Guiding the evolution of product-line configurations

Software and Systems Modeling - A product line is an approach for systematically managing configuration options of customizable systems, usually by means of features. Products are generated for...     

Bias extension test for pantographic sheets: numerical simulations based on second gradient shear energies

We consider a bi-dimensional sheet consisting of two orthogonal families of inextensible fibres. Using the representation due to Rivlin and Pipkin for admissible placements, i.e. placements preserving the lengths of the inextensible fibres, we numerically simulate a standard bias extension test on the sheet, solving a non-linear constrained optimization problem. Several first and second gradient deformation energy models are considered, depending on the shear angle between the fibres and on its gradient, and the results obtained are compared. The proposed numerical simulations will be helpful in designing a systematic experimental campaign aimed at characterizing the internal energy for physical realizations of the ideal pantographic structure presented in this paper.     

Epigallocatechin Gallate Ameliorates the Effects of Prenatal Alcohol Exposure in a Fetal Alcohol Spectrum Disorder-Like Mouse Model

Fetal alcohol spectrum disorder is the main preventable cause of intellectual disability in the Western world. Although binge drinking is the most studied prenatal alcohol exposure pattern, other types of exposure, such as the Mediterranean, are common in specific geographic areas. In this study, we analyze the effects of prenatal alcohol exposure in binge and Mediterranean human drinking patterns on placenta and brain development in C57BL/6J mice. We also assess the impact of prenatal treatment with the epigallocatechin-3-gallate antioxidant in both groups. Study experimental groups for Mediterranean or binge patterns: (1) control; (2) ethanol; (3) ethanol + epigallocatechin-3-gallate. Brain and placental tissue were collected on gestational Day 19. The molecular pathways studied were fetal and placental growth, placental angiogenesis (VEGF-A, PLGF, VEGF-R), oxidative stress (Nrf2), and neurodevelopmental processes including maturation (NeuN, DCX), differentiation (GFAP) and neural plasticity (BDNF). Prenatal alcohol exposure resulted in fetal growth restriction and produced imbalances of placental angiogenic factors. Moreover, prenatal alcohol exposure increased oxidative stress and caused significant alterations in neuronal maturation and astrocyte differentiation. Epigallocatechin-3-gallate therapy ameliorated fetal growth restriction, attenuated alcohol-induced changes in placental angiogenic factors, and partially rescued neuronal nuclear antigen (NeuN), (doublecortin) DCX, and (glial fibrillary acidic protein) GFAP levels. Any alcohol consumption (Mediterranean or binge) during pregnancy may generate a fetal alcohol spectrum disorder phenotype and the consequences may be partially attenuated by a prenatal treatment with epigallocatechin-3-gallate.     

Multilayer lead‐free piezoceramic composites: Influence of co‐firing on microstructure and electromechanical behavior

In this study lead‐free 2‐2 and 0‐3 ceramic/ceramic composites comprised of the non‐ergodic relaxor 0.93(Bi_1/2Na_1/2)TiO₃–0.07BaTiO₃ and ergodic relaxor 0.94Bi_0.5(Na_0.75K_0.25)_0.5TiO₃–0.06BiAlO₃ were investigated. The macroscopic electromechanical behavior was characterized as a function of continuent content, revealing an enhancement in the unipolar strain from the multilayer composite structure. Systematic evaluation of the effects of co‐sintering on microstructural properties, such as grain size and porosity, revealed potential mechanisms by which the increase in unipolar strain was achieved. In addition, interdiffusion between the constituents was observed, providing evidence for the formation of a functionally graded ceramic by co‐sintering. These data are contrasted with high‐resolution energy dispersive X‐ray microanalysis for measurement of chemical composition across the interface of 2‐2 ceramics. These findings provide insight into how synthesis routes can be optimized for tailoring the enhancement of electromechanical properties of lead‐free electroceramic composite systems.     

