设备闸门提升与导向装置运行特性仿真分析

对核电厂设备闸门提升与导向装置在设备闸门封头开启与关闭过程中的运动特性进行了分析研究,该研究借助动力学仿真软件ADAMS展开,分别对提升与导向装置可能出现的同步提升操作和不同步提升操作两种工况进行了仿真分析。分析结果表明:在同步提升操作工况下,设备闸门封头两侧导向箱位移一致,提升与导向装置不会产生卡滞;在不同步提升操作工况下,设备闸门封头两侧导向箱最大允许高度差为54 mm,否则提升与导向装置将产生卡滞。     

控制棒落棒动力学数值计算

控制棒在安全停堆时的下落时间和下落规律是核电厂安全分析的重要参数。本文针对一种超临界水冷堆控制棒组件,采用计算流体动力学(CFD)瞬态动网格数值分析方法研究某控制棒的下落过程,分析其流场演化规律,并得到了控制棒下落过程中位移随时间、速度随时间及加速度随时间的变化规律。同时,研究了控制棒、通道发生变形时对控制棒下落规律的影响。本文的计算方法及结果对控制棒结构优化具有指导意义。     

Synthesis and dissociation of soliton molecules in parallel optical-soliton reactors

Mode-locked lasers have been widely used to explore interactions between optical solitons, including bound-soliton states that may be regarded as"photonic molec...     

调质型耐磨钢WNM400的研制开发

本文通过参考相关文献资料及国内外同等级别耐磨钢标准,设计了舞钢调质型耐磨钢WNM400A的化学成分,确定了冶炼及轧制工艺,研究了淬火、回火工艺对WNM400A钢性能的影响.     

新型一袋化堵漏技术在塔河油田中的应用

针对塔河油田奥陶系缝洞型储层易井漏、堵漏浆难以滞留、堵漏配方和工艺复杂的难题,提出了理想填充-紧密堆积理论结合的思路。通过优选可酸溶堵漏材料及其颗粒级配,研究形成封堵1～5 mm不同尺寸裂缝的5套堵漏配方,室内承压能力在10 MPa以上,酸溶率超过75%。上述堵漏配方分别生产为一袋化产品,在塔河油田X13H井和X193井奥陶系储层堵漏均一次成功。新型一袋化堵漏技术的配方颗粒级配和施工工艺合理有效,且实现了可酸溶解堵。     

塔河油田抽油杆断脱统计分析及优化对策

近年来抽油杆断脱成为塔河油田抽油机井检泵作业的主要因素,严重影响了油井正常生产,造成大量经济及产量损失。通过统计分析认为,交变载荷大造成的疲劳断以及泵挂深导致的抽油杆偏磨断是造成抽油杆断脱的主要原因。针对断脱的主要因素,在2015年开始从优化设计、加强管理、引入新技术等3个方面进行了综合治理,降低了杆断检泵频次,年节约修井费用181万元,年减少产量损失439 t,取得了较好的效益。     

Expression Patterns and Gonadotropin Regulation of the TGF-β II Receptor (Bmpr2) during Ovarian Development in the Ricefield Eel Monopterus albus

Bmpr2 plays a central role in the regulation of reproductive development in mammals, but its role during ovarian development in fish is still unclear. To ascertain the function of bmpr2 in ovarian development in the ricefield eel, we isolated and characterized the bmpr2 cDNA sequence; the localization of Bmpr2 protein was determined by immunohistochemical staining; and the expression patterns of bmpr2 in ovarian tissue incubated with FSH and hCG in vitro were analyzed. The full-length bmpr2 cDNA was 3311 bp, with 1061 amino acids encoded. Compared to other tissues, bmpr2 was abundantly expressed in the ovary and highly expressed in the early yolk accumulation (EV) stages of the ovary. In addition, a positive signal for Bmpr2 was detected in the cytoplasm of oocytes in primary growth (PG) and EV stages. In vitro, the expression level of gdf9, the ligand of bmpr2, in the 10 ng/mL FSH treatment group was significantly higher after incubation for 4 h than after incubation for different durations. However, bmpr2 expression in the 10 ng/mL FSH treatment group at 2 h, 4 h and 10 h was significantly lower. Importantly, the expression level of bmpr2 and gdf9 in the 100 IU/mL hCG group had similar changes that were significantly decreased at 4 h and 10 h. In summary, Bmpr2 might play a pivotal role in ovarian growth in the ricefield eel, and these results provide a better understanding of the function of bmpr2 in ovarian development and the basic data for further exploration of the regulatory mechanism of gdf9 in oocyte development.     

