Influence of layer charge on swelling of smectites

Six separate processes control the swelling of smectites saturated with alkali and alkaline earth cations in aqueous systems. The basic mechanism and forces controlling each of the processes are different. Crystalline swelling occurs between smectite layers within quasicrystals and involves the intercalation of zero to four discrete layers of water molecules. A balance between strong electrostatic-attraction and hydration-repulsion forces controls crystalline swelling. The extent of crystalline swelling decreases with increasing layer charge. Double-layer swelling occurs between quasicrystals. An electrostatic repulsion force develops when the positively charged diffuse portions of double layers from two quasicrystals overlap in an aqueous suspension. Layer charge has little or no direct effect on double-layer swelling. The break up and formation of quasicrystals is a dynamic process that controls the average size of quasicrystals in an aqueous smectite suspension. As layer charge increases, quasicrystals tend to become larger and more stable. In smectite suspensions with more than one type of exchangeable cation, the cations can demix (e.g., Na and Ca may be segregated in different interlayer regions) due to a complex feed-back between cation exchange selectivity and crystalline swelling. Demixing influences the breakup and formation of quasicrystals because quasicrystals preferentially cleave along interlayers dominated by alkali cations. Increasing layer charge increases selectivity for alkaline earth cations relative to Na or Li, and hence reduces the breakup of quasicrystals. Co-volume swelling is an entropy driven process caused by restrictions on the rotational freedom of suspended quasicrystals. Brownian swelling is also an entropy driven process resulting from random thermal motion of suspended colloids. There is no reason to believe that layer charge directly influences either co-volume or Brownian swelling. Macroscopic measures of swelling (e.g., change in total volume or water content) necessarily measure the combined effect of all swelling processes occurring within the system.     

Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase

The cytosine analog 5-aza-2'-deoxycytidine has been used clinically to reactivate genes silenced by DNA methylation. In particular, patients with beta-thalassemia show fetal globin expression after administration of this hypomethylating drug. In addition, silencing of tumor suppressor gene expression by aberrant DNA methylation in tumor cells may potentially be reversed by a similar regimen. Consistent with its function in maintaining tumor suppressor gene expression, 5-aza-2'-deoxycytidine significantly reduces intestinal tumor multiplicity in the predisposed Min mouse strain. Despite its utility as an anti-cancer agent, the drug is highly mutagenic by an unknown mechanism. To gain insight into how 5-aza-2'-deoxycytidine induces mutations in vivo, we examined the mutational spectrum in an Escherichia coli lac I transgene in colonic DNA from 5-aza-2'-deoxycytidine-treated mice. Mutations induced by 5-aza-2'-deoxycytidine were predominantly at CpG dinucleotides, which implicates DNA methyltransferase in the mutagenic mechanism. C:G-->G:C transversions were the predominant class of mutations observed. We suggest a model for how the mammalian DNA methyltransferase may be involved in facilitating these mutations. The observation that 5-aza-2'-deoxycytidine-induced mutations are mediated by the enzyme suggests that novel inhibitors of DNA methyltransferase, which can inactivate the enzyme before its interaction with DNA, are needed for chemoprevention or long term therapy.     

Mechanical behaviour of a cross-weave ceramic matrix composite

The deformation and fracture processes of a cross-weave carbon fibre/SiC composite prepared by a chemical vapour deposition process has been explored by interrupted-loading tests and SEM examination of cracking and fracture processes. The tensile stress-strain curves show non-linear behaviour associated with progressive matrix cracking and spalling, and the occasional fracture of a fibre. Re-loading curves and compressive stress-strain curves show linear behaviour. The fracture process does not involve cracking by a single dominant crack but occurs by the development of multiple damage sites operating around the transverse fractures of groups of four to eight fibres followed by longitudinal cracking at their fibre-matrix interfaces and temporary arrest of the cracks, until specimen failure occurs and there is massive fibre debonding and pull-out.     

越来越小的射频导电衬垫

随着使用射频导电衬垫屏蔽体的体积越来越小,这些导电衬垫相应地也小了许多.在漫长的电子史上,曾经用在电弧激发的电磁波室内壁装贴防电磁泄漏金属板的方法来构建屏蔽室.     

A “PAC” Algorithm for Making Feature Maps

Kohonen and others have devised network algorithms for computing so-calledtopological feature maps. We describe a new algorithm, called theCDF-Inversion (CDFI) Algorithm, that can be used to learn feature maps and, in the process, approximate an unknown probalility distribution to within any specified accuracy. The primary advantags of the algorithm over previous feature-map algorithms are that it is simple enough to analyze mathematically for correctness and efficiency, and that it distributes the points of the map evenly, in a sense that can be made rigorous. Like other vector-quantization algorithms it is potentially useful for many applications, including monitoring and statistical modeling. While not a network algorithm, the CDFI algorithm is well-suited to implementation on parallel computers.Sterling Federal Systems, Inc.NASA Ames Research Center     

A symbolic solution to intelligent real-time control

Autonomous systems must operate in dynamic, unpredictable environments in real time. The task of flying a plane is an example of an environment in which the agent must respond quickly to unexpected events while pursuing goals at different levels of complexity and granularity. We present a system, Air-Soar, that achieves intelligent control through fully symbolic reasoning in a hierarchy of simultaneously active problem spaces. Achievement goals, changing to a new state, and homeostatic goals, continuously maintaining a constraint, are smoothly integrated within the system. The hierarchical approach and support for multiple, simultaneous goals give rise to multi-level reactive behavior, in which Air-Soar responds to unexpected events at the same granularity where they are first sensed.     

Human exposure assessment: a case study of 8 PAH contaminated soils using in vitro digestors and the juvenile swine model

In vitro digestors can be used to provide bioaccessibility values to help assess the risk from incidental human ingestion of contaminated soils. It has been suggested that these digestors may need to include a lipid sink to mimic human uptake processes. We compare the correspondence between in vivo polycyclic aromatic hydrocarbon (PAH) uptake for eight different PAH contaminated soils with PAH release in in vitro digestors in the presence and absence of a lipid sink. Lipid sinks were essential to the success of the in vitro digestors in predicting juvenile swine PAH uptake. In the presence of the lipid sink, results of the In Vitro Digestion model (IVD) closely corresponded with a slope of 0.85 (r(2) = 0.45, P < 0.07) to the in vivo results. The Relative Bioaccessibility Leaching Procedure (RBALP) results did not correspond to the in vivo study but did tightly reflect total soil PAH concentration. We conclude that the basis of this difference between digestors is that the RBALP used an aggressive extraction technique that maximized PAH release from soil. Systemic uptake in juvenile swine was not linked to soil PAH concentration but rather to the thermodynamic properties of the soil.     

A round robin study of flexible large-area roll-to-roll processed polymer solar cell modules

A round robin for the performance of roll-to-roll coated flexible large-area polymer solar-cell modules involving 18 different laboratories in Northern America, Europe and Middle East is presented. The study involved the performance measurement of the devices at one location (Risø DTU) followed by transportation to a participating laboratory for performance measurement and return to the starting location (Risø DTU) for re-measurement of the performance. It was found possible to package polymer solar-cell modules using a flexible plastic barrier material in such a manner that degradation of the devices played a relatively small role in the experiment that has taken place over 4 months. The method of transportation followed both air-mail and surface-mail paths.