Extending standard evolutionary programming with self-adaptive stable distributions

Applications in evolutionary programming have suggested the use of further stable probability distributions, such as Cauchy and Lévy, in the random process associated with the mutations, as an alternative to the traditional, also stable, normal distribution. This work goes further along the encouraging results of the latter, by extending them in a self-adaptive way, with algorithms that are in tune with the standard lineage of evolutionary programming. Evaluations that rely upon standard analytical benchmarking functions and comparative performance tests between them were carried out in respect to the baseline defined by the standard evolutionary programming algorithm that relies on normal distribution. Additional comparative studies were made in respect to various self-adaptive approaches, also proposed herein, and a method drawn from the literature. The results lead to numerical and statistical superiority of the more general stable distribution based approach, when compared with the baseline, and is unclear in regard to the method drawn from the literature, possibly due to distinct implementation details.     

Scaling down of microequipment parameters

A method of micromechanical device fabrication is examined in this article. The method consists of the development of equipment which has sizes comparable with the sizes of the produced parts. There are different approaches to this problem. We propose a method of micromachine tool and micromanipulator creation. We do not use the expensive elements. To obtain the necessary precision we utilize the natural advantages of equipment of small size. In this article the error analysis of the microequipment is given and the methods of error minimization are described. An example of the developed microequipment prototypes is given.     

Tumor Accumulation and Off-Target Biodistribution of an Indocyanine-Green Fluorescent Nanotracer: An Ex Vivo Study on an Orthotopic Murine Model of Breast Cancer

Indocyanine green (ICG) is a near infrared fluorescent tracer used in image-guided surgery to assist surgeons during resection. Despite appearing as a very promising tool for surgical oncology, its employment in this area is limited to lymph node mapping or to laparoscopic surgery, as it lacks tumor targeting specificity. Recently, a nanoformulation of this dye has been proposed with the aim toward tumor targeting specificity in order to expand its employment in surgical oncology. This nanosystem is constituted by 24 monomers of H-Ferritin (HFn), which self-assemble into a spherical cage structure enclosing the indocyanine green fluorescent tracer. These HFn nanocages were demonstrated to display tumor homing due to the specific interaction between the HFn nanocage and transferrin receptor 1, which is overexpressed in most tumor tissues. Here, we provide an ex vivo detailed comparison between the biodistribution of this nanotracer and free ICG, combining the results obtained with the Karl Storz endoscope that is currently used in clinical practice and the quantification of the ICG signal derived from the fluorescence imaging system IVIS Lumina II. These insights demonstrate the suitability of this novel HFn-based nanosystem in fluorescence-guided oncological surgery.     

Estado actual de la aplicacion de computadoras a textos en español

Leopoldo Sáez-Godoy es responsable de la sección de espa?ol de la ALLC y miembro del Comité Bibliográfico de CHum.     

Multicriteria‐Based Computer‐Aided Pronunciation Quality Evaluation of Sentences

The problem of the sentence‐based pronunciation evaluation task is defined in the context of subjective criteria. Three subjective criteria (that is, the minimum subjective word score, the mean subjective word score, and first impression) are proposed and modeled with the combination of word‐based assessment. Then, the subjective criteria are approximated with objective sentence pronunciation scores obtained with the combination of word‐based metrics. No a priori studies of common mistakes are required, and class‐based language models are used to incorporate incorrect and correct pronunciations. Incorrect pronunciations are automatically incorporated by making use of a competitive lexicon and the phonetic rules of students' mother and target languages. This procedure is applicable to any second language learning context, and subjective‐objective sentence score correlations greater than or equal to 0.5 can be achieved when the proposed sentence‐based pronunciation criteria are approximated with combinations of word‐based scores. Finally, the subjective‐objective sentence score correlations reported here are very comparable with those published elsewhere resulting from methods that require a priori studies of pronunciation errors.     

