Investigation of magnetic and ferroelectric properties along with the magnetoelectric coupling behavior for asserting a room temperature bi-phase composite as multiferroics

Various composites of nominal composition (1-x)Ba_0.95Ca_0.05TiO₃?+?xLi_0.1Cu_0.1Co_0.1Zn_0.6Fe_2.1O₄ have been prepared and studied thoroughly. X-ray diffraction and Rietveld refinement confirmed the presence of Ba_0.95Ca_0.05TiO₃ and Li_0.1Cu_0.1Co_0.1Zn_0.6Fe_2.1O₄ phases in the composites. The microstructures have been investigated by field emission scanning electron microscopy. Temperature dependent dielectric constant shows two peaks, one is at 150 °C and another at 270 °C for x?=?0.10 composite which resembles the characteristic ferroelectric and ferromagnetic transition peaks. A gradual progression of ferro-para electric transition towards room temperature is observed with doping. The non-Debye type dipole relaxations have been found. The linearity in the log(σ_AC) vs. log(ω) plots indicate that conduction is due to small polaron hopping. The real part of initial permeability increases with growing ferrite concentration but the cut-off frequency decreases. The magnetic property is also enhanced with doping content. The typical ferroelectric hysteresis loops have also seen with the addition of Li_0.1Cu_0.1Co_0.1Zn_0.6Fe_2.1O₄ up to x?=?0.40. The impedance values are found to decreases in the Nyquist plots. The magnetoelectric voltage coefficient is obtained 287?×?10³ V/mT for x?=?0.15 at room temprrature. We found both ferromagnetic and ferroelectric hysteresis loops at room temperature. So, it confirms that the composites exhibit room temperature multiferroicity. This type of composites offers variety of opportunity for multifunctional devices application like hetero-structured read / write memory devices, switching devices and magnetic field sensing devices.

     

Angiogenesis and Anti-Angiogenic Treatment in Prostate Cancer: Mechanisms of Action and Molecular Targets

Prostate cancer (PC) is the most common cancer in men and the second leading cause of cancer-related death worldwide. Many therapeutic advances over the last two decades have led to an improvement in the survival of patients with metastatic PC, yet the majority of these patients still succumb to their disease. Antiagiogenic therapies have shown substantial benefits for many types of cancer but only a marginal benefit for PC. Ongoing clinical trials investigate antiangiogenic monotherapies or combination therapies. Despite the important role of angiogenesis in PC, clinical trials in refractory castration-resistant PC (CRPC) have demonstrated increased toxicity with no clinical benefit. A better understanding of the mechanism of angiogenesis may help to understand the failure of trials, possibly leading to the development of new targeted anti-angiogenic therapies in PC. These could include the identification of specific subsets of patients who might benefit from these therapeutic strategies. This paper provides a comprehensive review of the pathways involved in the angiogenesis, the chemotherapeutic agents with antiangiogenic activity, the available studies on anti-angiogenic agents and the potential mechanisms of resistance.     

Comparison of surface functional groups and metal uptake efficiency of rice husk harvested from different climatic zones

Rice husk (RH) is a very effective natural adsorbent for fast removal of heavy metal cations from water solutions. Application of RH for removal of some heavy metal ions, such as Ni, Zn, Mn, Co, Cu, Pb and Cd from water solutions has been studied and different maximum adsorption capacities and a variety of optimized conditions were reported in the literature. In this work, the efficiency of RH harvested from different climatic regions was studied. For this proposal, different RH samples were collected from three different climatic regions of Iran (nominated as RH1 to RH3); their removal efficiencies of heavy metal cations of Ni(2+), Cu(2+) and Cd(2+) were investigated and compared. The adsorption data at optimum conditions could be assessed well by both Langmuir and Freundlich models. Statistical analysis of the results of adsorption isotherms showed that different RH samples have different efficiencies in uptake of these heavy metal ions. The RH samples were characterized using Fourier transform infrared spectroscopy and Boehm titration, which indicated that amounts of functional groups differed between RHs that are grown in different climatic conditions.     

High-Temperature Thermoelectric Properties of Compounds in the System Zn x In y O x+1.5y

Based on results obtained utilizing combinatorial chemistry techniques to screen the thermoelectric power factor of materials in the system Zn _x In _y O _x+1.5y , several multiphase candidates were down-selected and investigated in terms of their thermoelectric response from room temperature to 1050°C. While the screening experiments suggested that peaks in the power factor occur at relatively high indium oxide content, only the thermoelectric properties of zinc-oxide-rich homologous layered phases in the system (In₂O₃)(ZnO) _k have been well documented, since the phases where k < 3 cannot be easily formed. In the present study, indium-oxide-rich materials in the system In₂O₃–(In₂O₃)(ZnO)₃ were fabricated and their figures of merit were determined. The results suggest that the indium-oxide-rich phases have improved figures of merit, especially at elevated temperatures, relative to the best performing k phases by combining the high power factor of In₂O₃ and the low thermal conductivity of (In₂O₃)(ZnO) _k .     

Yield effects of rust-resistant wheat varieties in Ethiopia

Breeding crops for disease resistance is a sustainable approach to reduce yield losses. While significant research on the adoption and impacts of improved crop varieties exists, most studies have analyzed yield effects in general without distinguishing between different varietal traits and characteristics. Here, panel data from wheat farmers in Ethiopia were used to compare improved varieties that are resistant to stripe rust (caused by Puccinia striiformis f. sp. tritici) with improved susceptible and traditional susceptible varieties. Production function estimates suggest that improved resistant varieties raise effective yields by 8% in comparison to local susceptible varieties. The yield difference between improved resistant and improved susceptible varieties is positive but small because rust levels were not very high in the years under study. However, under drought and other abiotic stresses, improved varieties – with and without resistance to stripe rust – performed notably worse than local varieties. The worse performance under abiotic stress may explain why many farmers have recently switched back to growing traditional varieties. Sustainable adoption needs a combination of various traits in the same varieties, including high yield potential, grain quality, disease resistance and tolerance to drought and other production stresses.     

Genealogy of the 129 inbred strains: 129/SvJ is a contaminated inbred strain

The 129 mouse is the most widely used strain in gene targeting experiments. However, numerous substrains exist with demonstrable physiological differences. In this study a set of simple sequence length polymorphisms (SSLPs) was used to determine the relatedness of selected 129 substrains. 129/SvJ was significantly different from the other 129 substrains and is more accurately classified as a recombinant congenic strain (129cX/Sv), being derived from 129/Sv and an unknown strain. This mixed genetic background could complicate gene targeting experiments by reducing homologous recombination efficiency when constructs and ES cells are not derived from the same 129 substrain. Additionally, discrepancies due to different genetic backgrounds may arise when comparing phenotypes of genes targeted in different 129-derived ES cell lines.