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排序方式: 共有1545条查询结果,搜索用时 15 毫秒
81.
It is shown that peroxidation of phosphatidylcholine (PC) is enhanced in liver of mice fed a hepatocarcinogenic choline-deficient
diet containing 0.1% w/w ethionine. Mice were divided into 4 groups and fed for 3 weeks one of the following diets: choline-supplemented;
choline-supplemented containing ethionine; choline-deficient; and choline-deficient containing ethionine. Phosphatidylcholine
hydroperoxide (PCOOH) of liver lipids was measured by high performance liquid chromatography using a chemiluminescence detector.
Mice fed a choline-deficient diet containing ethionine showed 6-fold higher PCOOH levels than the choline-supplemented control
mice: the PCOOH/PC molar ratios of liver lipids were 32.3×10−5 and 5.6×10−5, respectively. In addition to this remarkable degree of lipid peroxidation in liver of mice fed the choline-deficient diet
containing ethionine, we also observed a significant liver fatty infiltration, a decrease in plasma and liver α-tocopherol,
and an increase in liver injury-indicative enzyme activities. Also, marker enzymes for hepatocarcinogenesis, glucose-6-phosphatase
and γ-glutamyl transpeptidase were affected. These data suggest that enhanced hydroperoxidation of phosphatidylcholine may
participate in hepatocarcinogenesis provoked by choline deficiency in the presence of ethionine. 相似文献
82.
Maria Lisa Garavaglia Daniela Giustarini Graziano Colombo Francesco Reggiani Silvia Finazzi Marta Calatroni Lucia Landoni Nicola Marcello Portinaro Aldo Milzani Salvatore Badalamenti Ranieri Rossi Isabella Dalle-Donne 《International journal of molecular sciences》2022,23(5)
Thiols (sulfhydryl groups) are effective antioxidants that can preserve the correct structure of proteins, and can protect cells and tissues from damage induced by oxidative stress. Abnormal levels of thiols have been measured in the blood of patients with moderate-to-severe chronic kidney disease (CKD) compared to healthy subjects, as well as in end-stage renal disease (ESRD) patients on haemodialysis or peritoneal dialysis. The levels of protein thiols (a measure of the endogenous antioxidant capacity inversely related to protein oxidation) and S-thiolated proteins (mixed disulphides of protein thiols and low molecular mass thiols), and the protein thiolation index (the molar ratio of the S-thiolated proteins to free protein thiols in plasma) have been investigated in the plasma or red blood cells of CKD and ESRD patients as possible biomarkers of oxidative stress. This type of minimally invasive analysis provides valuable information on the redox status of the less-easily accessible tissues and organs, and of the whole organism. This review provides an overview of reversible modifications in protein thiols in the setting of CKD and renal replacement therapy. The evidence suggests that protein thiols, S-thiolated proteins, and the protein thiolation index are promising biomarkers of reversible oxidative stress that could be included in the routine monitoring of CKD and ESRD patients. 相似文献
83.
Angelo G. Giumanini Giancarlo Verardo Ennio Zangrando Lucia Lassiani 《Advanced Synthesis \u0026amp; Catalysis》1987,329(6):1087-1103
A product study of the reaction between a number of aromatic amines substituted with widely different groups and paraformaldehyde in inert solvents was performed and found to yield 1,3,5-triaryl-1,3,5-hexahydrotriazines, 1,3,5,7-tetraaryl-1,3,5,7-tetrazocines and formaminals. It was not possible to correlate the product outcomes with the actual structure of the amine substrate. The X-ray diffraction structural determination of 1,3,5-tri-(t-butylphenyl)-( 1b ) and 1,3,5-tri-(m-fluorophenyl)-1,3,5-hexahydrotriazine ( 1c ) showed the diaxial arrangement of the N-substituents. 相似文献
84.
Francesco Borgia Lucia Peterle Paolo Custurone Mario Vaccaro Giovanni Pioggia Sebastiano Gangemi 《International journal of molecular sciences》2022,23(6)
Acne Vulgaris (AV) and Hidradenitis suppurativa (HS) are common chronic inflammatory skin conditions that affect the follicular units that often coexist or are involved in differential diagnoses. Inflammation in both these diseases may result from shared pathways, which may partially explain their frequent coexistence. MicroRNAs (miRNAs) are a class of endogenous, short, non-protein coding, gene-silencing or promoting RNAs that may promote various inflammatory diseases. This narrative review investigates the current knowledge regarding miRNAs and their link to AV and HS. The aim is to examine the role of these molecules in the pathogenesis of AV and HS and to identify possible common miRNAs that could explain the similar characteristics of these two diseases. Five miRNA (miR-155 miR-223-, miR-21, and miRNA-146a) levels were found to be altered in both HS and AV. These miRNAs are related to pathogenetic aspects common to both pathologies, such as the regulation of the innate immune response, regulation of the Th1/Th17 axis, and fibrosis processes that induce scar formation. This review provides a starting point for further studies aimed at investigating the role of miRNAs in AV and HS for their possible use as diagnostic-therapeutic targets. 相似文献
85.
