An unusual case of large right atrial myxoma

A case of right atrial myxoma is described. The patient had vague and variable symptoms and it was not until five years after first presentation that she had developed clinical and electrocardiographic evidence of right atrial hypertrophy, and angiocardiographic evidence of a fist-sized myxoma which was subsequently removed surgically.     

Undifferentiated X-linked oligophrenias

In the course of investigation of 262 families with non-differentiated forms of oligophrenias it is established that in 48 families (18.3%) mental deficiency in sibs is caused by pathological mutations in the X-chromosome. Besides, it is not excluded that in certain inbred families oligophrenia in female persons is also, due to mutations linked with X-chromosome. This is supported by the dependence established between the frequency of the cases of oligophrenia among female persons and the inbreeding coefficient for the X-linked loci. The possibility of manifestation of the recessive genes of oligophrenia linked with X-chromosomes in heterozygous state is discussed.     

The biologic actions of solar radiation on skin with a note on sunscreens

Adverse effects of excessive cutaneous exposure to solar radiation are hazards of considerable importance. As public health measures, new attitudes about sunbathing and new practices to counteract those adverse effects, especially for high-risk individuals, appear warranted.     

Incorporation of 15N from ammonium into the N-linked oligosaccharides of an immunoadhesin glycoprotein expressed in Chinese hamster ovary cells

Thirty-six isolates, from man or swine, of Pasteurella multocida subsp. multocida producing (n = 13) or not producing (n = 23) the dermonecrotic toxin (DNT) were studied by numerical analysis, capsular typing and ribotyping. Toxigenic strains were also characterised by restriction fragment length polymorphism (RFLP) of the toxA gene and pulsed-field gel electrophoresis (PFGE). Numerical analysis differentiated the Pasteurella species and subspecies, but did not discriminate between toxigenic and nontoxigenic strains. RFLP demonstrated that toxA was located in a conserved part of the chromosome of all toxigenic strains. Ribotyping provided evidence of a close association between DNT production and one of the six EcoRI ribotypes designated as E2. In contrast, PFGE provided evidence for significant DNA polymorphism amongst the toxigenic strains. Results of phenotypic and genotypic studies suggested that toxigenic strains do not form a clone within the subspecies multocida. No difference was found between toxigenic strains of porcine or human origin by biochemical characterisation, capsular serotyping or genomic typing methods.