Hybrid 3D Printing of Synthetic and Cell‐Laden Bioinks for Shape Retaining Soft Tissue Grafts

Despite recent advances in clinical procedures, the repair of soft tissue remains a reconstructive challenge. Current technologies such as synthetic implants and dermal flap autografting result in inefficient shape retention and unpredictable aesthetic outcomes. 3D printing, however, can be leveraged to produce superior soft tissue grafts that allow enhanced host integration and volume retention. Here, a novel dual bioink 3D printing strategy is presented that utilizes synthetic and natural materials to create stable, biomimetic soft tissue constructs. A double network ink composed of covalently cross‐linked poly(ethylene) glycol and ionically cross‐linked alginate acts as a physical support network that promotes cell growth and enables long‐term graft shape retention. This is coupled with a cell‐laden, biodegradable gelatin methacrylate bioink in a hybrid printing technique, and the composite scaffolds are evaluated in their mechanical properties, shape retention, and cytotoxicity. Additionally, a new shape analysis technique utilizing CloudCompare software is developed that expands the available toolbox for assessing scaffold aesthetic properties. With this dynamic 3D bioprinting strategy, complex geometries with robust internal structures can be easily modulated by varying the print ratio of nondegradable to sacrificial strands. The versatility of this hybrid printing fabrication platform can inspire the design of future multimaterial regenerative implants.     

A two-level finite element method and its application to the Helmholtz equation

A two-level finite element method is introduced and its application to the Helmholtz equation is considered. The method retains the desirable features of the Galerkin method enriched with residual-free bubbles, while it is not limited to discretizations using elements with simple geometry. The method can be applied to other equations and to irregular-shaped domains. © 1998 John Wiley & Sons, Ltd.     

Queen Volatiles as a Modulator of <Emphasis Type="BoldItalic">Tetragonisca angustula</Emphasis> Drone Behavior

Tetragonisca angustula mating occurs during the virgin queen nuptial flight, usually in the presence of a drone congregation area (DCA). The presence of virgin queen pheromone is considered the trigger for DCA establishment, although this has not been demonstrated experimentally. We established meliponaries, in different habitats, with T. angustula virgin queens during the main drone reproduction period. Eight DCAs were observed in urban areas, and all established outside or near colonies containing at least one virgin queen. The accumulation of drones in the DCAs occurred from 08:00 to 18:00 h and over 3–35 days. The number of drones in DCAs ranged from 60 to 2,000. In field trials, drones were attracted to virgin queens and also, unexpectedly, to physogastric queens. Volatiles collected from both virgin and physogastric queens elicited strong electoantennogram (EAG) responses from drones. Virgin and physogastric queen volatiles were qualitatively similar, but quantitatively different, in chemical composition. The queen’s abdomen was the principal source of these compounds. Isopropyl hexanoate (IPH), the most abundant compound in virgin queen volatiles and one of the most abundant in physogastric queen volatiles, was identified as one of the compounds that elicited EAG responses and was demonstrated to attract drones in a field test.     

Flexible fluorescent films based on quantum dots (QDs) and natural rubber

This article presents the fabrication and characterization of polyisoprene fluorescent films doped with CdTe quantum dots (QDs). The biopolymer (polyisoprene) is extracted from natural rubber latex, generating flexible and transparent films in visible range (transmittance over 90%) ideal as a matrix to support QDs. The water solubility of the biopolymer facilitates its doping with water dispersed QDs at room temperature to obtain the fluorescent films. Thermogravimetric analysis reveals that QDs have no significant effect on the thermal properties of the biopolymer. Photophysical characterization of the solution and solid state (films) of the QDs evidenced that the polymer matrix does not influence its emission properties, the maximum fluorescence peaks have only 2 nm of difference between the solution and solid state (films) samples. Therefore, polyisoprene from natural rubber can be considered as an excellent flexible matrix to fabricate fluorescent films with QDs. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134, 45459.     

In situ syntheses of a suspension agent based on a styrene–acrylic acid copolymer for the suspension polymerization of styrene

We carried out the suspension polymerization of styrene, initiated with benzoyl peroxide at 80°C, in the presence of the simultaneous polymerization of acrylic acid in the water phase, initiated by potassium peroxidisulfate (KPS) at the same temperature. The polymerization in the water phase was started at certain times after the beginning of the polymerization of styrene. Then, a continuous addition of KPS was carried out at a given landing rate and during variable feeding times. The water‐phase polymerization actually produced a copolymer of styrene and acrylic acid, which displayed surface‐active properties. The particle size distribution depended on the variables mentioned earlier (starting time, KPS feeding rate, and addition time), being controlled by the molecular weight, and on the composition of the copolymer produced and its availability at the increasing conversion of styrene. A second distribution of submicronic particles was produced. Both families of particles had about the same molecular weight. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 3271–3285, 2002