The privileged sensing framework: A principled approach to improved human-autonomy integration

ABSTRACT

A primary goal for human-autonomy integration (HAI) is to balance the strengths of human and autonomy in order to achieve performance objectives more efficiently and robustly than either the human or autonomous agents would independently. This paper proposes the Privileged Sensing Framework (PSF) as a novel approach to HAI. This approach is based on the concept of dynamically ‘privileging’ information during the process of integration by dynamically bestowing special rights based on the characteristics of each individual agent, the task context, and the performance goals. The proposed framework is tested through a series of simulation experiments that provide a clear demonstration of increased accuracy and throughput of human-autonomy performance. These proof-of-concept simulations provide initial evidence of the utility of the PSF. Continued development of this approach has the potential to revolutionise capabilities of multi-agent cooperative teams across a broad range of applications.     

Isomorphic Pressures, Peripheral Product Attributes and Emerging Market Firm Export Performance

• Drawing upon the neo-institutional theory of mimetic isomorphism and the concept of the extended product, we identify and empirically evaluate two potential product strategies that emerging market firms (EMFs) may use to improve their export performance while also addressing the financial, managerial expertise, and international experience limitations that they frequently face.
• Hierarchical regression is used to test our proposed peripheral product adaptation strategies on a unique dataset of 106 Chinese and Romanian exporters.
• We find that EMFs that change either of two visible peripheral product attributes (the brand name or the packaging) to conform to local market norms, on average, are more satisfied with their export performance than those that pursue other strategies. Our results also suggest that changing the brand name to conform to local market norms has more than twice the impact on EMF performance than does changing the packaging.
• Consistent with the tenets of neo-institutional theory, EMFs managers may be able to improve their firms’ export performance by changing the peripheral attributes of their products to conform to local market norms.

     

Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A

Targeting sites that modulate protein-protein interactions represents an ongoing challenge for drug discovery. We have devised an assay principle, named ligand-regulated competition (LiReC), in an effort to find non-ATP competitive small-molecule regulators for type Ialpha cAMP-dependent Protein kinase (PKA-Ialpha), a protein complex that is implicated in disease. Our assay based on the LiReC principle utilizes a competitive fluorescent peptide probe to assess the integrity of the PKA-Ialpha complex upon introduction of an allosteric ligand. The developed fluorescence polarization method screens for small molecules that specifically protect (antagonists) or conversely activate (agonists) this protein complex. In high-throughput format, various cyclic nucleotide-derived agonists and antagonists are successfully detected with high precision. Furthermore, assay performance (Z'-factors above 0.7) far exceeds the minimum requirement for small-molecule screening. To identify compounds that operate through novel modes of action, our method shields the ATP-binding site and purposely excludes ATP-competitive ligands. These proof-of-principle experiments highlight the potential of the LiReC technique and suggest its application to other protein complexes, thereby providing a novel approach to identify and characterize modulators (small molecules, proteins, peptides, or nucleic acids) of protein-protein systems.     

Examination of the relationship between true halo and halo error in performance ratings.

The purpose of this study was to test competing theories regarding the relationship between true halo (actual dimensional correlations) and halo rater error (effects of raters' general impressions on specific ratee qualities) at both the individual and group level of analysis. Consistent with the prevailing general impression model of halo rater error, results at both the individual and group level analyses indicated a null (vs. positive or negative) true halo-halo rater error relationship. Results support the ideas that (a) the influence of raters' general impressions is homogeneous across rating dimensions despite wide variability in levels of true halo; (b) in assigning ratings, raters rely both on recalled observations of actual ratee behaviors and on general impressions of ratees in assigning dimensional ratings; and (c) these 2 processes occur independently of one another. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Modeling Suspended Sediment during Construction in Great Barrier Reef World Heritage Area

A marina was constructed in the Great Barrier Reef World Heritage Area in close proximity to coral reefs that could be damaged by excess turbidity generated during construction. Since there was uncertainty about both the fate of suspended sediments and their effect on corals, initial water quality constraints were set very conservatively. In order to better understand the movement of suspended sediment during construction, a numerical model study was commissioned using three-dimensional, numerical, hydrodynamic, and Lagrangian particle tracking models. The study was successful in: (1) increasing the understanding of and reducing the uncertainty of sediment dispersal patterns under a range of common forcing conditions; (2) testing the variation in suspended sediment concentrations over sensitive areas for two different outfall locations; (3) offering evidence that a good choice in outfall locations will reduce the threat to corals; and importantly (4) presenting the results in a way that enhanced understanding by nontechnical reef managers. This final result was achieved by creating movies of sediment movement that clearly demonstrated the complex hydrodynamic processes involved with near-coastal water currents. Specific model results showed: (1) that a more seaward outfall increases effluent dispersal away from sensitive areas; (2) the highest concentrations of effluent over sensitive sites occur during no wind and neap tide conditions; and (3) prevailing southeast winds advect effluent offshore, away from sensitive sites.     

