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101.
Renato Martins da Silva Bárbara Della Noce Camila Fernanda Waltero Evenilton Pessoa Costa Leonardo Araujo de Abreu Naftaly Wang’ombe Githaka Jorge Moraes Helga Fernandes Gomes Satoru Konnai Itabajara da Silva Vaz Jr. Kazuhiko Ohashi Carlos Logullo 《International journal of molecular sciences》2015,16(1):1821-1839
102.
Cinzia Ciccacci Sara Rufini Sandro Mancinelli Ersilia Buonomo Emiliano Giardina Paola Scarcella Maria C. Marazzi Giuseppe Novelli Leonardo Palombi Paola Borgiani 《International journal of molecular sciences》2015,16(3):5830-5838
Steven–Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are severe adverse drug reactions, characterized by extensive epidermal detachment and erosions of mucous membrane. SJS/TEN is one of the most serious adverse reactions to Nevirapine (NVP) treatment, commonly used in developing countries as first-line treatment of human immunodeficiency virus infection. In the last years TRAF3IP2 gene variants had been described as associated with susceptibility to several diseases such as psoriasis and psoriatic arthritis. We hypothesized that this gene, involved in immune response and in NF-κB activation, could also be implicated in the SJS/TEN susceptibility. We performed a full resequencing of TRAF3IP2 gene in a population of patients treated with NVP. Twenty-seven patients with NVP-induced SJS/TEN and 78 controls, all from Mozambique, were enrolled. We identified eight exonic and three intronic already described variants. The case/control association analysis highlighted an association between the rs76228616 SNP in exon 2 and the SJS/TEN susceptibility. In particular, the variant allele (C) resulted significantly associated with a higher risk to develop SJS/TEN (p = 0.012 and OR = 3.65 (95% CI 1.33–10.01)). A multivariate analysis by logistic regression confirmed its significant contribution (p = 0.027, OR = 4.39 (95% CI 1.19–16.23)). In conclusion, our study suggests that a variant in TRAF3IP2 gene could be involved in susceptibility to SJS/TEN. 相似文献
103.
Numerous studies have been focused to natural ingredients to maintain the quality and shell life of foods. Edibles coating, biodegradable ingredients, such as hydrocolloids and proteins can be used for coating fish with the purpose to suppress changes of quality during frozen storage. At the present time several developing of edibles packing, like glaze using hydrocolloids, (gelatin, carrageen, starch), that besides acts as protective film for food, they are economic, can be ingested by the consumer without toxicity risk, help to preserve organoleptics and nutritional characteristics of the product and, being biodegradable they contribute to the conservation of the atmosphere. The objective of the present study was to evaluate the incorporation ofhydrocolloids in the glazing tuna process as alternative of packing, to enhance its physical and chemical characteristics. Samples of tuna was glazed incorporating to its solutions of carrageen at 0.05, 0,1 and 0.15%, and gelatin at 0.5, 1%. The samples were shaped as square (15 cm3), frozen al -30 degrees C and glazed incorporating hydrocolloids submerging the sample its solutions at 0 degrees C by 30 seconds and storage at -10 degrees C by 0, 15 and 30 days. Proximal analysis results, soluble proteins, TBA, and color showed that all the samples glazed with hydrocolloids decrease deterioration of the tuna products respect to samples glazed without hydrocolloids; concluding that glazing adding hydrocolloids protects tuna for loss humidity and delays degradation of proteins. Moreover, carrageen shows to a better performance at the concentrations of 0.05% compared with the gelatin and the starch. 相似文献
104.
James S. Bendall Marzia Paderi Francesca Ghigliotti Nello Li Pira Vitoguido Lambertini Vladimir Lesnyak Nikolai Gaponik Giuseppe Visimberga Alexander Eychmüller Clivia M. Sotomayor Torres Mark E. Welland Christina Gieck Leonardo Marchese 《Advanced functional materials》2010,20(19):3298-3302
A novel all‐inorganic electroluminescent device is demonstrated based on highly luminescent CdTe nanocrystals intercalated within a laminar hydrotalcite‐like structure. The laminar scaffold acts to both support and distribute the CdTe nanocrystals. The device is synthesized using simple wet chemical processes at room temperature in ambient conditions. It has high thermal stability, operating continuously up to 90 °C, and a maximum efficiency at J = 0.12 A cm?2. The device is targeted at the automotive industry. 相似文献
105.