Advances in Bioapplications of Carbon Nanotubes 总被引:1,自引:0,他引:1
Fushen Lu Lingrong Gu Mohammed J. Meziani Xin Wang Pengju G. Luo Lucia Monica Veca Li Cao Ya‐Ping Sun 《Advanced materials (Deerfield Beach, Fla.)》2009,21(2):139-152
This progress report provides an overview on recent advances in bioapplications of carbon nanotubes including the chemical modification of carbon nanotubes, targeting specifically their covalent and noncovalent conjugations with a variety of biological and bioactive species (proteins and peptides, DNAs/RNAs, and carbohydrates). Furthermore, the significant recent development and progress in the use of carbon nanotubes for biosensors, drug and other delivery systems, bioimaging, etc. and in the understanding of in vivo biodistribution and toxicity of carbon nanotubes are reported. 相似文献
86.
Simon Barquera Fabricio Campirano Anabelle Bonvecchio Lucia Hernández-Barrera Juan A Rivera Barry M Popkin 《Nutrition journal》2010,9(1):47
Background
Mexico has seen a very steep increase in child obesity level. Little is known about caloric beverage intake in this country as well as all other countries outside a few high income countries. This study examines overall patterns and trends in all caloric beverages from two nationally representative surveys from Mexico. 相似文献87.
Jack A. Neal Betsy Booren Luis Cisneros-Zevallos Rhonda K. Miller Lisa M. Lucia Joseph E. Maxim Alejandro Castillo 《Journal of food science》2010,75(6):S319-S326
Abstract: The use of ionizing radiation for the control of foodborne pathogens and extending the shelf life of fresh iceberg lettuce and fresh spinach has recently been approved by the U.S. Food and Drug Administration. The efficacy of electron beam irradiation for controlling foodborne pathogens has been reported. For this experiment, the effectiveness of electron beam irradiation on the microbiological and sensory characteristics of fresh spinach was studied. Total aerobic plate counts were reduced by 2.6 and 3.2 log CFU/g at 0.7 and 1.4 kGy, respectively. Lactic acid bacteria were reduced at both doses of e-beam but grew slowly over the 35 d of the experiment. Yeasts and molds were not reduced in samples exposed to 0.7 kGy whereas 1.4 kGy significantly reduced microbial counts. Gas compositions (O2 and CO2) were significantly different than controls. Oxygen levels inside the spinach sample bags decreased over time; however, O2 levels did not drop below 1% that can induce anaerobic fermentation. CO2 levels for all treatments increased through day 4; yet 7 d after irradiation, CO2 level differences were not significant in both control and irradiated samples. Irradiation dose did not affect the basic tastes, aromatics, or mouth feels of fresh spinach, however; hardness attributes decreased as irradiated dose increased and slimy attributes of fresh spinach were higher in control samples compared to irradiated samples. 相似文献
88.
Lucia D’Urzo Benedetto Bozzini 《Journal of Materials Science: Materials in Electronics》2009,20(7):666-670
In this paper we investigate the corrosive behaviour of various volatile organic compounds (VOCs) on electroplated copper.
The VOCs we considered were of the following types: (i) aromatic and substituted-aromatic compounds (benzene, toluene and
ethyl benzene); (ii) a chlorine-substituted hydrocarbon (dichloromethane) and (iii) an aliphatic alcohol (isopropyl alcohol).
Contamination by VOCs is typical of ULSI (Ultra Large Scale Integration) manufacturing environments, and exposure of Cu to
VOC-contaminated clean room air has been pinpointed as a serious cause of interconnects failure. SEM observation highlighted
corrosion signature that are typical of the different classes of molecules. In particular, the corrosion of copper is almost
absent following exposure to isopropyl alcohol, very slow in the case of aromatic molecules and severe in the case of dichloromethane.
The obtained results can be interpreted in terms of a crevice corrosion mechanism under droplets, enhanced by pitting in the
presence of chlorinated solvents. 相似文献
89.
90.