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51.
52.
This study examined group processes in a synchronous context and their effects on performance, assuming that these processes would be strongly dependent on the salience of social identity. It was predicted that the mere categorization of students into an online group and comparison with other groups, 2 basic conditions related to social identity, would enhance group identification, interaction patterns, and group performance in a relatively complex academic task. As predicted, the categorization manipulation enhanced group identification and increased task- and morale-building communication. It was not related to performance. These findings invite a more thorough examination of the impact of social identity on the building of a sense of online community at the early stage of a learning process. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   
53.
Fungal infections, including those caused by antifungal-resistant Candida, are a very challenging health problem worldwide. Whereas different ruthenium complexes were previously studied for their anti-Candida potential, Ru-cyclopentadienyl complexes were overlooked. Here, we report an antifungal activity assessment of three Ru-cyclopentadienyl complexes with some insights into their potential mode of action. Among these complexes, only the cationic species [Ru-ACN]+ and [Ru-ATZ]+ displayed a significant antifungal activity against different Candida strains, notably against the ones that did not respond to one of the most currently used antifungal drugs fluconazole (FCZ). However, no apparent activity was observed for the neutral species, Ru−Cl, thus indicating the important role of the cationic backbone of these complexes in their biological activity. We suggest that reactive oxygen species (ROS) generation might be involved in the mechanism of action of these complexes as, unlike neutral Ru−Cl, [Ru-ACN]+ and [Ru-ATZ]+ could generate intracellular concentration-dependent ROS. We also observed a correlation between the ruthenium cellular uptake, ROS generation and fungal growth inhibitory activity of the compounds. Furthermore, docking simulations showed that the CYP51 enzyme can form more energetically favorable complexes with [Ru-ATZ]+ than fluconazole (FCZ); this suggests that CYP51 inhibition could also be considered as a potential mode of action.  相似文献   
54.
The extracellular matrix (ECM) of the small intestinal submucosa (SIS) was harvested by removing the superficial layers of the mucosa and the external muscular layers. The remaining 80 microns thick sheet was disinfected and sterilized by methods which removed all cellular components. The SIS-ECM, retaining its native 3-dimensional microarchitecture and composition, was evaluated for its ability to support in vitro cell growth. Six separate cell types were seeded either alone or in coculture with other cells upon this matrix, grown in selected media, a examined daily for time periods ranging from 48 h to 2 weeks. The six cell types tested were NIH Swiss mouse 3T3 fibroblast, NIH 3T3/j2 fibroblasts, primary human fibroblasts, primary human keratinocytes, human microvascular endothelial cells (HMECs), and an established rat osteosarcoma (ROS) cell line. All cell types showed the ability to attach a proliferate. All fibroblast cell line and the keratinocytes proliferated and/or migrated into the 3-dimensional scaffold of the SIS matrix. The ROS cells and the HMECs were confined in their growth pattern to the surface of the matrix. Coculturing of NIH 3T3/J2 fibroblasts and primary human keratinocytes resulted in a distinctive spatial orientation of the two cell types. The fibroblast populated the mid-substance of the 3-dimensional matrix and the keratinocytes formed an epidermal structure with rete ridge-like formation and stratification when the composite was lifted to an air liquid interface in culture. In summary, SIS provides a substratum with a 3-dimensional scaffold that allows for cell migration and spatial organization. The substratum is suitable for in vitro studies of the interaction between epithelial or mesenchymal cells and a naturally occurring extracellular matrix.  相似文献   
55.
Summary  Two preparations of dry fermented sausage inoculated with one of four different strains of Staphylococcus were prepared a week apart and tested twice by 10 trained assessors. Profiles of eight attributes (vinegar, dry sausage, fat, dry cured-ham, pâté, milk, butter and nutty) were monadically assessed twice and scored on non-structured scales. During the first two sessions subjects tasted twice the four dry sausages from both preparations, and during the last two sessions 7 days later they assessed the odour of the same samples in duplicate by sparging with air. Principal component analysis showed that the eight samples (four strains X two preparations) of dry sausage were described similarly by tasting and sniffing except for the fat attribute. The principal component analysis showed that the eight samples of dry sausage were better discriminated by smell than by taste. The smelling procedure resulted in a better recognition of dry sausages inoculated with the same strain of Staphylococcus than that by tasting. Variance analysis showed that product effect was significant on common odour and flavour attributes: 'vinegar', 'fat' and 'butter'; and it was never significant on 'nutty' and 'pâté'. The F-values for 'vinegar', 'fat', 'dry-ham', 'milk' and 'butter' were higher by smell than by taste. Only 'dry-sausage' was better distinguished by taste.  相似文献   
56.