Progress in Laser Ablation and Biological Synthesis Processes: “Top-Down” and “Bottom-Up” Approaches for the Green Synthesis of Au/Ag Nanoparticles

Because of their small size and large specific surface area, nanoparticles (NPs) have special properties that are different from bulk materials. In particular, Au/Ag NPs have been intensively studied for a long time, especially for biomedical applications. Thereafter, they played a significant role in the fields of biology, medical testing, optical imaging, energy and catalysis, MRI contrast agents, tumor diagnosis and treatment, environmental protection, and so on. When synthesizing Au/Ag NPs, the laser ablation and biosynthesis methods are very promising green processes. Therefore, this review focuses on the progress in the laser ablation and biological synthesis processes for Au/Ag NP generation, especially in their fabrication fundamentals and potential applications. First, the fundamentals of the laser ablation method are critically reviewed, including the laser ablation mechanism for Au/Ag NPs and the controlling of their size and shape during fabrication using laser ablation. Second, the fundamentals of the biological method are comprehensively discussed, involving the synthesis principle and the process of controlling the size and shape and preparing Au/Ag NPs using biological methods. Third, the applications in biology, tumor diagnosis and treatment, and other fields are reviewed to demonstrate the potential value of Au/Ag NPs. Finally, a discussion surrounding three aspects (similarity, individuality, and complementarity) of the two green synthesis processes is presented, and the necessary outlook, including the current limitations and challenges, is suggested, which provides a reference for the low-cost and sustainable production of Au/Ag NPs in the future.     

Nicotinamide Mononucleotide Supplementation Improves Mitochondrial Dysfunction and Rescues Cellular Senescence by NAD+/Sirt3 Pathway in Mesenchymal Stem Cells

In vitro expansion-mediated replicative senescence has severely limited the clinical applications of mesenchymal stem cells (MSCs). Accumulating studies manifested that nicotinamide adenine dinucleotide (NAD⁺) depletion is closely related to stem cell senescence and mitochondrial metabolism disorder. Promoting NAD⁺ level is considered as an effective way to delay aging. Previously, we have confirmed that nicotinamide mononucleotide (NMN), a precursor of NAD⁺, can alleviate NAD⁺ deficiency-induced MSC senescence. However, whether NMN can attenuate MSC senescence and its underlying mechanisms are still incompletely clear. The present study herein showed that late passage (LP) MSCs displayed lower NAD⁺ content, reduced Sirt3 expression and mitochondrial dysfunction. NMN supplementation leads to significant increase in intracellular NAD⁺ level, NAD⁺/ NADH ratio, Sirt3 expression, as well as ameliorated mitochondrial function and rescued senescent MSCs. Additionally, Sirt3 over-expression relieved mitochondrial dysfunction, and retrieved senescence-associated phenotypic features in LP MSCs. Conversely, inhibition of Sirt3 activity via a selective Sirt3 inhibitor 3-TYP in early passage (EP) MSCs resulted in aggravated cellular senescence and abnormal mitochondrial function. Furthermore, NMN administration also improves 3-TYP-induced disordered mitochondrial function and cellular senescence in EP MSCs. Collectively, NMN replenishment alleviates mitochondrial dysfunction and rescues MSC senescence through mediating NAD⁺/Sirt3 pathway, possibly providing a novel mechanism for MSC senescence and a promising strategy for anti-aging pharmaceuticals.