106.
n-Heptane, 2- and 3-methylhexane, ethylcyclopentane, and cycloheptane were passed in the presence of hydrogen at 500 °C over “nonacidic” platinum-alumina catalyst containing 3% by weight of platinum. The conversion ranged between 12 and 26%, depending on the interval of time the product was removed for analysis. In the case of cycloheptane, however, the conversion amounted to 98% during the first 30 min on stream and with time, during the approximate period between 2 and 3 h, it decreased to 69%. The products from the reaction contained besides toluene, also hydrocarbons resulting from a skeletal isomerization and dehydrocyclization of the original hydrocarbons, and to a smaller extent from a bond shift process, and a repetitive 1,5-ring closure followed by hydrogenolysis. Using 1,1-dimethylcyclohexane as a model compound, it was shown that the skeletal isomerization accompanying the aromatization of the seven-carbon hydrocarbons does not proceed through cationic intermediates. A survey of the literature relating to the mechanism of aromatization of hydrocarbon over “nonacidic” chromia-alumina and platinum-alumina catalysts is presented, and the differences between the two mechanisms are discussed. 相似文献
107.
108.
We provide a discussion of bounded rationality learning behind traditional learning mechanisms, i.e., Recursive Ordinary Least Squares and Bayesian Learning . These mechanisms lack for many reasons a behavioral interpretation and, following the Simon criticism, they appear to be substantively rational. In this paper, analyzing the Cagan model, we explore two learning mechanisms which appear to be more plausible from a behavioral point of view and somehow procedurally rational: Least Mean Squares learning for linear models and Back Propagation for Artificial Neural Networks . The two algorithms look for a minimum of the variance of the error forecasting by means of a steepest descent gradient procedure. The analysis of the Cagan model shows an interesting result: non-convergence of learning to the Rational Expectations Equilibrium is not due to the restriction to linear learning devices; also Back Propagation learning for Artificial Neural Networks may fail to converge to the Rational Expectations Equilibrium of the model. 相似文献
109.
Leonardo Queiroz de Souza Ana Dolores Santiago de Freitas Everardo Valadares de Sá Barretto Sampaio Patrícia Maia Moura R?mulo Sim?es Cezar Menezes 《Nutrient Cycling in Agroecosystems》2012,94(2-3):171-179
Despite the recognized importance of the process, estimates of the amount of nitrogen fixed by biological symbiosis in tropical dry forests are almost nonexistent. We estimated the nitrogen fixed annually by the leaves of trees and shrubs at sites regenerating for 16 and 38?years and in an old-growth dry forest using 15N abundance methodology. The total leaf biomass (1,824?C3,036?kg?ha?1) and nitrogen contents (62?C90?kg?ha?1) did not differ among the areas. In all of the areas, most of the leaf biomass belonged to legume plants, but the proportion of the N2-fixing legumes decreased with increasing regeneration time. In the 16-year regenerating area, almost all of the N was in the leaves of the N-fixing Mimosa tenuiflora plants, but fixation was absent or very low as it was in the N-fixing species present in the 38-year regenerating area. In the old-growth Caatinga, all of the N-fixing species (M. tenuiflora, Piptadenia stipulacea and Anadenanthera colubrina) had large proportions (47?C62?%) of their N derived from atmospheric N2, but the amount of fixed N (6?kg?ha?1) was a small proportion of the total leaf N because these plant species were a small part of the vegetation. The total input of biologically fixed N to the old-growth forest was similar in magnitude to an estimate made for a humid tropical forest in Amazonia. 相似文献
110.
Weber Lukas Vinon Tobias Kndler Christian Solis-Vasquez Leonardo Bernhardt Arthur Petrov Ilia Koch Andreas 《Distributed and Parallel Databases》2022,40(1):27-45
Distributed and Parallel Databases - Massive data transfers in modern data-intensive systems resulting from low data-locality and data-to-code system design hurt their performance and scalability.... 相似文献