Multi-Modal Locomotion Robotic Platform Using Leg-Track-Wheel Articulations   总被引:5,自引:0,他引:5  
Other than from its sensing and processing capabilities, a mobile robotic platform can be limited in its use by its ability to move in the environment. Legs, tracks and wheels are all efficient means of ground locomotion that are most suitable in different situations. Legs allow to climb over obstacles and change the height of the robot, modifying its viewpoint of the world. Tracks are efficient on uneven terrains or on soft surfaces (snow, mud, etc.), while wheels are optimal on flat surfaces. Our objective is to work on a new concept capable of combining different locomotion mechanisms to increase the locomotion capabilities of the robotic platform. The design we came up with, called AZIMUT, is symmetrical and is made of four independent leg-track-wheel articulations. It can move with its articulations up, down or straight, allowing the robot to deal with three-dimensional environments. AZIMUT is also capable of moving sideways without changing its orientation, making it omnidirectional. By putting sensors on these articulations, the robot can also actively perceive its environment by changing the orientation of its articulations. Designing a robot with such capabilities requires addressing difficult design compromises, with measurable impacts seen only after integrating all of the components together. Modularity at the structural, hardware and embedded software levels, all considered concurrently in an iterative design process, reveals to be key in the design of sophisticated mobile robotic platforms.This research is supported financially by the Canada Research Chair (CRC) program, the Natural Sciences and Engineering Research Council of Canada (NSERC), the Canadian Foundation for Innovation (CFI) and the Faculty of Engineering of the Université de Sherbrooke. Patent pending.François Michaud is the Canada Research Chairholder in Autonomous Mobile Robots and Intelligent Systems, and an Associate Professor at the Department of Electrical Engineering and Computer Engineering of the Université de Sherbrooke. He is the principal investigator of LABORIUS, a research laboratory working on applying AI methodologies in the design of intelligent autonomous systems that can assist humans in everyday lives. His research interests are architectural methodologies for intelligent decision making, autonomous mobile robotics, social robotics, robot learning and intelligent systems. He received his bachelors degree, Masters degree and Ph.D. degree in Electrical Engineering from the Université de Sherbrooke. He is a member of IEEE, AAAI and OIQ (Ordre des ingénieurs du Québec).Dominic Létourneau has a Bachelor degree in Computer Engineering and a Masters degree in Electrical Engineering from the Université de Sherbrooke. Since 2001, he is a research engineer at the LABORIUS Mobile Robotics and Intelligent Systems Laboratory. His research interests cover combination of systems and intelligent capabilities to increase the usability of autonomous mobile robots in the real world. His expertise lies in artificial vision, mobile robotics, robot programming and integrated design. He is a member of OIQ (Ordre des ingénieurs du Québec).Martin Arsenault has a Bachelor degree in Mechanical Engineering and from the Université de Sherbrooke. For AZIMUT, he developed the Direction subsystem.Yann Bergeron is a Mechanical Junior Engineer working in a consulting engineering firm, Groupe HBA. His field of activity is most oriented in industrial projects and construction. He received his bachelors degree in Mechanical Engineering from the University de Sherbrooke. For AZIMUT, he worked on the Track-Wheel subsystem. He is a member of OIQ (Ordre des ingénieurs du Québec) and JECQ (Jeunes entrepreneurs du Centre-du-Québec).Richard Cadrin has a Bachelor degree in Mechanical Engineering from the Université de Sherbrooke. For AZIMUT, he worked on the Propulstion subsystem.Frédéric Gagnon has a Bachelor degree in Mechanical Engineering and from the Université de Sherbrooke. For AZIMUT, he designed the chassis and worked on the integration of the articulations, the bodywork and the hardware. He is currently a research engineer at LABORIUS, working on AZIMUTs second prototype and other robotic projects. He also contributes in a mobile robotic.Marc-Antoine Legault has a Bachelor degree in Mechanical Engineering from the Université de Sherbrooke, and is currently pursuing a Masters degree at LABORIUS on serial-elastic actuators. He worked on AZIMUTs Propulsion subsystem. He also works on the design of other mobile robotic platforms. He is a member of OIQ (Ordre des ingénieurs du Québec).Mathieu Millette has a Bachelor degree in Mechanical Engineering from the Université de Sherbrooke. For AZIMUT, he developed the Tensor subsystem and he designed and integrated the battery support inside the chassis. He is now working as a junior mechanical engineer in process and technical development in a third sector mill.Jean-François Paré graduated in Mechanical Engineering from the Université de Sherbrooke. He is also trained as a professional coach from R.I.C.K. (Réseau International de Coaching Kokopelli). He launched is own business in individual coaching, team coaching, team building and coaching workshops. For businesses and individuals, he assists people in reaching their well-being and efficiency and to manifest their leadership.Marie-Christine Tremblay has obtained a Bachelor degree in Mechanical Engineering from the Université de Sherbrooke. As a part of the AZIMUTõs team, she contributed the Track-Wheel subsystem and developed a new track with high adherence and wear resistance to climb stairs. She is working in the Engineering Department at Hydra-Fab Industriel, a company conceiving electro-hydraulic systems for high speed trains.Pierre Lepage has a Computer Engineering degree from the Université de Sherbrooke. For AZIMUT, he designed the user interface to control the robot and the propulsion system. He is currently a research engineer at LABORIUS, working on AZIMUTs second prototype and other robotic projects. He is involved in research projects on coordinated behavior of a group of mobile robots. He is also actively involved in a mobile robotic startup.Yan Morin has an Electrical Engineering degree from the Université de Sherbrooke. For AZIMUT, he designed the electrical interface to control the motors of the robot. He is currently a research engineer at LABORIUS, working on AZIMUTs second prototype and other robotic projects. He is also actively involved in a mobile robotic startup.Jonathan Bisson has a Bachelor degree in Computer Engineering and a Masters degree in Electrical Engineering from the Université de Sherbrooke. His contribution to AZIMUT was on the modular distributed computing architecture. His expertise lies in electronics, motor control, embedded systems and ultrasonic transducers.Serge Caron is technician in computer systems at the Department of Electrical Engineering and Computer Engineering of the Universit de Sherbrooke. His interests are in designing mobile robotic platforms, from four-legged to wheeled robots. He is also a writer for hobbyist robotic journals.  相似文献   
57.