Spline Based Pseudo‐Inversion of Sampled Data Non‐Minimum Phase Systems for an Almost Exact Output Tracking

This paper considers the problem of achieving a very accurate tracking of a pre‐specified desired output trajectory , for linear, multiple input multiple output, non‐minimum phase and/or non hyperbolic, sampled data, and closed loop control systems. The proposed approach is situated in the general framework of model stable inversion and introduces significant novelties with the purpose of reducing some theoretical and numerical limitations inherent in the methods usually proposed. In particular, the new method does not require either a preactuation or null initial conditions of the system. The desired and the corresponding sought input are partitioned in a transient component ( and u_t(k), respectively) and steady‐state ( and u_s(k), respectively). The desired transient component is freely assigned without requiring it to be null over an initial time interval. This drastically reduces the total settling time. The structure of u_t(k) is a priori assumed to be given by a sampled smoothing spline function. The spline coefficients are determined as the least‐squares solution of the over‐determined system of linear equations obtained imposing that the sampled spline function assumed as reference input yield the desired output over a properly defined transient interval. The steady‐state input u_s(k) is directly analytically computed exploiting the steady‐state output response expressions for inputs belonging to the same set of .     

Candida tropicalis biofilm formation and expression levels of the CTRG ALS-like genes in sessile cells

Candida tropicalis is an emergent pathogen with a high rate of mortality associated with it; however, less is known about its pathogenic capacity. Biofilm formation (BF) has important clinical repercussions, and it begins with adherence to a substrate. The adherence capacity depends principally on the cell surface hydrophobicity (CSH) and, at a later stage, on specific adherence due to adhesins. The ALS family in C. tropicalis, implicated in adhesion and BF, is represented in several CTRG genes. In this study, we determined the biofilm-forming ability, the primary adherence, and the CSH of C. tropicalis, including six isolates from blood and seven from urine cultures. We also compared the expression of four CTRG ALS-like genes (CTRG_01028, CTRG_02293, CTRG_03786, and CTRG_03797) in sessile versus planktonic cells, selected for their possible contribution to BF. All the C. tropicalis strains were biofilm producers, related to its filamentation capacity; all the strains displayed a high adherence ability correlated to the CSH, and all the strains expressed the CTRG genes in both types of growth. Urine isolates present, although not significantly, higher CSH, adherence, and biofilm formation than blood isolates. This study reveals that three CTRG ALS-like genes—except CTRG_03797—were more upregulated in biofilm cells, although with a considerable variation in expression across the strains studied and between the CTRG genes. C. tropicalis present a high biofilm capacity, and the overexpression of several CTRG ALS-like genes in the sessile cells suggests a role by the course of the biofilm formation.     

Changes in phenolic compounds and Rancimat stability of olive oils from varieties of olives at different stages of ripeness

BACKGROUND: Recently, diets rich in natural foods and food‐derived components, such as phenolic compounds, have received a great deal of attention because they are perceived as ‘safe’ and ‘non‐medicinal’. In fact, some are known to function as chemopreventive agents against oxidative damage, cerebrovascular disease, and aging. RESULTS: Phenolic compounds, natural antioxidants present in virgin olive oil, play an important role in oil quality by contributing significantly to protecting oil stability against oxidation. In addition, polyphenols are the main contributors to olive oil bitterness, astringency and pungency. The data were fit by linear regression, giving Rancimat stability (h) = 0.18× Total polyphenols (mg L^?1) in the virgin olive oil. CONCLUSIONS: The practice of harvesting ripe olives as soon as possible to produce oils of high phenolic contents and thus high oxidative stability implies bitter and piquant oils, this being admissible for oils of some varieties but detrimental to others appreciated in the market for being more fruity and sweeter. Copyright © 2010 Society of Chemical Industry     

Biohydrogen production from thermochemically pretreated corncob using a mixed culture bioaugmented with Clostridium acetobutylicum

Bovine ruminal fluid (BRF) bioaugmented with Clostridium acetobutylicum (Clac) was assessed for hydrolyzing cellulose and produce biohydrogen (BioH₂) simultaneously from pretreated corncob in a single step, without the use of external hydrolytic biocatalysts. The corncob was pretreated using three thermochemical methods: H₂SO₄ 2%, 160 °C; NaOH 2%, 140 °C; NaOCl 2%, 140 °C; autohydrolysis: H₂O, 190 °C. Subsequently, BioH₂ production was carried out using the pretreated material with the highest digestibility applying a Taguchi experimental array to identify the optimal operating conditions. The results showed a higher glucose released from pretreated corncob with H₂SO₄ (134.7 g/L) compared to pretreated materials by autohydrolysis, NaOH and NaOCl (123 g/L, 89.8 g/L and 52.9 g/L, respectively). The mixed culture was able to hydrolyze the pretreated corncob and produce 575 mL of H₂ (at 35 °C, pH 5.5, 1:2 ratio of BRF:Clac and 5% of solids loading) equivalent to 132 L H₂/Kg of biomass.