%,环戊酮收率为68.65%。对催化剂进行稳定性测试,4次重复使用后环戊酮收率仅下降3.25%。     

Synthesis and biological activities of a 3'-azido analogue of Doxorubicin against drug-resistant cancer cells

Doxorubicin (DOX), an anthracycline antibiotic, is one of the most active anticancer chemotherapeutic agents. The clinical use of DOX, however, is limited by the dose-dependant P-glycoprotein (P-gp)-mediated resistance. Herein, a 3'-azido analogue of DOX (ADOX) was prepared from daunorubicin (DNR). ADOX exhibited potent antitumor activities in drug-sensitive (MCF-7 and K562) and drug-resistant cell lines (MCF-7/DNR, K562/DOX), respectively. The drug resistance index (DRI) values of ADOX were much lower than that of DOX. The cytotoxicity experiments of ADOX or DOX against K562/DOX, with or without P-gp inhibitor, indicated that ADOX circumvents resistance by abolishing the P-gp recognition. This conclusion was further supported by drug influx/efflux flow cytometry experiments, as well as by molecular docking of ADOX to P-gp. In vivo animal tests, ADOX exhibited higher activity and less toxicity than DOX. The current data warranted ADOX for additional pre-clinical evaluations for new drug development.     

增效吡虫啉对豆蚜的室内毒力测定

[目的]测定增效吡虫啉对豆蚜的毒力。[方法]采用浸渍法测定了2种增效吡虫啉对豆蚜的24 h致死作用,同时以市售的35%吡虫啉悬浮剂为对照。[结果]31%增效吡虫啉悬浮剂SE-6-4防治豆蚜的效果最佳,其LC50值为5.2673 mg/L;其次为31%增效吡虫啉悬浮剂SE-1,LC50值为7.7441 mg/L;35%吡虫啉悬浮剂的LC50值为10.5630 mg/L,豆蚜对其的敏感性相对较低。[结论]31%增效吡虫啉悬浮剂SE-6-4和SE-1是2个良好的制剂产品,具有减量同效的应用价值,可将其进一步用于田间试验。     

大学生课外科技活动的探索与实践

结合本校化学化工类专业大学生课外科技活动实际,分析了学年论文写作、社团活动、举办学科竞赛、开放实验室等大学生课外科技活动的改革实践,讨论了大学生课外科技活动内容、模式、方法改革的主要措施。实践表明,课外科技实践活动培养和锻炼了大学生的团结协作能力、团队精神和良好的世界观,提升了学生在创业就业中的竞争力。     

多环麝香的分子结构和香气关系的研究

本文论述了多环麝香的近期进展,提出了分类的原则和系统的分类方法。研究和总结了茚满型、萘满型、色满酮型、异色满型、氢化引达省型、苊型等各种多环麝香化合物的分子结构与香气的关系。     

R-(+)-α-硫辛酸的合成工艺

以6,8-二氯辛酸为原料,S-(-)-α-苯乙胺为拆分剂进行拆分反应得到R-(+)-6,8-二氯辛酸;经酯化制得R-(+)-6,8-二氯辛酸乙酯;后经硫化水解一步合成R-(+)-α-硫辛酸。考察了投料比、溶剂、催化剂、温度等条件对产物收率、比旋光度的影响。结果表明:拆分反应较佳条件为n[S-(-)-α-苯乙胺]∶n(6,8-二氯辛酸)=0.45∶1,溶剂为乙酸乙酯;酯化反应较佳条件为催化剂为对甲苯磺酸,反应时间7 h;硫化反应较佳条件为温度为65℃;相转移催化剂用量0.4 g,总收率为44.3%。通过红外光谱、比旋光度、核磁共振等对产物和中间产物进行了表征。