Enzymes of the small intestine of the calf: effect of dietary protein source on the activities of some enzymes in the small intestinal mucosa and digesta

The objective of this study was to examine the effect of dietary protein source on the morphology and enzyme activities in the small intestinal mucosa and digesta of preruminant calves. The control diet contained skim milk powder. Plant proteins from soy concentrate (unhydrolysed or partially hydrolysed) and potato concentrate were incorporated into experimental diets. Duodenal, jejunal and ileal mucosal biopsies and digesta were collected from calves fitted with simple cannulae and continuously infused with milk replacers into the abomasum. Biopsies were used for morphology measurements. The activity of dipeptidylpeptidase IV, aminopeptidases, lactase and alkaline phosphatase was estimated in biopsies and digesta. Incorporating plant protein had a limited effect on the intestinal mucosa. A partial villus atrophy and crypt hyperplasia were noted with the soy concentrate only. Decreases in the activity of dipeptidylpeptidase IV with the potato concentrate diet and of aminopeptidase N and lactase with the hydrolysed soy concentrate diet, were also observed in ileal biopsies. Mucosal enzymes were released in the lumen and most of them accumulated in digesta of the distal small intestine. The activity of aminopeptidase N and lactase in ileal digesta was higher in calves fed the soy and potato concentrate diets than in those fed the control diet. © 2002 Society of Chemical Industry     

Sediment bed destabilization by an isolated vortex:an experimental approach

The destabilization of an erodible sediment bed by a reproducible impulsive phenomenon is studied experimentally.For this,a specific setup is designed to produc...     

移动轨迹数据的可视化

GPS,RFID和无线通信设备的爆炸状发展,让人们有可能搜集到大量的车辆、人群等的移动轨迹数据(简称轨迹数据),这些数据在交通管理、流动性分析、路线推荐等很多领域有着重要的应用.轨迹数据同时包含空间和时间属性,数据量大且维度高,分析起来难度很大.可视化技术可以直观地呈现多维时空轨迹数据,并提供丰富的互动,以揭示数据中包含的时空规律.文中总结了轨迹数据的可视化技术的研究现状,介绍了多个应用案例.     

Commissioning of the Iseult CEA 11.7 T whole-body MRI: current status,gradient–magnet interaction tests and first imaging experience

Objectives

The Iseult MRI is an actively shielded whole-body magnet providing a homogeneous and stable magnetic field of 11.7 T. After nearly 20 years of research and development, the magnet successfully reached its target field strength for the first time in 2019. This article reviews its commissioning status, the gradient–magnet interaction test results and first imaging experience.

Materials and methods

Vibration, acoustics, power deposition in the He bath, and field monitoring measurements were carried out. Magnet safety system was tested against outer magnetic perturbations, and calibrated to define a safe operation of the gradient coil. First measurements using parallel transmission were also performed on an ex-vivo brain to mitigate the RF field inhomogeneity effect.

Results

Acoustics measurements show promising results with sound pressure levels slightly above the enforced limits only at certain frequency intervals. Vibrations of the gradient coil revealed a linear trend with the B₀ field only in the worst case. Field monitoring revealed some resonances at some frequencies that are still under investigation.

Discussion

Gradient-magnet interaction tests at up to 11.7 T are concluded. The scanner is now kept permanently at field and the final calibrations are on-going to pave the road towards the first acquisitions on volunteers.

     

On electron loss lowering at hematite photoelectrode interfaces

Photoelectrodes nanoscale interface design has become a key factor to enhancing their photoelectrochemical performance for water splitting by reducing the photogenerated charge recombination, thus ensuring their efficient separation, transport, and collection. In this work, hematite (α-Fe₂O₃) photoanodes were prepared from a simple and scalable methodology capable of synergistically mitigating the charge loss and recombination at all interfaces (i.e., fluorine-doped tin oxide/hematite, hematite/hematite, and hematite/electrolyte) and achieving overall efficiency of ∼50% for the water oxidation reaction compared to pristine photoelectrodes. The external quantum efficiency at 1.23 V versus reversible hydrogen electrode of pristine hematite was enhanced 6.7 times with the modifications of the three interfaces (Al₂O₃/NbH/NiFeO_x). Electrochemical impedance spectroscopy and intensity-modulated photocurrent spectroscopies were applied to probe and monitor the photogenerated charge carrier dynamics revealing a substantial improvement in charge separation and collection at the back-contact interface as well as a partial mitigation of the surface states at the hematite–electrolyte interface.     

