面向服务的中间件管理方法

中间件的繁荣使得中间件的管理面临着管理对象的类型与数量都极大丰富的问题;同时,开放的网络环境使得管理目标呈现出多样化、综合化和柔性化的特点。上述问题要求中间件的管理能力具有可增长的特性,以满足个性、多样的管理需求。提出了一种面向服务的中间件管理方法。方法中,已有的中间件管理功能被封装为服务,通过服务组装的方式实现管理功能的增值。讨论了中间件预置管理功能的封装、管理的组装模式、组装中接口适配和异常处理等问题,并用一个J2EE场景的管理实例示范和论证了提出的方法。     

Finite element analysis of a laser-processed fracture specimen

Finite element analysis was used to simulate the static failure of a AISI 4140, three-point bend, Charpy specimen. Non-linear finite element models (FEM) were constructed to represent standard Charpy, fatigue-precracked Charpy, and laser-processed Charpy specimens. For the laser-processed Charpy FEM, a strain-based failure criterion was used to simulate crack propagation through the 0.5 mm thick laser-processed zone. For comparison, a 0.5 mm long crack was used in the fatigue-precracked FEM and similarly loaded. Results showed that the numerically calculated load for crack initation through this zone compared favorably to that reported in earlier experiments. Furthermore, after the crack had propagated through the laser-processed zone within the FEM-comparison of plastic strain contours for this model and that for a fatigue-precracked model showed that similar patterns exist around the crack tip. These results indicate that laser-processing and fatigue-precracking should provide a similar basis for fracture toughness measurements.     

Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide

BACKGROUND: Recruitment of the intracellular tyrosine kinase Syk to activated immune-response receptors is a critical early step in intracellular signaling. In mast cells, Syk specifically associates with doubly phosphorylated immunoreceptor tyrosine-based activation motifs (ITAMs) that are found within the IgE receptor. The mechanism by which Syk recognizes these motifs is not fully understood. Both Syk SH2 (Src homology 2) domains are required for high-affinity binding to these motifs, but the C-terminal SH2 domain (Syk-C) can function independently and can bind, in isolation, to the tyrosine-phosphorylated IgE receptor in vitro. In order to improve understanding of the cellular function of Syk, we have determined the solution structure of Syk-C complexed with a phosphotyrosine peptide derived from the gamma subunit of the IgE receptor. RESULTS: The Syk-C:peptide structure is compared with liganded structures of both the SH2 domain of Src and the C-terminal SH2 domain of ZAP-70 (the 70 kDa zeta-associated protein). The topologies of these domains are similar, although significant differences occur in the loop regions. In the Syk-C structure, the phosphotyrosine and leucine residues of the peptide ligand interact with pockets on the protein, and the intervening residues are extended. CONCLUSIONS: Syk-C resembles other SH2 domains in its peptide-binding interactions and overall topology, a result that is consistent with its ability to function as an independent SH2 domain in vitro. This result suggests that Syk-C plays a unique role in the intact Syk protein. The determinants of the binding affinity and selectivity of Syk-C may reside in the least-conserved structural elements that comprise the phosphotyrosine- and leucine-binding sites. These structural features can be exploited for the design of Syk-selective SH2 antagonists for the treatment of allergic disorders and asthma.     

Effective health and safety management

Since the introduction of COSHH, textile manufacturers have energetically set up new health and safety policies. But how much of this has been relevant? John Laird looks at the progress made so far and calls for better health and safety management in the future.     

ViewPoint为远程图像监控提供全面解决方案

本文较详细地介绍了华为公司自行开发生产的远程图像监控系统ＶｉｅｗｏＰｏｉｎｔ的组网方式，系统结构以及为客户提供的几种典型的需求及解决方案。     

Emotion-specific effects of facial expressions and postures on emotional experience.

A total of 74 Ss were induced to adopt expressions of fear, anger, disgust, and sadness in Experiment 1. Each expression significantly increased feelings of its particular emotion compared with at least two of the others, a result that cannot be explained by a single dimension. Postures should play the same role in emotional experience as facial expressions. However, the demonstrated effects of postures (Riskind, 1984) could also represent a single dimension of variation. In Experiment 2, subjects were induced to adopt postures characteristic of fear, anger, and sadness. Again, the effects were specific to the postures. These two studies indicate that emotional behavior produces changes in feelings that specifically match the behavior. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

结晶状态对铜内耗频率谱的影响

用内耗频率谱仪测量了多晶铜、纳米晶铜和单晶铜试样的内耗频率谱，在170，320以及490Hz附近观测到3个明显的共振吸收频率峰，3种试样在晶粒结构上存在极大差别，但其共振吸收内耗峰出现在相同频率范围，这说明产生内耗频率峰的机制与晶体缺陷和晶粒尺度无关，而与材料的晶体点阵性质密切相关。