HIV-AIDS Patients' Evaluation of Health Information on the Internet: The Digital Divide and Vulnerability to Fraudulent Claims.

Access to health information on the Internet has revolutionized how medical patients learn about their illnesses. Valuable information can be found online; however, many health Web sites contain inaccurate or misleading information. The authors surveyed 324 adults with HIV concerning their Internet use for obtaining health information. Health information found online was then rated for quality by participants and by medical professionals. Participants were less critical of health information found online than medical professionals and made smaller distinctions between high-quality and low-quality information. Assigning credibility to low-quality information was predicted by lower incomes and educational attainment, poorer reading comprehension, lower literacy levels, and irrational health beliefs. Results suggest that patients do not always evaluate online information critically and may be vulnerable to misinformation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Overt and Relational Aggression and Perceived Popularity: Developmental Differences in Concurrent and Prospective Relations.

Relations of overt and relational aggression with perceived popularity among children and early adolescents were examined in 2 studies (Ns = 607 and 1,049). Among older youths, positive concurrent relations found between overt aggression and perceived popularity became nonsignificant when relational aggression was controlled, whereas positive associations found between relational aggression and perceived popularity held when overt aggression was controlled. Aggression and perceived popularity were not positively related for the younger participants. The 2nd study also examined the temporal ordering of these relations over 6 months. For older girls, positive relations between relational aggression and perceived popularity were bidirectional. For older boys, relational aggression did not predict increased perceived popularity, but perceived popularity predicted increased relational aggression. Implications for intervention are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Colorectal cancer detection and screening

Colon cancer is a leading cause of death in the United States and is estimated to cause 56,500 deaths during 1998. Most cancers evolve from adenomatous polyps. Screening asymptomatic average-risk individuals is recommended to reduce colorectal cancer mortality by detection and removal of adenomatous polyps.     

Pretreatment predictors of dropout from cognitive behavioral therapy for PTSD in Iraq and Afghanistan war veterans.

Cognitive–behavioral therapies (CBTs) can be effective treatments for posttraumatic stress disorder (PTSD) but their effectiveness is limited by high rates of premature dropout. Few studies have compared pretreatment characteristics of treatment completers and dropouts, and only one has examined these factors in Operations Iraqi Freedom and Enduring Freedom (OIF/OEF) Veterans. This study analyzed archival clinical data from 117 OEF/OIF Veterans evaluated and treated through a Veterans Affairs PTSD clinic. High numbers dropped out of treatment (68%). Treatment dropouts (n = 79) and completers (n = 38) differed significantly on Minnesota Multiphasic Personality Inventory-2 (MMPI-2) scales, PTSD symptom severity, and age. Regression analyses identified one MMPI-2 scale, TRT (negative treatment indicators), and age as unique but modest predictors of dropout. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Relationship of cocaine-induced c-Fos expression to behaviors and the role of serotonin 5-HT2A receptors in cocaine-induced c-Fos expression.

Serotonin 5-HT2A receptor antagonists have been shown to attenuate the locomotor stimulant effects of cocaine in rats. The present study used the expression of c-Fos protein as a marker to identify brain areas through which 5-HT2A receptors may modulate cocaine-induced behaviors. Significant correlations were observed between cocaine-induced hyperactivity and c-Fos expression in the nucleus accumbens core (NAcC), caudate-putamen (CPu), and subthalamic nucleus. In a separate experiment, a low, behaviorally relevant dose of cocaine was found to increase c-Fos immunoreactivity in the medial CPu, NAcC, and nucleus accumbens shell (NAcSh). The selective 5-HT2A receptor antagonist M100907 significantly attenuated cocaine-induced c-Fos expression in the medial CPu and in the NAcSh. These data suggest that 5-HT2A receptors in the NAcSh and CPu or in afferents to these regions may contribute to genomic responses to cocaine in the brain as well as to cocaine-induced locomotor activity. (PsycINFO Database Record (c) 2010 APA, all rights reserved)