The purpose of this work was to investigate, by numerical simulation, the effect of isotropic and anisotropic strain on the transport properties of Mg2Si. Analysis of the effects of temperature and charge-carrier concentration on evolution of the energy gap and on the thermoelectric properties of strained Mg2Si is also reported in this paper. Gap evolution is highly dependent on the type of strain applied to the structure. The Seebeck coefficient (S) and power factor (PF) are strongly modified; a gain of up to 40% can be obtained for S and up to 100% for PF under specific conditions of strain. In most cases the temperature corresponding to the maximum value of PF was found to shift downward under the effect of strain.  相似文献   
58.
Reports an error in "Prédicteurs des pratiques parentales: Cognitions sociales parentales et comportement des enfants TDAH" by Marie-Christine Beaulieu and Sylvie Normandeau (Canadian Journal of Behavioural Science/Revue canadienne des sciences du comportement, Advanced Online Publication, Jul 25, 2011, np). There was an error in the English abstract. This error is corrected in the correction. (The following abstract of the original article appeared in record 2011-15455-001.) The purpose of this study was to examine the association between parental social cognitions (parental causal attributions, parental self-efficacy) and the behavioural characteristics of their child (ADHD subtypes, comorbidity, oppositional and anxiety/shy symptoms). Participants were 110 families with a child with ADHD (ADHD-I : n = 31, ADHD-H : n = 11, ADHD-C : n = 68). Multiple regressions show that parental self-efficacy is associated with more use of appropriate discipline, praise and incentives, positive verbal discipline, and less use of harsh and inconsistent discipline and physical punishment. Results also show that parental causal attributions for the child's misbehaviour to their own efforts are a predictor of positive verbal discipline whereas parents' causal attributions for the child's misbehaviour to the child's lack of efforts are a predictor of harsh and inconsistent discipline. Parents' perception of their child's oppositional symptom is a predictor of appropriate discipline and positive verbal discipline. Finally, children's comorbidity is a predictor of harsh and inconsistent discipline. The findings of this study highlight the importance of parental self-efficacy, because from all the variables studied, it shows the strongest association with positive and negative parenting practices. No association between ADHD subtype and parenting practices were observed. Implications of these results are explored in the discussion. (PsycINFO Database Record (c) 2011 APA, all rights reserved)  相似文献   
59.

Testing is a widely applied technique to evaluate software quality, and coverage criteria are often used to assess the adequacy of a generated test suite. However, manually constructing an adequate test suite is typically too expensive, and numerous techniques for automatic test-suite generation were proposed. All of them come with different strengths. To build stronger test-generation tools, different techniques should be combined. In this paper, we study cooperative combinations of verification approaches for test generation, which exchange high-level information. We present CoVeriTest, a hybrid technique for test-suite generation. CoVeriTest iteratively applies different conditional model checkers and allows users to adjust the level of cooperation and to configure individual time limits for each conditional model checker. In our experiments, we systematically study different CoVeriTest cooperation setups, which either use combinations of explicit-state model checking and predicate abstraction, or bounded model checking and symbolic execution. A comparison with state-of-the-art test-generation tools reveals that CoVeriTest achieves higher coverage for many programs (about 15%).

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60.
Characterizing the crack stability to predict the behaviour of ceramics designed for industrial use is a challenging issue. It requires accurate crack tip detection during the controlled crack propagation of notched bending tests. Different indirect methods are available, like for instance the compliance technique. Recently, techniques based on digital image correlation (DIC) have emerged: finite-element DIC (FE-DIC) with a finite element decomposition of the displacement field, integrated-DIC (I-DIC) based on Williams?? series decomposition of the displacement field and regularized-DIC (R-DIC) for mechanical constraints. These full-field techniques enable the quantification of the crack length and the stress intensity factor K I . In this paper, these four methods are compared in terms of measurements of crack lengths and stress intensity factors during a notched bending test. The tested material is a damageable quasi-brittle ceramic at room temperature. The non linearity of the stress-strain law of this microcraked ceramic results in a complex behaviour that is not captured by the compliance method during the bending test. Therefore the linear elastic compliance method leads to a different estimation of crack lengths and stress intensity factors compared to DIC methods. On the other hand, the R-DIC approach handles the non linear material constitutive behaviour. It allows a deeper analysis of the mechanical fields, the energy dissipation and the damage mechanisms during the crack propagation.  相似文献   
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