From P-type to N-type: Peripheral fluorination of axially substituted silicon phthalocyanines enables fine tuning of charge transport

Silicon phthalocyanines (R₂-SiPcs) are a family of promising tunable materials for organic electronic applications. We report the chemistry of the synthesis of axially substituted fluorinated SiPcs (tb-Ph)₂-F_xSiPc (where X = 0, 4, 8, or 16) and explore how the degree of fluorination effects optical and electronic properties. A new treatment with boron trichloride was included to obtain Cl₂-F_XSiPcs from F₂-F_XSiPcs, activating the axial position for further functionalization. We observed that as the degree of fluorination increased, so did the electron affinity of the compounds, leading to a drop in frontier orbital levels, as measured by electrochemistry and ultraviolet photoelectron spectroscopy (UPS). The deeper energy levels enabled successful (tb-Ph)₂-F₄SiPc and poly [[6,7-difluoro[(2-hexyldecyl)oxy]-[5,8-quinoxalinediyl]-2,5-thiophenediyl]] (PTQ10) blends for organic photovoltaics and photodetectors. All four compounds were incorporated in organic thin-film transistors (OTFTs), where the degree of fluorination influenced device operation, changing it from p-type conduction for (tb-Ph)₂-F₀SiPc, to ambipolar for (tb-Ph)₂-F₄SiPc, and n-type for (tb-Ph)₂-F₈SiPc and (tb-Ph)₂-F₁₆SiPc. The OTFT devices made with (tb-Ph)₂-F₁₆SiPc achieved a low average threshold voltage of 7.0 V in N₂ and retained its n-type mobility when exposed to air.     

A Comprehensive Review on Barium Titanate Nanoparticles as a Persuasive Piezoelectric Material for Biomedical Applications: Prospects and Challenges

Stimulation of cells with electrical cues is an imperative approach to interact with biological systems and has been exploited in clinical practices over a wide range of pathological ailments. This bioelectric interface has been extensively explored with the help of piezoelectric materials, leading to remarkable advancement in the past two decades. Among other members of this fraternity, colloidal perovskite barium titanate (BaTiO₃) has gained substantial interest due to its noteworthy properties which includes high dielectric constant and excellent ferroelectric properties along with acceptable biocompatibility. Significant progression is witnessed for BaTiO₃ nanoparticles (BaTiO₃ NPs) as potent candidates for biomedical applications and in wearable bioelectronics, making them a promising personal healthcare platform. The current review highlights the nanostructured piezoelectric bio interface of BaTiO₃ NPs in applications comprising drug delivery, tissue engineering, bioimaging, bioelectronics, and wearable devices. Particular attention has been dedicated toward the fabrication routes of BaTiO₃ NPs along with different approaches for its surface modifications. This review offers a comprehensive discussion on the utility of BaTiO₃ NPs as active devices rather than passive structural unit behaving as carriers for biomolecules. The employment of BaTiO₃ NPs presents new scenarios and opportunity in the vast field of nanomedicines for biomedical applications.     

Microwave inactivation of Escherichia coli K12 CIP 54.117 in a gel medium: Experimental and numerical study

This study evaluates the efficiency of the inactivation of Escherichia coli K12, entrapped within calcium alginate gel, by microwave processing compared to a conventional approach i.e. by heating in a water bath. Microbial thermal inactivation equations coupled with heat transfer and Maxwell’s equations are integrated into a 3D Finite Elements model under dynamic heating conditions. Water bath microbial inactivation experimental data are exploited for performing parameter identification of a non-linear microbial model, and the Calcium alginate gel’s dielectric properties were numerically estimated. The coupled model provides a very good fitting to the experimental results. The simulation have shown uneven temperature distribution during microwave heating which may interpret its lower inactivation efficiency comparing to the conventional water bath treatment. This study also demonstrates the reliability of the coupled modeling approach to estimate the efficiency of the microbial inactivation, despite the thermal heterogeneity inherent in the microwave treatment.